| Citation: | Hu DH,Li MY,Wang P.Frontier progress in complex wound repair: from microenvironment regulation to precision medical practice[J].Chin J Burns Wounds,2025,41(5):417-425.DOI: 10.3760/cma.j.cn501225-20250407-00171. |
| [1] |
ArmstrongDG,TanTW,BoultonAJM,et al.Diabetic foot ulcers: a review[J].JAMA,2023,330(1):62-75.DOI: 10.1001/jama.2023.10578.
|
| [2] |
TriccoAC,AntonyJ,VafaeiA,et al.Seeking effective interventions to treat complex wounds: an overview of systematic reviews[J].BMC Med,2015,13:89.DOI: 10.1186/s12916-015-0288-5.
|
| [3] |
KantorJ,MargolisDJ.A multicentre study of percentage change in venous leg ulcer area as a prognostic index of healing at 24 weeks[J].Br J Dermatol,2000,142(5):960-964.DOI: 10.1046/j.1365-2133.2000.03478.x.
|
| [4] |
姚泽欣,付小兵,程飚.慢性创面愈合新理念:姑息性创面治疗的研究进展[J].中华烧伤杂志,2020,36(8):754-757.DOI: 10.3760/cma.j.cn501120-20190929-00388.
|
| [5] |
JiangY,HuangS,FuX,et al.Epidemiology of chronic cutaneous wounds in China[J].Wound Repair Regen,2011,19(2):181-188.DOI: 10.1111/j.1524-475X.2010.00666.x.
|
| [6] |
潘选良,韩春茂.《优化技术在下肢慢性创面愈合中的应用共识》简介[J].中华烧伤杂志,2017,33(9):589-591.DOI: 10.3760/cma.j.issn.1009-2587.2017.09.017.
|
| [7] |
ZhangY,AlexanderPB,WangXF.TGF-β family signaling in the control of cell proliferation and survival[J].Cold Spring Harb Perspect Biol,2017,9(4):a022145.DOI: 10.1101/cshperspect.a022145.
|
| [8] |
ZhaoR,LiangH,ClarkeE,et al.Inflammation in chronic wounds[J].Int J Mol Sci,2016,17(12):2085.DOI: 10.3390/ijms17122085.
|
| [9] |
Di MiccoR,KrizhanovskyV,BakerD,et al.Cellular senescence in ageing: from mechanisms to therapeutic opportunities[J].Nat Rev Mol Cell Biol,2021,22(2):75-95.DOI: 10.1038/s41580-020-00314-w.
|
| [10] |
Al MamunA,ShaoC,GengP,et al.Recent advances in the role of neuroregulation in skin wound healing[J/OL].Burns Trauma,2025,13:tkae072[2025-04-07].https://pubmed.ncbi.nlm.nih.gov/39872039/.DOI: 10.1093/burnst/tkae072.
|
| [11] |
韩飞, 张万福, 佟琳, 等. 阔筋膜-股前外侧皮瓣复合移植修复颌面部根治性肿瘤切除术后复杂缺损的临床效果[J]. 中华烧伤与创面修复杂志, 2025, 41(5):440-446. DOI: 10.3760/cma.j.cn501225-20240801-00290.
|
| [12] |
ChenW,HazoorS,MadiganR,et al.Alkaline-responsive polydiacetylene-peptide hydrogel for pH-sensing and on-demand antimicrobial release[J].Mater Today Adv,2022,16: 100288.DOI: 10.1016/j.mtadv.2022.100288.
|
| [13] |
AminM,LammersT,Ten HagenTLM.Temperature-sensitive polymers to promote heat-triggered drug release from liposomes: towards bypassing EPR[J].Adv Drug Deliv Rev,2022,189:114503.DOI: 10.1016/j.addr.2022.114503.
|
| [14] |
Raeeszadeh-SarmazdehM, DoLD, HritzBG.Metalloproteinases and their inhibitors: potential for the development of new therapeutics[J].Cells,2020,9(5):1313.DOI: 10.3390/cells9051313.
|
| [15] |
LigorioC,MataA.Synthetic extracellular matrices with function-encoding peptides[J]. Nat Rev Bioeng,2023,1(7): 518-536.DOI: 10.1038/s44222-023-00055-3.
|
| [16] |
MishraA,ModiU,SharmaR,et al.Biochemical and biophysical cues of the extracellular matrix modulates stem cell fate: progress and prospect in extracellular matrix mimicking biomaterials[J]. Biomed Eng Adv,2025,9:100143. DOI: 10.1016/j.bea.2024.100143.
