The therapeutic effect of early enteral nutrition togather with recombinant human growth hormone on severely scalded rats

GUO Guang-hua; WU Chou-lang; LI Guo-hui; YU Yu-rong; Cai Chen

doi:10.3760/cma.j.issn.1009-2587.2003.Z1.115

Volume 19 Issue Z1

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2003 > 19(Z1): 33-36

GUO Guang-hua, WU Chou-lang, LI Guo-hui, et al. The therapeutic effect of early enteral nutrition togather with recombinant human growth hormone on severely scalded rats[J]. Chin j Burns, 2003, 19(Z1): 33-36. Doi: 10.3760/cma.j.issn.1009-2587.2003.Z1.115

Citation:

PDF( 1549 KB)

The therapeutic effect of early enteral nutrition togather with recombinant human growth hormone on severely scalded rats

doi: 10.3760/cma.j.issn.1009-2587.2003.Z1.115

1. Deportment of burns The First Affiliated Hospital of Jiangxi Medical College, Nanchang, 330006 Jiangxi Province, P. R. China

Available Online: 2021-10-28
Publish Date: 2003-11-20

Abstract

Abstract

Objective To evaluak the therapeutic effects of early enteral nutrition ( EEN ) togather with recombinant human growth hormone ( rhGH) on severely scalded rats. Methods One hundred and thirty Wistar rats were randomly divided into four groups, i. e. normal ( group N , n = 10) ,control( group C,n =40) , early enteral nutrition(group EEN , n =40) and early enteral nutrition with rhGH ( group EEN + rhGH ,n =40). The rats in C, EEN and EEN + rhGH groups were subgected to 30% TBSA Ⅲ degree scald on the back. The changes in body weight, hemoglobin, white blood cell count, total protein, albumin, morphology of ileal mucosa, serum levels of endotoxin and TNFα were observed on 1 ,3,5,9 postburn day ( PBD). Results (1 ) The rat body weight in C group decreased significantly ( P <0.05~0.01 ), while that in EEN+ rhGH group recovered more rapidly than that in other groups. ( 2 ) The serum endotoxin levels in EEN and EEN + rhGH groups were lower than that in C group( P <0.01), while that in EEN + rhGH groups was slightly lower than that in EEN group. (3) The serum TNFa levels in EEN group and EEN + rhGH group were lower than that in C group ( P <0.01) , while that in EEN + rhGH group was lower than that in EEN group on 3 and 9 postburn days( PBDs) ( P <0.05 ~0.01) . (4) The serum levels of total protein in EEN+ rhGH group was higher than that in EEN group on 9 PBD( P < 0.05). (5) The serum levels of albumin and blood hemoglobin levels exhibited no obvious differences among all the groups. (6) Intestinal mucosal injury and necrosis were only observed in C group. Imflammatory reaction was observed in EEN group, and the villous height in EEN + rhGH group was obviously higher than that in the other groups. Conclusion The structure and function of intestine in severely scalded rats could be maintained and the hypermetabolism reaction could be alleviated by early enteral nutrition, and EEN togather with rhGH seemed fohave better resulls than that of EEN alone.
- Scald,
- Early enteral nutrition,
- Recombinant human growth hormone,
- Endotoxin,
- Tumor necrosis factor-α,
- Intestinal mucosa

FullText(HTML)

References(0)

