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Volume 39 Issue 1
Jan.  2023
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2023  >  39(1): 85-90
Ju YK,Fang BR.Research advances on the mechanism of extracellular vesicles of adipose-derived mesenchymal stem cells in promoting wound angiogenesis[J].Chin J Burns Wounds,2023,39(1):85-90.DOI: 10.3760/cma.j.cn501225-20220322-00080.
Citation: Ju YK,Fang BR.Research advances on the mechanism of extracellular vesicles of adipose-derived mesenchymal stem cells in promoting wound angiogenesis[J].Chin J Burns Wounds,2023,39(1):85-90.DOI: 10.3760/cma.j.cn501225-20220322-00080.
shu

Research advances on the mechanism of extracellular vesicles of adipose-derived mesenchymal stem cells in promoting wound angiogenesis

doi: 10.3760/cma.j.cn501225-20220322-00080

  • Department of Plastic and Aesthetic (Burn) Surgery, the Second Xiangya Hospital, Central South University, Changsha 410011, China

Funds:

Natural Science Foundation of Hunan Provincial of China 2021JJ30928

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    Abstract
  • Wound healing involves complex pathophysiological mechanism, among which angiogenesis is considered as one of the key steps in wound healing, and promoting wound angiogenesis can accelerate wound healing. In recent years, mesenchymal stem cell-derived extracellular vesicles have been proven to produce equivalent effects of wound healing promotion comparable to stem cell therapy, with the advantages of low antigenicity and high biocompatibility. The specific mechanism by which extracellular vesicles facilitate wound healing is still not fully understood and is thought to involve all stages of wound healing. This article focuses on the possible mechanism of extracellular vesicles of adipose-derived mesenchymal stem cells in promoting wound angiogenesis, so as to provide ideas for further study on the mechanism of extracellular vesicles to promote wound healing.

     