|
| [17] |
WuF,RenY,LvW,et al.Generating dual structurally and functionally skin-mimicking hydrogels by crosslinking cell-membrane compartments[J].Nat Commun,2024,15(1):802.DOI: 10.1038/s41467-024-45006-7.
|
| [18] |
HamaR,ReinhardtJW,UlziibayarA,et al.Recent tissue engineering approaches to mimicking the extracellular matrix structure for skin regeneration[J].Biomimetics (Basel),2023,8(1):130.DOI: 10.3390/biomimetics8010130.
|
| [19] |
TavafoghiM,DarabiMA,MahmoodiM,et al.Multimaterial bioprinting and combination of processing techniques towards the fabrication of biomimetic tissues and organs[J]. Biofabrication,2021,13(4):042002. DOI: 10.1088/1758-5090/ac0b9a.
|
| [20] |
KhoeiniR,NosratiH,AkbarzadehA,et al.Natural and synthetic bioinks for 3D bioprinting[J].Adv NanoBiomed Res,2021,1(8):2000097.DOI: 10.1002/anbr.202000097.
|
| [21] |
LiangX,DingY,ZhangY,et al.Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives[J].Cell Transplant,2014,23(9):1045-1059.DOI: 10.3727/096368913X667709.
|
| [22] |
HoseiniSM,MontazeriF.Cell origin and microenvironment: the players of differentiation capacity in human mesenchymal stem cells[J].Tissue Cell,2025,93:102709.DOI: 10.1016/j.tice.2024.102709.
|
| [23] |
GuoL,XiaoD,XingH,et al.Engineered exosomes as a prospective therapy for diabetic foot ulcers[J/OL].Burns Trauma,2024,12:tkae023[2025-04-07].https://academic.oup.com/burnstrauma/article/doi/ 10.1093/burnst/tkae023/7715755.DOI: 10.1093/burnst/tkae023.
|
| [24] |
YuanX,LiL,LiuH,et al.Strategies for improving adipose-derived stem cells for tissue regeneration[J/OL].Burns Trauma,2022,10:tkac028[2025-04-07].https://academic.oup.com/burnstrauma/article/doi/ 10.1093/burnst/tkac028/6668137.DOI: 10.1093/burnst/tkac028.
|
| [25] |
FakouriA,RazaviZS,MohammedAT,et al.Applications of mesenchymal stem cell-exosome components in wound infection healing: new insights[J/OL].Burns Trauma,2024,12:tkae021[2025-04-07]. https://academic.oup.com/burnstrauma/article/doi/ 10.1093/burnst/tkae021/7731845.DOI: 10.1093/burnst/tkae021.
|
| [26] |
LauHC,HanDW,ParkJ,et al.GMP-compliant manufacturing of biologically active cell-derived vesicles produced by extrusion technology[J].J Extracell Biol,2022,1(12):e70.DOI: 10.1002/jex2.70.
|
| [27] |
LingS,ZhangX,DaiY,et al.Customizable virus-like particles deliver CRISPR-Cas9 ribonucleoprotein for effective ocular neovascular and Huntington's disease gene therapy[J]. Nat Nanotechnol,2025,20(4):543-553.DOI: 10.1038/s41565-024-01851-7.
|
| [28] |
HeX,WangD,YiY,et al.δ-Tocotrienol preconditioning improves the capability of bone marrow-derived mesenchymal stem cells in promoting wound healing by inhibiting BACH1-related ferroptosis[J].Cell Death Discov,2023,9(1):349.DOI: 10.1038/s41420-023-01653-1.
|
| [29] |
MilasinovicS,LiuY,GasperGL,et al.Ultrashort pulse laser ablation for depth profiling of bacterial biofilms[J].J Vac Sci Technol A,2010,28(4):647-651.DOI: 10.1116/1.3397736.
|
| [30] |
WuS,XuC,ZhuY,et al.Biofilm‐sensitive photodynamic nanoparticles for enhanced penetration and antibacterial efficiency[J].Adv Funct Mater,2021,31(33):2103591. DOI: 10.1002/adfm.202103591.
|
| [31] |
WangS,ZhaoY,BreslawecAP,et al.Strategy to combat biofilms: a focus on biofilm dispersal enzymes[J].NPJ Biofilms Microbiomes,2023,9(1):63.DOI: 10.1038/s41522-023-00427-y.
|
| [32] |
Ali AghaASA,Al-SamydaiA,AburjaiT.New frontiers in CRISPR: addressing antimicrobial resistance with Cas9, Cas12, Cas13, and Cas14[J].Heliyon,2025,11(2):e42013. DOI: 10.1016/j.heliyon.2025.e42013.
