New bioactive materials for promoting wound repair and skin regeneration

Lyu Guozhong; Zhao Peng

doi:10.3760/cma.j.cn501120-20211029-00373

Volume 37 Issue 12

Dec. 2021

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2021 > 37(12): 1105-1109

Lyu GZ,Zhao P.New bioactive materials for promoting wound repair and skin regeneration[J].Chin J Burns,2021,37(12):1105-1109.DOI: 10.3760/cma.j.cn501120-20211029-00373.

Citation:

Lyu GZ,Zhao P.New bioactive materials for promoting wound repair and skin regeneration[J].Chin J Burns,2021,37(12):1105-1109.DOI: 10.3760/cma.j.cn501120-20211029-00373.

Citation:

Lyu GZ,Zhao P.New bioactive materials for promoting wound repair and skin regeneration[J].Chin J Burns,2021,37(12):1105-1109.DOI: 10.3760/cma.j.cn501120-20211029-00373.

PDF( 882 KB)

New bioactive materials for promoting wound repair and skin regeneration

doi: 10.3760/cma.j.cn501120-20211029-00373

Lyu Guozhong^,,
Zhao Peng

Engineering Research Center of the Ministry of Education for Wound Repair Technology, Treatment Center of Burns and Trauma, the Affiliated Hospital of Jiangnan University, Wuxi 214122, China

Funds:

General Program of National Natural Science Foundation of China 81671912

Clinical Frontier Technology Program of Social Development of Science and Technology Agency of Jiangsu Province of China BE2018626

More Information

Corresponding author: Lyu Guozhong, Email: luguozhong@hotmail.com
Received Date: 2021-10-29

Abstract

Abstract

The modulation of microenvironment is a key technology towards promoting wound repair and skin regeneration. In recent years, a series of new bioactive materials that modulate the microenvironment and cell behaviors have been developed, demonstrating highly efficient capability of inducing wound repair and skin appendage regeneration. This article summarizes the research development of related new bioactive materials and their mechanisms of action.
- Biocompatible materials,
- Wound healing,
- Skin,
- Regeneration,
- Microenvironment

FullText(HTML)

References(40)