References

Relative Articles

[1]	Pan Yanyan, Xu Sida, Fan Youfen, Tu Jing, Huang Neng, Yu Yaohua, Cui Shengyong, Le Xin, Xu Pei, Jin Guoying, Chen Cui. Analysis of risk factors of early enteral nutrition intolerance in extremely severe burn patients[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2021, 37(9): 831-838. doi: 10.3760/cma.j.cn501120-20210511-00180
[2]	Wu Dan, Wang Chao, Li Teng, Wang Huan, Hu Jianhong, Peng Xi. Study on the effect and mechanism of recombinant human intestinal trefoil factor on intestinal mucosal injury and repair in burned mice[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2021, 37(9): 811-820. doi: 10.3760/cma.j.cn501120-20210412-00125
[3]	WANG Pei, ZHAO Yun, QI Hua-bing, YI Dong, WANG Feng-jun, WANG Shi-liang, PENG Xi. Effects of panthenol-glutamine on intestine of rats with burn injury and its dose-effect relationship[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2013, 29(4): 338-343. doi: 10.3760/cma.j.issn.1009-2587.2013.04.003
[4]	CHENG Jun-tao, WEI Zhi-yi, LIU Ding-jing, ZHANG Yong, LI Xiao- yi, CHEN Zhao-hong, XIAO Guang-xia. Influence of haemoxygenas(HO-1) gene expression on intestinal mucosa injury induced by intra- abdominal hypertension in rats[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2013, 29(3): 239-244. doi: 10.3760/cma.j.issn.1009-2587.2013.03.005
[6]	WANG Feng-jun. Research on intestinal tight junction barrier dysfunction should be emphasized in burn injury[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2010, 26(5): 331-333. doi: 10.3760/cma.j.issn.1009-2587.2010.05.002
[7]	ZHAO Ke-sen. Alteration in intestinal epithelial permeability and its role in the pathogenesis of burn shock[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2010, 26(5): 327-330. doi: 10.3760/cma.j.issn.1009-2587.2010.05.001
[8]	HU Quan, HU Sen, CHAI Jia-ke, SHEN Xiao-peng, CHE Jin-wei, SHENG Zhi-yong. Influence of enteral administration of hypertonic electrolyte glucose solution on the intestinal barrier and organ functions in dogs with severe burn[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2010, 26(1): 41-44. doi: 10.3760/cma.j.issn.1009-2587.2010.01.014
[10]	ZHAO Yun, WANG Feng-jun, WANG Pei, CHEN Yu, WANG Shi-liang. The protective effect of recombinant glucagons like peptide-2 on intestinal mucosa of burn rats[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2007, 23(4): 253-256.
[11]	GUO Li, WANG Xi-bin, YANG Yan, TONG Ting-hui. Influence of lipopolysaccharide and burn sera on ion channels in smooth muscle cells of colon of guinea pig[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2006, 22(3): 184-186.
[12]	CHENG Jun-tao, XIAO Guang-xia, FENG Zhi, LI Xiao-yi. Experimental study on injury to intestinal mucosal barrier induced by high intraperitoneal pressure[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2006, 22(2): 83-87.
[13]	RONG Xin-zhou, ZHANG Tao, YANG Rong-hua, HUANG Xiao-hua, LI Qing-hui. Morphological changes in intestinal villi after severe burns in rats[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2005, 21(6): 459-461.
[14]	GUO Li, SHI Ze-hong, ZHANG Hua-bin, HAN Bin-sheng, LIU Zheng-yu, LIU Cheng-rong, TONG Ting-hui. Influence of scald and lipopolysaccharide on gastrointestinal motility[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2005, 21(5): 350-352.
[15]	WANG Xiao-jun, SUN Yong-hua, WANG Jian-ning, DING Qin-xue, ZHANG Li-ping, SONG Guo-cheng, XIAO-Hong.. Influence of hyperoxic fluid on the down-regulated proteins of intestinal mucosa in scalded rats[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2005, 21(1): 60-62.
[17]	WANG Zhong-tang, YAO Yong-ming, XIAO Guang-xia, SHENG Zhi-yong. The protective effect of supplementation of probiotics combined with riboflavin on the intestinal barrier of the rats after scald injury[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2004, 20(4): 202-205.
[18]	MING jia, LlU Xu-sheng, LIU Liang, XU Hui, RAN Xin-ze, CHENG Tian-min. Effect of lipopolysacharide on the biological features and growth factor secretion power of U937 cell line[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2004, 20(2): 92-94.
[19]	WANG Qiang, PENG Yi-zhi. Study on the anti-maturation features of immature dendritic cells induced by low dosage of granulocyte macrophage colony stimulating factor[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2004, 20(6): 327-329.
[20]	ZHA0 Yun, WANG Feng-jun, WANG Pei, WANG Shi-liang. An experimental study on the relationship between the extracellular matrix and apoptosis of intestinal epithelium after burn injury[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2004, 20(4): 214-216.

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (115) PDF downloads(0)

The therapeutic effect of early enteral nutrition togather with recombinant human growth hormone on severely scalded rats

doi: 10.3760/cma.j.issn.1009-2587.2003.Z1.115

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

The therapeutic effect of early enteral nutrition togather with recombinant human growth hormone on severely scalded rats

doi: 10.3760/cma.j.issn.1009-2587.2003.Z1.115

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content