Analysis of epidemiological characteristics and treatment of wounds in pediatric patients with hematologic malignancies

Zhu Hai; Liu Ziyu; Guo Chunlai; Chen Kun

doi:10.3760/cma.j.cn501225-20250623-00278

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > > Accepted Manuscript

Zhu Hai,Liu Ziyu,Guo Chunlai,et al.Analysis of epidemiological characteristics and treatment of wounds in pediatric patients with hematologic malignancies[J].Chin J Burns Wounds,2026,42(11):1-9.DOI: 10.3760/cma.j.cn501225-20250623-00278.

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Analysis of epidemiological characteristics and treatment of wounds in pediatric patients with hematologic malignancies

doi: 10.3760/cma.j.cn501225-20250623-00278

Zhu Hai¹,
Liu Ziyu¹,
Guo Chunlai¹,
Chen Kun^{1, 2
,
,}

1.
Department of Plastic and Reconstructive Surgery, Shunyi Maternal and Children's Hospital of Beijing Children's Hospital, Beijing 101399, China
2.
Department of Burns and Plastic Surgery, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China

Funds:

Beijing High-level Innovation and Entrepreneurship Talent Support Program G20250419

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Corresponding author: Chen Kun, Email: chenkun97@126.com
Received Date: 2025-06-23
Available Online: 2026-11-06

Abstract

Abstract

Objective To explore the epidemiological characteristics and treatment of wounds in pediatric patients with hematologic malignancies. Methods This study was a retrospective case series study. From January 2017 to December 2024, 20 and 12 pediatric patients with hematologic malignancies meeting the inclusion criteria were admitted to Beijing Children's Hospital of Capital Medical University and Shunyi Maternal and Children's Hospital of Beijing Children's Hospital, respectively, yielding a total of 41 wounds. The following data were recorded, including gender, age, and type of hematologic malignancy of pediatric patients, wound etiology, location, time of onset, area, depth, presence of tumor invasion, concurrent infection, treatment modality, healing time, and whether the wound resulted in chemotherapy delay. According to the wound depth, the wounds were divided into superficial wound group (30 wounds) and deep wound group (11 wounds), and wound concurrent infection, presence of tumor invasion, treatment modality, healing time, and whether the wound resulted in chemotherapy delay were compared. According to the presence of tumor invasion, the wounds were divided into tumor-involved wound group (11 wounds) and ordinary wound group (30 wounds), and wound concurrent infection, depth, treatment modality, healing time, and whether the wound resulted in chemotherapy delay were compared. According to the treatment modality, the wounds were divided into surgical treatment group (23 wounds) and conservative treatment group (18 wounds), and wound depth, presence of tumor invasion, concurrent infection, healing time, and whether the wound resulted in chemotherapy delay were compared. Results Among the 32 pediatric patients, 19 were males and 13 were females, aged 2.0 to 12.5 years; 16 were diagnosed with non-Hodgkin lymphoma, 2 with acute myeloid leukemia, and 14 with acute lymphoblastic leukemia. Six wounds were iatrogenic and 35 wounds were non-iatrogenic. Nine, 9, 11, and 12 wounds involved the head, face and neck, trunk, extremities, and buttocks and perineum, respectively. Ten wounds appeared before chemotherapy, and 31 wounds appeared during chemotherapy. The wound area was 15.00 (4.00, 48.00) cm². Thirty wounds were superficial wounds, and 11 wounds were deep wounds. Eleven wounds showed tumor invasion, and 31 wounds had concurrent infection. Eighteen wounds received conservative treatment, and 23 wounds received surgical treatment. The wound healing time was 70.00 (38.50, 103.00) days. Twenty-seven wounds resulted in chemotherapy delay. There were no statistically significant differences between superficial wound group and deep wound group in concurrent wound infection, presence of tumor invasion, treatment modality, healing time, or whether the wound resulted in chemotherapy delay (P>0.05). The healing time of tumor-involved wound group was significantly longer than that in ordinary wound group (U=78.50, P<0.05). The percentages of concurrent infection and chemotherapy delay in surgical treatment group were significantly higher than that in conservative treatment group (P<0.05), with a significantly shorter healing time (U=112.00, P<0.05). Conclusions In pediatric patients with hematologic malignancies, wounds are mostly non-iatrogenic, with frequent concurrent infection and prolonged healing time. Because the presence of wounds frequently delays oncologic treatment, early identification and prompt treatment of wounds for which surgery is indicated are essential, and surgical treatment can accelerate wound healing.
- Child,
- Hematologic neoplasms,
- Wound Healing,
- Wound infection,
- Epidemiology,
- Immunosuppression

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References(38)

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