References

[1]	FinnertyCC,JeschkeMG,BranskiLK,et al.Hypertrophic scarring: the greatest unmet challenge after burn injury[J].Lancet,2016,388(10052):1427-1436.DOI: 10.1016/S0140-6736(16)31406-4.
[2]	SenCK.Human wound and its burden: updated 2020 compendium of estimates[J].Adv Wound Care (New Rochelle),2021,10(5):281-292.DOI: 10.1089/wound.2021.0026.
[3]	ClarkR.To scar or not to scar[J].N Engl J Med,2021,385(5):469-471.DOI: 10.1056/NEJMcibr2107204.
[4]	MooreAL,MarshallCD,BarnesLA,et al.Scarless wound healing: transitioning from fetal research to regenerative healing[J].Wiley Interdiscip Rev Dev Biol,2018,7(2): 10.1002/wdev.309.DOI: 10.1002/wdev.309.
[5]	CastañoO,Pérez-AmodioS,Navarro-RequenaC,et al.Instructive microenvironments in skin wound healing: biomaterials as signal releasing platforms[J].Adv Drug Deliv Rev,2018,129:95-117.DOI: 10.1016/j.addr.2018.03.012.
[6]	TracyLE,MinasianRA,CatersonEJ.Extracellular matrix and dermal fibroblast function in the healing wound[J].Adv Wound Care (New Rochelle),2016,5(3):119-136.DOI: 10.1089/wound.2014.0561.
[7]	程飚,付小兵.微环境控制是实现创面完美修复的必由之路[J].中华烧伤杂志,2020,36(11):1003-1008.DOI: 10.3760/cma.j.cn501120-20201009-00429.
[8]	HynesRO.The extracellular matrix: not just pretty fibrils[J].Science,2009,326(5957):1216-1219.DOI: 10.1126/science.1176009.
[9]	JulierZ,ParkAJ,BriquezPS,et al.Promoting tissue regeneration by modulating the immune system[J].Acta Biomater,2017,53:13-28.DOI: 10.1016/j.actbio.2017.01.056.
[10]	SunG.Pro-regenerative hydrogel restores scarless skin during cutaneous wound healing[J].Adv Healthc Mater,2017,6(23).DOI: 10.1002/adhm.201700659.
[11]	HaddadAG,GiatsidisG,OrgillDP,et al.Skin substitutes and bioscaffolds: temporary and permanent coverage[J].Clin Plast Surg,2017,44(3):627-634.DOI: 10.1016/j.cps.2017.02.019.
[12]	KraemerBA. Management of complex distal lower extremity wounds using a porcine urinary bladder matrix (UBM-ECM) [M]// Shiffman MA, Low M. Plastic and thoracic surgery, orthopedics and ophthalmology. Cham: Springer,2018: 3-29. DOI: 10.1007/15695_2017_60.
[13]	赵朋,杨敏烈,储国平,等.猪膀胱脱细胞基质和猪脱细胞真皮基质对糖尿病小鼠全层皮肤缺损创面愈合的影响[J].中华烧伤杂志,2020,36(12):1130-1138.DOI: 10.3760/cma.j.cn501120-20200901-00399.
[14]	HuleihelL,HusseyGS,NaranjoJD,et al.Matrix-bound nanovesicles within ECM bioscaffolds[J].Sci Adv,2016,2(6):e1600502.DOI: 10.1126/sciadv.1600502.
[15]	ValerioIL,CampbellP,SabinoJ,et al.The use of urinary bladder matrix in the treatment of trauma and combat casualty wound care[J].Regen Med,2015,10(5):611-622.DOI: 10.2217/rme.15.34.
[16]	HsuKF,ChiuYL,ChiaoHY,et al.Negative-pressure wound therapy combined with artificial dermis (Terudermis) followed by split-thickness skin graft might be an effective treatment option for wounds exposing tendon and bone: a retrospective observation study[J].Medicine (Baltimore),2021,100(14):e25395.DOI: 10.1097/MD.0000000000025395.
[17]	WolfMT, GangulyS, WangTL, et al. A biologic scaffold-associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy [J]. Sci Transl Med, 2019, 11(477): eaat7973. DOI: 10.1126/scitranslmed.aat7973.
[18]	WangX, ChungL, HooksJ, et al. Type 2 immunity induced by bladder extracellular matrix enhances corneal wound healing [J]. Sci Adv, 2021, 7(16): eabe2635. DOI: 10.1126/sciadv.abe2635.
[19]	GriffinDR,ArchangMM,KuanCH,et al.Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing[J].Nat Mater,2021,20(4):560-569.DOI: 10.1038/s41563-020-00844-w.
[20]	SadtlerK, SinghA, WolfM, et al. Design, clinical translation and immunological response of biomaterials in regenerative medicine [J]. Nat Rev Mater, 2016, 1(7): 16040. DOI: 10.1038/natrevmats.2016.40.
[21]	RinkevichY,WalmsleyGG,HuMS,et al.Skin fibrosis. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential[J].Science,2015,348(6232):aaa2151.DOI: 10.1126/science.aaa2151.
