Research advances on application of pancreatic stone protein in the early diagnosis of sepsis

He Ting; Liu Wei; Shen Chuan'an

doi:10.3760/cma.j.cn501225-20221120-00498

Volume 39 Issue 10

Oct. 2023

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2023 > 39(10): 985-988

He T,Liu W,Shen CA.Research advances on application of pancreatic stone protein in the early diagnosis of sepsis[J].Chin J Burns Wounds,2023,39(10):985-988.DOI: 10.3760/cma.j.cn501225-20221120-00498.

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He T,Liu W,Shen CA.Research advances on application of pancreatic stone protein in the early diagnosis of sepsis[J].Chin J Burns Wounds,2023,39(10):985-988.DOI: 10.3760/cma.j.cn501225-20221120-00498.

Citation:

He T,Liu W,Shen CA.Research advances on application of pancreatic stone protein in the early diagnosis of sepsis[J].Chin J Burns Wounds,2023,39(10):985-988.DOI: 10.3760/cma.j.cn501225-20221120-00498.

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Research advances on application of pancreatic stone protein in the early diagnosis of sepsis

doi: 10.3760/cma.j.cn501225-20221120-00498

Department of Burns and Plastic Surgery, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China

Funds:

General Program of National Natural Science Foundation of China 82072169, 82272279

Military Logistics Scientific Research Project Health Special Project 22BJZ35

Major Program of Military Logistics Research Plan ALB18J001

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Corresponding author: Shen Chuan'an, Email: shenchuanan@126.com
Received Date: 2022-11-20
Available Online: 2023-10-26

Abstract

Abstract

Sepsis is a severe life-threatening syndrome characterized by an abnormal host response to infection that can rapidly evolve into septic shock and multiple organ failure. Treatment of sepsis depends on early identification and diagnosis as well as adequate and timely anti-infection and multi-organ functional support. In recent years, pancreatic stone protein has been widely studied as a new biomarker for sepsis. Existing evidence shows that compared with the commonly used inflammatory markers in clinical practice, pancreatic stone protein has higher sensitivity and specificity in the diagnosis of sepsis. It enables the early diagnosis of sepsis and assessment of the severity of septic patients to a certain extent. This article reviews the characteristics, biological functions, diagnostic features, and clinical application of pancreatic stone protein.
- Sepsis,
- Lithostathine,
- Infection,
- Diagnosis

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References(37)