|
| [33] |
BarzegariA,KheyrolahzadehK,Hosseiniyan KhatibiSM,et al.The battle of probiotics and their derivatives against biofilms[J].Infect Drug Resist,2020,13:659-672.DOI: 10.2147/IDR.S232982.
|
| [34] |
KaisthaSD,DeshpandeN.Traditional probiotics, next-generation probiotics and engineered live biotherapeutic products in chronic wound healing[M]//Kumar P,Kothari V.Wound healing research. Singapore: Springer Singapore,2021:247-284. DOI: 10.1007/978-981-16-2677-7_8.
|
| [35] |
AlexanderM,HuR,RuntschMC,et al.Exosome-delivered microRNAs modulate the inflammatory response to endotoxin[J].Nat Commun,2015,6:7321.DOI: 10.1038/ncomms8321.
|
| [36] |
NailHM,ChiuCC,LeungCH,et al.Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments[J].J Biomed Sci,2023,30(1):69.DOI: 10.1186/s12929-023-00964-w.
|
| [37] |
WitherelCE,AbebayehuD,BarkerTH,et al.Macrophage and fibroblast interactions in biomaterial-mediated fibrosis[J].Adv Healthc Mater,2019,8(4):e1801451.DOI: 10.1002/adhm.201801451.
|
| [38] |
ParkW,ParkS,ParkKY,et al.Long-term antioxidant metal-organic frameworks[J].ACS Omega,2024,9(19):21484-21493.DOI: 10.1021/acsomega.4c01993.
|
| [39] |
XuF,FeringaBL.Photoresponsive supramolecular polymers: from light-controlled small molecules to smart materials[J].Adv Mater,2023,35(10):e2204413.DOI: 10.1002/adma.202204413.
|
| [40] |
DevelL,CzarnyB,BeauF,et al.Third generation of matrix metalloprotease inhibitors: gain in selectivity by targeting the depth of the S1' cavity[J].Biochimie,2010,92(11):1501-1508.DOI: 10.1016/j.biochi.2010.07.017.
|
| [41] |
SchubertS,MarzloffG,RyderS,et al.Establishing a comprehensive wound care team and program[J].Phys Med Rehabil Clin N Am,2022,33(4):805-810.DOI: 10.1016/j.pmr.2022.06.006.
|
| [42] |
de AbreuVAC,PerdigãoJ,AlmeidaS.Metagenomic approaches to analyze antimicrobial resistance: an overview[J].Front Genet,2020,11:575592.DOI: 10.3389/fgene.2021.575592.
|
| [43] |
BrooksIR,SheriffA,MoranD,et al.Challenges of gene editing therapies for genodermatoses[J].Int J Mol Sci,2023,24(3):2298.DOI: 10.3390/ijms24032298.
|
| [44] |
董凯旋,李云贵,罗浩天,等.混合现实技术在股前外侧皮瓣修复四肢软组织缺损中的临床应用[J].中华显微外科杂志,2023,46(5):534-539.DOI: 10.3760/cma.j.cn441206-20230411-00066.
|
| [45] |
MusuuzaJ,SutherlandBL,KurterS,et al.A systematic review of multidisciplinary teams to reduce major amputations for patients with diabetic foot ulcers[J].J Vasc Surg,2020,71(4):1433-1446.e3.DOI: 10.1016/j.jvs.2019.08.244.
|
| [46] |
王丽薇,刘冰川,曲音音,等.多学科诊疗模式在慢性难愈合创面诊疗中的临床应用[J].北京大学学报(医学版),2025,57(1):185-191.DOI: 10.19723/j.issn.1671-167X.2025.01.028.
|
| [47] |
周琴,王青,李双双,等.多专科综合干预在特重度烧伤患者整合治疗中的效果观察[J].中华烧伤杂志,2018,34(10):701-706.DOI: 10.3760/cma.j.issn.1009-2587.2018.10.010.
|
| [48] |
LavelleJ,SchastA,KerenR.Standardizing care processes and improving quality using pathways and continuous quality improvement[J].Curr Treat Options Peds,2015,1(4):347-358.DOI: 10.1007/s40746-015-0026-4.
|
| [49] |
MoningiS,PatkiA,PadhyN,et al.Enhanced recovery after surgery: an anesthesiologist's perspective[J].J Anaesthesiol Clin Pharmacol,2019,35(Suppl 1):S5-S13.DOI: 10.4103/joacp.JOACP_238_16.
|
| [50] |
MelnykM,CaseyRG,BlackP,et al.Enhanced recovery after surgery (ERAS) protocols: time to change practice?[J].Can Urol Assoc J,2011,5(5):342-348.DOI: 10.5489/cuaj.11002.
|