[22]	YannasIV,TzeranisDS,SoP.Regeneration of injured skin and peripheral nerves requires control of wound contraction, not scar formation[J].Wound Repair Regen,2017,25(2):177-191.DOI: 10.1111/wrr.12516.
[23]	GholipourmalekabadiM,KhosravimelalS,NokhbedehghanZ,et al.Modulation of hypertrophic scar formation using amniotic membrane/electrospun silk fibroin bilayer membrane in a rabbit ear model[J].ACS Biomater Sci Eng,2019,5(3):1487-1496.DOI: 10.1021/acsbiomaterials.8b01521.
[24]	GrasmanJM,WilliamsMD,RazisCG,et al.Hyperosmolar potassium inhibits myofibroblast conversion and reduces scar tissue formation[J].ACS Biomater Sci Eng,2019,5(10):5327-5336.DOI: 10.1021/acsbiomaterials.9b00810.
[25]	KalirajanC,PalanisamyT.A ZnO-curcumin nanocomposite embedded hybrid collagen scaffold for effective scarless skin regeneration in acute burn injury[J].J Mater Chem B,2019,7(38):5873-5886.DOI: 10.1039/c9tb01097a.
[26]	LiuX,MaL,LiangJ,et al.RNAi functionalized collagen-chitosan/silicone membrane bilayer dermal equivalent for full-thickness skin regeneration with inhibited scarring[J].Biomaterials,2013,34(8):2038-2048.DOI: 10.1016/j.biomaterials.2012.11.062.
[27]	SuN,GaoPL,WangK,et al.Fibrous scaffolds potentiate the paracrine function of mesenchymal stem cells: a new dimension in cell-material interaction[J].Biomaterials,2017,141:74-85.DOI: 10.1016/j.biomaterials.2017.06.028.
[28]	HanH,NingH,LiuS,et al.Silk biomaterials with vascularization capacity[J].Adv Funct Mater,2016,26(3):421-436.DOI: 10.1002/adfm.201504160.
[29]	XuY,PengJ,DongX,et al.Combined chemical and structural signals of biomaterials synergistically activate cell-cell communications for improving tissue regeneration[J].Acta Biomater,2017,55:249-261.DOI: 10.1016/j.actbio.2017.03.056.
[30]	LandryNM,DixonI.Fibroblast mechanosensing, SKI and Hippo signaling and the cardiac fibroblast phenotype: looking beyond TGF-β[J].Cell Signal,2020,76:109802.DOI: 10.1016/j.cellsig.2020.109802.
[31]	WangJH,ThampattyBP.An introductory review of cell mechanobiology[J].Biomech Model Mechanobiol,2006,5(1):1-16.DOI: 10.1007/s10237-005-0012-z.
[32]	AtchaH,JairamanA,HoltJR,et al.Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing[J].Nat Commun,2021,12(1):3256.DOI: 10.1038/s41467-021-23482-5.
[33]	LuuTU, LiuWF. Regulation of macrophages by extracellular matrix composition and adhesion geometry[J]. Regen Eng Transl Med, 2018, 4: 238-246. DOI: 10.1007/s40883-018-0065-z.
[34]	ChenK,KwonSH,HennD,et al.Disrupting biological sensors of force promotes tissue regeneration in large organisms[J].Nat Commun,2021,12(1):5256.DOI: 10.1038/s41467-021-25410-z.
[35]	YuJ,ZhangSS,SaitoK,et al.PTEN regulation by Akt-EGR1-ARF-PTEN axis[J].EMBO J,2009,28(1):21-33.DOI: 10.1038/emboj.2008.238.
[36]	ZhouF,HongY,LiangR,et al.Rapid printing of bio-inspired 3D tissue constructs for skin regeneration[J].Biomaterials,2020,258:120287.DOI: 10.1016/j.biomaterials.2020.120287.
[37]	KimBS,KwonYW,KongJS,et al.3D cell printing of in vitro stabilized skin model and in vivo pre-vascularized skin patch using tissue-specific extracellular matrix bioink: a step towards advanced skin tissue engineering[J].Biomaterials,2018,168:38-53.DOI: 10.1016/j.biomaterials.2018.03.040.
[38]	YaoB,WangR,WangY,et al.Biochemical and structural cues of 3D-printed matrix synergistically direct MSC differentiation for functional sweat gland regeneration[J].Sci Adv,2020,6(10):eaaz1094.DOI: 10.1126/sciadv.aaz1094.
[39]	MurrayRZ,WestZE,CowinAJ,et al.Development and use of biomaterials as wound healing therapies[J/OL].Burns Trauma,2019,7:2[2021-10-29].https://pubmed.ncbi.nlm.nih.gov/30701184/.DOI: 10.1186/s41038-018-0139-7.
[40]	GaharwarAK, SinghI, KhademhosseiniA. Engineered biomaterials for in situ tissue regeneration [J]. Nat Rev Mater, 2020, 5: 686-705. DOI: 10.1038/s41578-020-0209-x.

