Novel strategy of sepsis immunomodulation targeting dendritic cells

Yao Yongming; Zhang Hui; Wu Yao

doi:10.3760/cma.j.cn501225-20230321-00087

Volume 39 Issue 7

Jul. 2023

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2023 > 39(7): 606-611

Yao YM,Zhang H,Wu Y.Novel strategy of sepsis immunomodulation targeting dendritic cells[J].Chin J Burns Wounds,2023,39(7):606-611.DOI: 10.3760/cma.j.cn501225-20230321-00087.

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Yao YM,Zhang H,Wu Y.Novel strategy of sepsis immunomodulation targeting dendritic cells[J].Chin J Burns Wounds,2023,39(7):606-611.DOI: 10.3760/cma.j.cn501225-20230321-00087.

Citation:

Yao YM,Zhang H,Wu Y.Novel strategy of sepsis immunomodulation targeting dendritic cells[J].Chin J Burns Wounds,2023,39(7):606-611.DOI: 10.3760/cma.j.cn501225-20230321-00087.

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Novel strategy of sepsis immunomodulation targeting dendritic cells

doi: 10.3760/cma.j.cn501225-20230321-00087

Translational Medicine Research Center, Medical Innovation Research Division and the Fourth Medical Center of PLA General Hospital, Beijing 100853, China

Funds:

National Key Research and Development Program of China 2022YFA1104604

Key Program of National Natural Science Foundation of China 82130062, 82241062

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Corresponding author: Yao Yongming, Email: c_ff@sina.com
Received Date: 2023-03-21

Abstract

Abstract

Dendritic cells (DCs) are the major antigen-presenting cells that play critical roles in regulating both innate and acquire immune responses. In the state of sepsis, the number of DCs is obviously decreased with inhibited antigen presenting ability as well as abnormal cytokine secretion, thereby resulting in an impairment of T lymphocyte activation. Previous studies have demonstrated that the depletion and dysfunction of DCs appear to be the main causes associated with the development of sepsis-induced immunosuppression. Based on the characteristic changes of DCs in sepsis and analysis of recent research progress, the authors propose a novel strategy of immunomodulation targeting the apoptosis, differentiation, and dysfunction of DCs, in order to provide new ideas for the prevention and treatment of severe burns and trauma complicated with sepsis.
- Sepsis,
- Immunity, cellular,
- Dendritic cells,
- Immune response,
- Immunomodulation,
- Interference strategy

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References

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Novel strategy of sepsis immunomodulation targeting dendritic cells

doi: 10.3760/cma.j.cn501225-20230321-00087

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Novel strategy of sepsis immunomodulation targeting dendritic cells

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