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  • [1]
    FuX.Wound healing center establishment and new technology application in improving the wound healing quality in China[J/OL].Burns Trauma,2020,8:tkaa038[2022-03-22].https://pubmed.ncbi.nlm.nih.gov/33134399/.DOI: 10.1093/burnst/tkaa038.
    [2]
    NagelkerkeA,OjansivuM,van der KoogL,et al.Extracellular vesicles for tissue repair and regeneration: evidence, challenges and opportunities[J].Adv Drug Deliv Rev,2021,175:113775.DOI: 10.1016/j.addr.2021.04.013.
    [3]
    WangY,ChengL,ZhaoH,et al.The therapeutic role of ADSC-EVs in skin regeneration[J].Front Med (Lausanne),2022,9:858824.DOI: 10.3389/fmed.2022.858824.
    [4]
    LindleyLE,StojadinovicO,PastarI,et al.Biology and biomarkers for wound healing[J].Plast Reconstr Surg,2016,138(3 Suppl):18S-28S.DOI: 10.1097/PRS.0000000000002682.
    [5]
    GurtnerGC,WernerS,BarrandonY,et al.Wound repair and regeneration[J].Nature,2008,453(7193):314-321.DOI: 10.1038/nature07039.
    [6]
    BroughtonG, JanisJE, AttingerCE. Wound healing: an overview[J].Plast Reconstr Surg,2006,117(7 Suppl): 1e-S-32e-S. DOI: 10.1097/01.prs.0000222562.60260.f9.
    [7]
    SorgH,TilkornDJ,MirastschijskiU,et al.Panta Rhei: neovascularization, angiogenesis and nutritive perfusion in wound healing[J].Eur Surg Res,2018,59(3/4):232-241.DOI: 10.1159/000492410.
    [8]
    DiPietroLA.Angiogenesis and wound repair: when enough is enough[J].J Leukoc Biol,2016,100(5):979-984.DOI: 10.1189/jlb.4MR0316-102R.
    [9]
    KochS,Claesson-WelshL.Signal transduction by vascular endothelial growth factor receptors[J].Cold Spring Harb Perspect Med,2012,2(7):a006502.DOI: 10.1101/cshperspect.a006502.
    [10]
    MoensS,GoveiaJ,StaporPC,et al.The multifaceted activity of VEGF in angiogenesis-Implications for therapy responses[J].Cytokine Growth Factor Rev,2014,25(4):473-482.DOI: 10.1016/j.cytogfr.2014.07.009.
    [11]
    GuerraA,BelinhaJ,JorgeRN.Modelling skin wound healing angiogenesis: a review[J].J Theor Biol,2018,459:1-17.DOI: 10.1016/j.jtbi.2018.09.020.
    [12]
    LiA,DubeyS,VarneyML,et al.IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis[J].J Immunol,2003,170(6):3369-3376.DOI: 10.4049/jimmunol.170.6.3369.
    [13]
    MaJ,WangQ,FeiT,et al.MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration[J].Blood,2007,109(3):987-994.DOI: 10.1182/blood-2006-07-036400.
    [14]
    TeichertM,MildeL,HolmA,et al.Pericyte-expressed Tie2 controls angiogenesis and vessel maturation[J].Nat Commun,2017,8:16106.DOI: 10.1038/ncomms16106.
    [15]
    PitulescuME,SchmidtI,GiaimoBD,et al.Dll4 and Notch signalling couples sprouting angiogenesis and artery formation[J].Nat Cell Biol,2017,19(8):915-927.DOI: 10.1038/ncb3555.
    [16]
    JingH,HeX,ZhengJ.Exosomes and regenerative medicine: state of the art and perspectives[J].Transl Res,2018,196:1-16.DOI: 10.1016/j.trsl.2018.01.005.
    [17]
    CaoY,GangX,SunC,et al.Mesenchymal stem cells improve healing of diabetic foot ulcer[J].J Diabetes Res,2017,2017:9328347.DOI: 10.1155/2017/9328347.
    [18]
    WongDE,BanyardDA,SantosP,et al.Adipose-derived stem cell extracellular vesicles: a systematic review☆[J].J Plast Reconstr Aesthet Surg,2019,72(7):1207-1218.DOI: 10.1016/j.bjps.2019.03.008.
    [19]
    ThéryC,WitwerKW,AikawaE,et al.Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines[J].J Extracell Vesicles,2018,7(1):1535750.DOI: 10.1080/20013078.2018.1535750.
    [20]
    HadeMD,SuireCN,MossellJ,et al.Extracellular vesicles: emerging frontiers in wound healing[J].Med Res Rev,2022,42(6):2102-2125.DOI: 10.1002/med.21918.
    [21]
    PomattoM,GaiC,NegroF,et al.Differential therapeutic effect of extracellular vesicles derived by bone marrow and adipose mesenchymal sStem cells on wound healing of diabetic ulcers and correlation to their cargoes[J].Int J Mol Sci,2021,22(8) :3851. DOI: 10.3390/ijms22083851.
    [22]
