Diagnostic value of thromboelastography combined with conventional coagulation test for trauma-induced coagulopathy in patients with electric burns in the early stage

Li Quan; Ba Te; Cao Shengjun; Li Fang; Yan Zengqiang; Hou Zhihui; Wang Lingfeng

doi:10.3760/cma.j.cn501225-20240416-00135

Volume 40 Issue 8

Aug. 2024

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2024 > 40(8): 740-745

Wei ZR,Zhang YJ,Wang DL.Roles of hypoxia and inflammation in wound healing[J].Chin J Burns Wounds,2024,40(6):507-513.DOI: 10.3760/cma.j.cn501225-20240111-00014.

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Li Q,Ba T,Cao SJ,et al.Diagnostic value of thromboelastography combined with conventional coagulation test for trauma-induced coagulopathy in patients with electric burns in the early stage[J].Chin J Burns Wounds,2024,40(8):740-745.DOI: 10.3760/cma.j.cn501225-20240416-00135.

Wei ZR,Zhang YJ,Wang DL.Roles of hypoxia and inflammation in wound healing[J].Chin J Burns Wounds,2024,40(6):507-513.DOI: 10.3760/cma.j.cn501225-20240111-00014.

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Diagnostic value of thromboelastography combined with conventional coagulation test for trauma-induced coagulopathy in patients with electric burns in the early stage

doi: 10.3760/cma.j.cn501225-20240416-00135

Department of Burn Surgery, the Third Affiliated Hospital of Inner Mongolia Medical University, Burn Medical Institute of Inner Mongolia, Baotou 014010, China

Funds:

Science and Technology Program of the Joint Fund of Scientific Research for the Public Hospitals of Health Commission of Inner Mongolia Autonomous Region 2023GLLH0245

Inner Mongolia Natural Science Foundation 2021MS08066

Inner Mongolia Medical University Joint Project YKD2024LH015

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Corresponding author: Wang Lingfeng, Email: wlf7413@vip.sina.com
Received Date: 2024-04-16

Abstract

Abstract

Objective To explore the diagnostic value of thromboelastography (TEG) combined with conventional coagulation test (CCT) for trauma-induced coagulopathy (TIC) in patients with electric burns in the early stage. Methods This study was a retrospective case series research. From February 2018 to February 2024, the clinical data of 128 electric burn patients and 118 thermal burn patients who met the inclusion criteria and admitted to the Department of Burn Surgery of the Third Affiliated Hospital of Inner Mongolia Medical University were collected, including 224 males and 22 females, aged (38±14) years. The patients were divided into electric burn group (128 cases) and thermal burn group (118 cases) according to their injuries. The incidence of TIC, the indicators of CCT, including prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen level, D-dimer level, platelet count, and the detection indicators of TEG, including coagulation reaction time, K value, coagulation angle, maximum thrombus amplitude, comprehensive coagulation index, and lysis rate at 30 minutes after maximum amplitude within 8 hours of admission were compared between the two groups of patients. The Kappa test was used to analyze the consistency between CCT and TEG in diagnosing TIC in patients with electric burns in the early stage after burns. The receiver operating characteristic curves of CCT, TEG, and TEG combined with CCT in diagnosing TIC in 128 patients with electric burns were drawn, and the area under the curve (AUC), the maximum Jordan index, and sensitivity and specificity at this time were calculated. Results The proportion of patients diagnosed with TIC in electric burn group was 19.5% (25/128) within 8 hours of admission, which was significantly higher than 10.2% (12/118) in thermal burn group (χ²=4.21, P<0.05). Compared with those in thermal burn group, prothrombin time was significantly shortened (t=-2.32, P<0.05), D-dimer level, fibrinogen level, and platelet count were significantly increased (with Z values of -2.11 and -4.16, respectively, t=4.69, P<0.05), the coagulation reaction time was significantly shortened (t=-2.51, P<0.05), and the maximum thrombus amplitude and lysis rate at 30 minutes after the maximum amplitude were significantly increased (with t values of 2.50 and 2.10, respectively, P<0.05) in patients in electric burn group within 8 hours of admission. There were no statistically significant differences in the other CCT indicators and TEG detection indicators between the two groups of patients (P>0.05). The CCT and TEG showed high consistency in the diagnosis of TIC in patients with electric burns in the early stage after burns (Kappa=0.63, P<0.05). The AUCs of TEG combined with CCT, TEG, and CCT in diagnosis of TIC in 128 patients with electric burns were 0.92, 0.84, and 0.77 (with 95% confidence intervals of 0.86-0.97, 0.71-0.97, and 0.71-0.97, respectively), with the maximum Jordan indexes of 0.86, 0.57, and 0.65. At this time, the specificity was 93.7%, 83.2%, and 88.2%, respectively, and the sensitivity was 92.3%, 87.5%, and 76.5%, respectively. Conclusions Patients with electric burns are in a state of hypercoagulability of coagulation system and hyperfunction of fibrinolysis system in the early stage after burns, and TEG combined with CCT can increase the diagnostic rate of TIC in patients with electric burns.
- Burns, electric,
- Thromboelastography,
- Conventional coagulation test,
- Trauma-induced coagulopathy

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Diagnostic value of thromboelastography combined with conventional coagulation test for trauma-induced coagulopathy in patients with electric burns in the early stage

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Diagnostic value of thromboelastography combined with conventional coagulation test for trauma-induced coagulopathy in patients with electric burns in the early stage

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