References

[1]	姚咏明,张卉.改善脓毒症患者长期预后的康复治疗对策[J].中华烧伤与创面修复杂志,2022,38(3):201-206.DOI: 10.3760/cma.j.cn501120-20211004-00344.
[2]	曾茁,彭毅志,袁志强.脓毒症生物标志物的研究进展[J].中华烧伤与创面修复杂志,2023,39(7):679-684.DOI: 10.3760/cma.j.cn501225-20230320-00086.
[3]	FidalgoP, NoraD, CoelhoL, et al. Pancreatic stone protein: review of a new biomarker in sepsis[J]. J Clin Med, 2022, 11(4): 1085. DOI: 10.3390/jcm11041085.
[4]	GrafR.Pancreatic stone protein - sepsis and the riddles of the exocrine pancreas[J].Pancreatology,2020,20(3):301-304.DOI: 10.1016/j.pan.2020.01.016.
[5]	SchlapbachLJ,GiannoniE,WellmannS,et al.Normal values for pancreatic stone protein in different age groups[J].BMC Anesthesiol,2015,15:168.DOI: 10.1186/s12871-015-0149-y.
[6]	KeelM,HärterL,RedingT,et al.Pancreatic stone protein is highly increased during posttraumatic sepsis and activates neutrophil granulocytes[J].Crit Care Med,2009,37(5):1642-1648.DOI: 10.1097/CCM.0b013e31819da7d6.
[7]	StoneS,AbreuD,MahadevanJ,et al.Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells[J].Sci Rep,2019,9(1):5199.DOI: 10.1038/s41598-019-41604-4.
[8]	LiL,BimmlerD,GrafR,et al.PSP/reg inhibits cultured pancreatic stellate cell and regulates MMP/ TIMP ratio[J].Eur J Clin Invest,2011,41(2):151-158.DOI: 10.1111/j.1365-2362.2010.02390.x.
[9]	JinCX,HayakawaT,KoSB,et al.Pancreatic stone protein/regenerating protein family in pancreatic and gastrointestinal diseases[J].Intern Med,2011,50(15):1507-1516.DOI: 10.2169/internalmedicine.50.5362.
[10]	PathakA,AgrawalA. Evolution of C-reactive protein[J].Front Immunol,2019,10:943.DOI: 10.3389/fimmu.2019.00943.
[11]	姚咏明,张卉,童亚林.深化对烧伤脓毒症诊断体系与治疗策略的认识[J].中华烧伤杂志,2021,37(5):404-409.DOI: 10.3760/cma.j.cn501120-20200703-00337.
[12]	WuQ, NieJ, WuFX, et al. Prognostic value of high-sensitivity C-reactive protein, procalcitonin and pancreatic stone protein in pediatric sepsis[J]. Med Sci Monit, 2017, 23: 1533-1539. DOI: 10.12659/msm.900856.
[13]	HamadeB,HuangDT.Procalcitonin: where are we now?[J].Crit Care Clin,2020,36(1):23-40.DOI: 10.1016/j.ccc.2019.08.003.
[14]	Mierzchała-PasierbM,Lipińska-GedigaM.Sepsis diagnosis and monitoring - procalcitonin as standard, but what next?[J].Anaesthesiol Intensive Ther,2019,51(4):299-305.DOI: 10.5114/ait.2019.88104.
[15]	HuPY,ChenYM,PangJL,et al.Association between IL-6 polymorphisms and sepsis[J].Innate Immun,2019,25(8):465-472.DOI: 10.1177/1753425919872818.
[16]	ZengGB,ChenD,ZhouRX,et al.Combination of C-reactive protein, procalcitonin, IL-6, IL-8, and IL-10 for early diagnosis of hyperinflammatory state and organ dysfunction in pediatric sepsis[J].J Clin Lab Anal,2022,36(7):e24505.DOI: 10.1002/jcla.24505.
[17]	XiangZY,ChenXD,ZhouXM,et al.Development and application of a novel aldehyde nanoparticle-based amplified luminescent proximity homogeneous assay for rapid quantitation of pancreatic stone protein[J].Clin Chim Acta,2022,535:120-130. DOI: 10.1016/j.cca.2022.08.020.
[18]	PuginJ,DaixT,PaganiJL,et al.Serial measurement of pancreatic stone protein for the early detection of sepsis in intensive care unit patients: a prospective multicentric study[J].Crit Care,2021,25(1):151.DOI: 10.1186/s13054-021-03576-8.
[19]	KleinHJ, NiggemannP, BuehlerPK, et al. Pancreatic stone protein predicts sepsis in severely burned patients irrespective of trauma severity: a monocentric observational study[J]. Ann Surg, 2021, 274(6): e1179-e1186. DOI: 10.1097/SLA.0000000000003784.
[20]	EggimannP,QueYA,RebeaudF.Measurement of pancreatic stone protein in the identification and management of sepsis[J].Biomark Med,2019,13(2):135-145.DOI: 10.2217/bmm-2018-0194.
[21]	TatemichiN,TakahashiC,HayakawaS,et al.Enzyme immunoassay and characterization of pancreatic stone proteins in human urine[J].J Clin Lab Anal,1993,7(6):365-370.DOI: 10.1002/jcla.1860070611.