    Alonso-AlonsoML,García-PosadasL,DieboldY.Extracellular vesicles from human adipose-derived mesenchymal stem cells: a review of common cargos[J].Stem Cell Rev Rep,2022,18(3):854-901.DOI: 10.1007/s12015-021-10155-5.
    [23]
    GangadaranP,RajendranRL,OhJM,et al.Identification of angiogenic cargo in extracellular vesicles secreted from human adipose tissue-derived stem cells and induction of angiogenesis in vitro and in vivo[J].Pharmaceutics,2021,13(4):495.DOI: 10.3390/pharmaceutics13040495.
    [24]
    LamaliceL,Le BoeufF,HuotJ.Endothelial cell migration during angiogenesis[J].Circ Res,2007,100(6):782-794.DOI: 10.1161/01.RES.0000259593.07661.1e.
    [25]
    EirinA,ZhuXY,PuranikAS,et al.Comparative proteomic analysis of extracellular vesicles isolated from porcine adipose tissue-derived mesenchymal stem/stromal cells[J].Sci Rep,2016,6:36120.DOI: 10.1038/srep36120.
    [26]
    FiglioliniF,RanghinoA,GrangeC,et al.Extracellular vesicles from adipose stem cells prevent muscle damage and inflammation in a mouse model of hind limb ischemia: role of neuregulin-1[J].Arterioscler Thromb Vasc Biol,2020,40(1):239-254.DOI: 10.1161/ATVBAHA.119.313506.
    [27]
    PuCM,LiuCW,LiangCJ,et al.Adipose-derived stem cells protect skin flaps against ischemia/reperfusion injury via IL-6 expression[J].J Invest Dermatol,2017,137(6):1353-1362.DOI: 10.1016/j.jid.2016.12.030.
    [28]
    LiuW,YuanY,LiuD.Extracellular vesicles from adipose-derived stem cells promote diabetic wound healing via the PI3K-AKT-mTOR-HIF-1α signaling pathway[J].Tissue Eng Regen Med,2021,18(6):1035-1044.DOI: 10.1007/s13770-021-00383-8.
    [29]
    RenS,ChenJ,DuscherD,et al.Microvesicles from human adipose stem cells promote wound healing by optimizing cellular functions via AKT and ERK signaling pathways[J].Stem Cell Res Ther,2019,10(1):47.DOI: 10.1186/s13287-019-1152-x.
    [30]
    YuM,LiuW,LiJ,et al.Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway[J].Stem Cell Res Ther,2020,11(1):350.DOI: 10.1186/s13287-020-01824-2.
    [31]
    CapomaccioS,CappelliK,BazzucchiC,et al.Equine adipose-derived mesenchymal stromal cells release extracellular vesicles enclosing different subsets of small RNAs[J].Stem Cells Int,2019,2019:4957806.DOI: 10.1155/2019/4957806.
    [32]
    LiangX,ZhangL,WangS,et al.Exosomes secreted by mesenchymal stem cells promote endothelial cell angiogenesis by transferring miR-125a[J].J Cell Sci,2016,129(11):2182-2189.DOI: 10.1242/jcs.170373.
    [33]
    HuangB,HuangLF,ZhaoL,et al.Microvesicles (MIVs) secreted from adipose-derived stem cells (ADSCs) contain multiple microRNAs and promote the migration and invasion of endothelial cells[J].Genes Dis,2020,7(2):225-234.DOI: 10.1016/j.gendis.2019.04.005.
    [34]
    WeltenSM,GoossensEA,QuaxPH,et al.The multifactorial nature of microRNAs in vascular remodelling[J].Cardiovasc Res,2016,110(1):6-22.DOI: 10.1093/cvr/cvw039.
    [35]
    ZhuY,ZhangJ,HuX,et al.Extracellular vesicles derived from human adipose-derived stem cells promote the exogenous angiogenesis of fat grafts via the let-7/AGO1/VEGF signalling pathway[J].Sci Rep,2020,10(1):5313.DOI: 10.1038/s41598-020-62140-6.
    [36]
    PiL,YangL,FangBR,et al.Exosomal microRNA-125a-3p from human adipose-derived mesenchymal stem cells promotes angiogenesis of wound healing through inhibiting PTEN[J].Mol Cell Biochem,2022,477(1):115-127.DOI: 10.1007/s11010-021-04251-w.
    [37]
    KangT,JonesTM,NaddellC,et al.Adipose-derived stem cells Induce angiogenesis via microvesicle transport of miRNA-31[J].Stem Cells Transl Med,2016,5(4):440-450.DOI: 10.5966/sctm.2015-0177.
    [38]
    XuF,XiangQ,HuangJ,et al.Exosomal miR-423-5p mediates the proangiogenic activity of human adipose-derived stem cells by targeting Sufu[J].Stem Cell Res Ther,2019,10(1):106.DOI: 10.1186/s13287-019-1196-y.
    [39]
    LeeDY,DengZ,WangCH,et al.MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression[J].Proc Natl Acad Sci U S A,2007,104(51):20350-20355.DOI: 10.1073/pnas.0706901104.
    [40]
    卢颖洁人脂肪干细胞来源的外泌体通过miR-486-5p介导促进皮肤创面愈合的机制研究南昌南昌大学2020

