Research progress on the role of adipose-derived stem cell exosomes in skin scar formation

Wang Liuxin; Li Yunpeng; Wu Simo; Zhang Junrui; Kong Liang; Lu Bin; Liu Fuwei; Li Zhiye

doi:10.3760/cma.j.cn501225-20220308-00057

Volume 39 Issue 3

Mar. 2023

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2023 > 39(3): 295-300

Wang LX,Li YP,Wu SM,et al.Research progress on the role of adipose-derived stem cell exosomes in skin scar formation[J].Chin J Burns Wounds,2023,39(3):295-300.DOI: 10.3760/cma.j.cn501225-20220308-00057.

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Research progress on the role of adipose-derived stem cell exosomes in skin scar formation

doi: 10.3760/cma.j.cn501225-20220308-00057

1.
Basic Medical Science Academy of Air Force Medical University, Xi'an 710032, China
2.
Department of Oral and Maxillofacial Surgery, the Third Affiliated Hospital of Air Force Medical University, State Key Laboratory of Military StomatologyNational Clinical Research Center for Oral DiseasesShaanxi Clinical Research Center for Oral Diseases, Xi'an 710032, China

Funds:

Youth Science Foundation Project of National Natural Science Foundation of China 81801969

General Program of National Natural Science Foundation of China 81970988

Independent Research Project (Class A) of State Key Laboratory of Military Stomatology in 2019 2019ZA08

More Information

Corresponding author: Li Zhiye, Email: verylzy@163.com
Received Date: 2022-03-08
Available Online: 2023-03-23

Abstract

Abstract

The adipose-derived stem cell exosomes are subcellular structures of adipose stem cells. They are nano-sized membrane vesicles that can transport various cell components and act on target cells by paracrine, and they play an important role in the exchanges of substance and information between cells. Scar healing is the commonest way of healing after skin tissue injury. Pathological scar can not only cause movement dysfunction, but also lead to deformity, which affects the appearance of patients and brings life and mental pressure to the patients. In recent years, many researches have shown that the adipose-derived stem cell exosomes contain a variety of bioactive molecules, which play an important role in reducing scar formation and scar-free wound healing, by affecting the proliferation and migration of fibroblasts and the composition of extracellular matrix. This article reviewed the recent literature on the roles and mechanisms of adipose-derived stem cell exosomes in scar formation, and prospected the future application and development of adipose-derived stem cell exosomes in scar treatment.
- Exosomes,
- Cicatrix,
- Fibroblasts,
- Extracellular matrix,
- Adipose-derived stem cells

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References

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