[22]	GrafR,SchiesserM,LüssiA,et al.Coordinate regulation of secretory stress proteins (PSP/reg, PAP Ⅰ, PAP Ⅱ, and PAP Ⅲ) in the rat exocrine pancreas during experimental acute pancreatitis[J].J Surg Res,2002,105(2):136-144.DOI: 10.1006/jsre.2002.6387.
[23]	PalmiereC,AugsburgerM.Pancreatic stone protein as a postmortem biochemical marker for the diagnosis of sepsis[J].Leg Med (Tokyo),2015,17(1):9-13.DOI: 10.1016/j.legalmed.2014.08.003.
[24]	QueYA,DelodderF,GuessousI,et al.Pancreatic stone protein as an early biomarker predicting mortality in a prospective cohort of patients with sepsis requiring ICU management[J].Crit Care,2012,16(4):R114.DOI: 10.1186/cc11406.
[25]	RassAA, TalatMA, ArafaMA, et al. The role of pancreatic stone protein in diagnosis of early onset neonatal sepsis[J]. Biomed Res Int, 2016, 2016: 1035856. DOI: 10.1155/2016/1035856.
[26]	LagadinouM,ParaskevasT,VelissarisD,et al.The role of pancreatic stone protein as a prognostic factor for COVID-19 patients[J].Eur Rev Med Pharmacol Sci,2022,26(17):6391-6395.DOI: 10.26355/eurrev_202209_29666.
[27]	NiggemannP, RittirschD, BuehlerPK, et al. Incidence and time point of sepsis detection as related to different sepsis definitions in severely burned patients and their accompanying time course of pro-inflammatory biomarkers[J]. J Pers Med, 2021, 11(8): 701. DOI: 10.3390/jpm11080701.
[28]	KleinHJ,CsordasA,FalkV,et al.Pancreatic stone protein predicts postoperative infection in cardiac surgery patients irrespective of cardiopulmonary bypass or surgical technique[J].PLoS One,2015,10(3):e0120276.DOI: 10.1371/journal.pone.0120276.
[29]	GukasjanR,RaptisDA,SchulzHU,et al.Pancreatic stone protein predicts outcome in patients with peritonitis in the ICU[J].Crit Care Med,2013,41(4):1027-1036.DOI: 10.1097/CCM.0b013e3182771193.
[30]	黄云峰,周帆,徐晓林.胰石蛋白在呼吸机相关性肺炎患者支气管肺泡灌洗液及呼出气冷凝液中的表达及检测价值[J].实用临床医药杂志,2019,23(11):99-102.DOI: 10.7619/jcmp.201911028.
[31]	KleinHJ, BuehlerPK, NiggemannP, et al. Expression of pancreatic stone protein is unaffected by trauma and subsequent surgery in burn patients[J]. World J Surg, 2020, 44(9): 3000-3009. DOI: 10.1007/s00268-020-05589-w.
[32]	KleinHJ, RittirschD, BuehlerPK, et al. Response of routine inflammatory biomarkers and novel Pancreatic Stone Protein to inhalation injury and its interference with sepsis detection in severely burned patients[J].Burns,2021,47(2):338-348.DOI: 10.1016/j.burns.2020.04.039.
[33]	PrazakJ,IrincheevaI,LlewelynMJ,et al.Accuracy of pancreatic stone protein for the diagnosis of infection in hospitalized adults: a systematic review and individual patient level meta-analysis[J].Crit Care,2021,25(1):182.DOI: 10.1186/s13054-021-03609-2.
[34]	QueYA, GuessousI, Dupuis-LozeronE, et al. Prognostication of mortality in critically ill patients with severe infections[J]. Chest, 2015, 148(3): 674-682. DOI: 10.1378/chest.15-0123.
[35]	杨玉丹,于玉兰,王维展.急性百草枯中毒患者血清肌腱蛋白C、胰石蛋白、动脉血乳酸水平与中毒严重指数的关系[J].中国工业医学杂志,2021,34(4):306-309.DOI: 10.13631/j.cnki.zggyyx.2021.04.005.
[36]	SamuelL. Point-of-care testing in microbiology[J]. Clin Lab Med, 2020, 40(4): 483-494. DOI: 10.1016/j.cll.2020.08.006.
[37]	ChenH,LiuKK,LiZ,et al. Point of care testing for infectious diseases[J].Clin Chim Acta,2019,493:138-147.DOI: 10.1016/j.cca.2019.03.008.

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Research advances on application of pancreatic stone protein in the early diagnosis of sepsis

doi: 10.3760/cma.j.cn501225-20221120-00498

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Research advances on application of pancreatic stone protein in the early diagnosis of sepsis

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