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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  >  > Accepted Manuscript
Wu Jie,Zhang Huimin,Liu Rui,et al.Meta-analysis of the effects of pulsed dye laser combined with fractional carbon dioxide laser in the treatment of hypertrophic scars in children[J].Chin J Burns Wounds,2026,42(7):1-8.DOI: 10.3760/cma.j.cn501225-20241224-00502.
Citation: Wu Jie,Zhang Huimin,Liu Rui,et al.Meta-analysis of the effects of pulsed dye laser combined with fractional carbon dioxide laser in the treatment of hypertrophic scars in children[J].Chin J Burns Wounds,2026,42(7):1-8.DOI: 10.3760/cma.j.cn501225-20241224-00502.
shu

Meta-analysis of the effects of pulsed dye laser combined with fractional carbon dioxide laser in the treatment of hypertrophic scars in children

doi: 10.3760/cma.j.cn501225-20241224-00502
  • 1.

    Department of Burn and Wound Repair Surgery, Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China

  • 2.

    School of Clinical Medicine, Shandong Second Medical University, Weifang 261053, China

Funds:

National Administration of Traditional Chinese Medicine Co-constructed Science and Technology Project GZY-KJS-SD-2023-071

Natural Science Foundation of Shandong Province ZR2024MH021

Shandong Traditional Chinese Medicine Science and Technology General Program M-2023037

More Information
  • Corresponding author: Cui Rongtao, Email: cuirt1986@outlook.com
  • Received Date: 2024-12-24
    Available Online: 2026-07-03
    Abstract
  •   Objective  To evaluate the efficacy of pulsed dye laser (PDL) combined with fractional carbon dioxide laser for the treatment of hypertrophic scars (HSs) in children.  Methods  This study was a meta-analysis study. Databases including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, and VIP Chinese Journal Service Platform were retrieved to obtain the publicly published retrospective and prospective studies on the efficacy of PDL combined with fractional carbon dioxide laser for pediatric HS from the establishment of each database to October 31, 2024. The outcome indexes included the total score of the patient and observer scar assessment scale (POSAS) and laser treatment-related adverse reactions. Stata version 16.0 software was used to conduct a meta-analysis.  Results  A total of 7 studies were included, involving 348 children with HSs, of whom at least 296 had burn-induced HSs. Meta-analysis result showed that PDL combined with fractional carbon dioxide laser significantly reduced the total POSAS score in pediatric HS (with standardized mean difference of -7.76, 95% CI of -10.91 to-4.61, P<0.05). Subgroup analysis results suggested that geographic distribution, scar duration, intervention measures, and fractional carbon dioxide laser energy parameters might be sources of heterogeneity for the total POSAS score. The incidence of adverse reactions of PDL combined with fractional carbon dioxide laser for pediatric HS was low, at 0.04 (with 95% CI of 0.02-0.06, P<0.05). There was no publication bias in total POSAS score or its subgroup analyses (including geographic distribution, scar duration, intervention measures, fractional laser parameters, and assessor) or adverse reactions (P<0.05).  Conclusions  PDL combined with fractional carbon dioxide laser is beneficial for the recovery of pediatric HS, with a low rate of adverse reactions and a favorable safety profile. For pediatric HS, the early intervention window within 3 months after scar formation should be prioritized, and a regimen combining low-energy (≤50 mJ) fractional carbon dioxide laser flexibly with PDL may yield better therapeutic outcomes.

     

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