    卢颖洁. 人脂肪干细胞来源的外泌体通过miR-486-5p介导促进皮肤创面愈合的机制研究[D].南昌:南昌大学, 2020.
    [41]
    HeoJS,KimS.Human adipose mesenchymal stem cells modulate inflammation and angiogenesis through exosomes[J].Sci Rep,2022,12(1):2776.DOI: 10.1038/s41598-022-06824-1.
    [42]
    HuangC,LuoW,WangQ,et al.Human mesenchymal stem cells promote ischemic repairment and angiogenesis of diabetic foot through exosome miRNA-21-5p[J].Stem Cell Res,2021,52:102235.DOI: 10.1016/j.scr.2021.102235.
    [43]
    DuL,LiG,YangY,et al.Exosomes from microRNA-199-3p-modified adipose-derived stem cells promote proliferation and migration of endothelial tip cells by downregulation of semaphorin 3A[J].Int J Clin Exp Pathol,2018,11(10):4879-4888.
    [44]
    QiuJ,ShuC,LiX,et al.Exosomes from linc00511-overexpressing ADSCs accelerates angiogenesis in diabetic foot ulcers healing by suppressing PAQR3-induced Twist1 degradation[J].Diabetes Res Clin Pract,2021,180:109032.DOI: 10.1016/j.diabres.2021.109032.
    [45]
    ShiR,JinY,HuW,et al.Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p/SIRT1-mediated autophagy[J].Am J Physiol Cell Physiol,2020,318(5):C848-C856.DOI: 10.1152/ajpcell.00041.2020.
    [46]
    LiX,XieX,LianW,et al.Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model[J].Exp Mol Med,2018,50(4):1-14.DOI: 10.1038/s12276-018-0058-5.
    [47]
    HettichBF,Ben-Yehuda GreenwaldM,WernerS,et al.Exosomes for wound healing: purification optimization and identification of bioactive components[J].Adv Sci (Weinh),2020,7(23):2002596.DOI: 10.1002/advs.202002596.
    [48]
    ZhangX,JiangY,HuangQ,et al.Exosomes derived from adipose-derived stem cells overexpressing glyoxalase-1 protect endothelial cells and enhance angiogenesis in type 2 diabetic mice with limb ischemia[J].Stem Cell Res Ther,2021,12(1):403.DOI: 10.1186/s13287-021-02475-7.
    [49]
    NanK,ZhangY,ZhangX,et al.Exosomes from miRNA-378-modified adipose-derived stem cells prevent glucocorticoid-induced osteonecrosis of the femoral head by enhancing angiogenesis and osteogenesis via targeting miR-378 negatively regulated suppressor of fused (Sufu)[J].Stem Cell Res Ther,2021,12(1):331.DOI: 10.1186/s13287-021-02390-x.
    [50]
    AnY,ZhaoJ,NieF,et al.Exosomes from adipose-derived stem cells (ADSCs) overexpressing miR-21 promote vascularization of endothelial cells[J].Sci Rep,2019,9(1):12861.DOI: 10.1038/s41598-019-49339-y.
    [51]
    TaoSC,GuoSC,LiM,et al.Chitosan wound dressings incorporating exosomes derived from microRNA-126-overexpressing synovium mesenchymal stem cells provide sustained release of exosomes and heal full-thickness skin defects in a diabetic rat model[J].Stem Cells Transl Med,2017,6(3):736-747.DOI: 10.5966/sctm.2016-0275.
    [52]
    HanY,RenJ,BaiY,et al.Exosomes from hypoxia-treated human adipose-derived mesenchymal stem cells enhance angiogenesis through VEGF/VEGF-R[J].Int J Biochem Cell Biol,2019,109:59-68.DOI: 10.1016/j.biocel.2019.01.017.
    [53]
    WuSC,KuoPJ,RauCS,et al.Increased angiogenesis by exosomes secreted by adipose-derived stem cells upon lipopolysaccharide stimulation[J].Int J Mol Sci,2021,22(16 ):8877. DOI: 10.3390/ijms22168877.
    [54]
    BaiY,HanYD,YanXL,et al.Adipose mesenchymal stem cell-derived exosomes stimulated by hydrogen peroxide enhanced skin flap recovery in ischemia-reperfusion injury[J].Biochem Biophys Res Commun,2018,500(2):310-317.DOI: 10.1016/j.bbrc.2018.04.065.
    [55]
    HuY,TaoR,ChenL,et al.Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis[J].J Nanobiotechnology,2021,19(1):150.DOI: 10.1186/s12951-021-00894-5.
    [56]
    XueC,ShenY,LiX,et al.Exosomes derived from hypoxia-treated human adipose mesenchymal stem cells enhance angiogenesis through the PKA signaling pathway[J].Stem Cells Dev,2018,27(7):456-465.DOI: 10.1089/scd.2017.0296.
    [57]
    RezaieJ,NejatiV,MahmoodiM,et al.Mesenchymal stem cells derived extracellular vesicles: a promising nanomedicine for drug delivery system[J].Biochem Pharmacol,2022,203:115167.DOI: 10.1016/j.bcp.2022.115167.
    [58]
    苏梦,王昕,张津,等.纳米细胞囊泡负载姜黄素促进糖尿病小鼠创面的愈合[J].中国组织工程研究,2023,27(12):1877-1883.
    [59]
    ChenJ,LiuR,HuangT,et al.Adipose stem cells-released extracellular vesicles as a next-generation cargo delivery vehicles: a survey of minimal information implementation, mass production and functional modification[J].Stem Cell Res Ther,2022,13(1):182.DOI: 10.1186/s13287-022-02849-5.
    [60]
    PatelDB,GrayKM,SantharamY,et al.Impact of cell culture parameters on production and vascularization bioactivity of mesenchymal stem cell-derived extracellular vesicles[J].Bioeng Transl Med,2017,2(2):170-179.DOI: 10.1002/btm2.10065.
    [61]
    DebbiL,GuoS,SafinaD,et al.Boosting extracellular vesicle secretion[J].Biotechnol Adv,2022,59:107983.DOI: 10.1016/j.biotechadv.2022.107983.
    [62]
    MaW,ZhangX,LiuY,et al.Polydopamine decorated microneedles with Fe-MSC-derived nanovesicles encapsulation for wound healing[J].Adv Sci (Weinh),2022,9(13):e2103317.DOI: 10.1002/advs.202103317.
    [63]
    AdayS,Hazan-HalevyI,Chamorro-JorganesA,et al.Bioinspired artificial exosomes based on lipid nanoparticles carrying let-7b-5p promote angiogenesis in vitro and in vivo[J].Mol Ther,2021,29(7):2239-2252.DOI: 10.1016/j.ymthe.2021.03.015.
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