Relative Articles

[1]	Liu Huan, Aobuliaximu Yakupu, Jin Ronghua, Zhang Wei, Han Chunmao, Wang Xingang. Research advances on the application of recombinant human collagen biomaterials in the field of tissue engineering[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2025, 41(2): 188-194. doi: 10.3760/cma.j.cn501225-20240229-00081
[2]	Luo Gaoxing, Zhou Xuan. Application of advanced biomaterials in wound repair[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2024, 40(1): 26-32. doi: 10.3760/cma.j.cn501225-20231128-00211
[3]	Cai Chenghao, Han Chunmao, Wang Xingang. Research advances on the influence of wound external microenvironment factors on wound healing[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2024, 40(5): 489-494. doi: 10.3760/cma.j.cn501225-20230827-00067
[4]	Luo Gaoxing, Lu Yifei, Huang Can. Role of functional hydrogel in promoting wound healing[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2023, 39(1): 9-14. doi: 10.3760/cma.j.cn501225-20221123-00503
[5]	Liu Yifan, Jiang Zhaoqi, Huang Yao, Ni Pengwen, Xie Ting. Feasibility study on the preparation of novel negative pressure materials for constructing new matrix of full-thickness skin defect wounds in rats[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2022, 38(7): 650-660. doi: 10.3760/cma.j.cn501120-20210401-00113
[6]	Weng Tingting, Cai Chenghao, Han Chunmao, Wang Xingang. Research advances on biomaterials for the delivery of growth factors to regulate wound repair[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2022, 38(7): 691-696. doi: 10.3760/cma.j.cn501225-20220430-00166
[7]	Liu Lubing, Wen Huicai, Huang Jinjun, Xu Guizhen, Liao Huaiwei. Research advances on platelet-rich blood products combined with biological materials in wound repair[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2021, 37(4): 395-400. doi: 10.3760/cma.j.cn501120-20200531-00291
[8]	Luo Gaoxing, Liu Menglong. Application of functional materials to promote cutaneous wound healing[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2021, 37(11): 1005-1010. doi: 10.3760/cma.j.cn501120-20210930-00340
[9]	Liu Kaituo, Hu Dahai. Research advances on the application of biocompatible materials in treating diabetic wounds[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2021, 37(9): 885-886. doi: 10.3760/cma.j.cn501120-20200619-00316
[10]	Huang Yuesheng. Regulating bioelectric field and oxygen microenvironment to promote wound regeneration and repair[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2021, 37(1): 5-8. doi: 10.3760/cma.j.cn501120-20201123-00492
[11]	He Weifeng, Luo Gaoxing. Role of skin immunity on wound healing[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2020, 36(10): 901-904. doi: 10.3760/cma.j.cn501120-20200823-00389
[12]	Xin Yuewen, Chai Yanfen, Yao Yongming. Advances in the research of the relationship between skin regulatory T cells and wound healing and immune diseases[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2020, 36(2): 156-160. doi: 10.3760/cma.j.issn.1009-2587.2020.02.015
[13]	Hao Yi, Yang Qinxin, Wang Qi, Xu Guangchao, Qi Fang, Deng Chengliang, Wei Zairong, Wang Dali. Research on feasibility of in vitro inflammatory wound microenvironment simulated by using inflammatory wound tissue homogenate of mice[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2020, 36(11): 1024-1034. doi: 10.3760/cma.j.cn501120-20200720-00351
[14]	Cheng Biao, Fu Xiaobing. Microenvironment control is the only way to achieve perfect wound repair[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2020, 36(11): 1003-1008. doi: 10.3760/cma.j.cn501120-20201009-00429
[15]	Yao Bin, Xie Jiangfan, Huang Sha, Fu Xiaobing. Study on sweat gland regeneration induced by microenvironment of three-dimensional bioprinting[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2017, 33(1): 24-26. doi: 10.3760/cma.j.issn.1009-2587.2017.01.006
[16]	Fu Xiaobing. New challenge of tissue repair and regenerative medicine: to achieve a perfect repair and regeneration of multiple tissues in wound sites[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2016, 32(1): 6-10. doi: 10.3760/cma.j.issn.1009-2587.2016.01.003
[17]	HAN Chun-mao, WANG Xin-gang. Tissue engineered skin and regenerative wound repair[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2013, 29(2): 122-125. doi: 10.3760/cma.j.issn.1009-2587.2013.02.008
[18]	LUO Xu, XIN Guo-hua, ZENG Tao-fang, LIN Cai, ZENG Yuan-lin, LI Yu-cong, QIU Ze-liang. Effects of microporous porcine acellular dermal matrix combined with bone marrow mesenchymalcells of rats on the regeneration of cutaneous appendages cells in nude mice[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2013, 29(6): 541-547. doi: 10.3760/cma.j.issn.1009-2587.2013.06.012
[19]	LU Shu-liang, XIE Ting, NIU Yi-wen. A potential mechanism for impaired wound healing cutaneous environmental disorders in diabetes mellitus[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2008, 24(1): 3-5.
[20]	ZHOU Lai-sheng, LIAO Zhen-jiang, ZHANG Qin, LUO Min, LU Gang, ZHONG Wei. Bio-inductive effects of inorganic elements on skin wound healing[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2005, 21(5): 363-366.

Supplements(0)

Cited By

Cited by

Periodical cited type(2)

1.	潘玉雪，褚继萍，赵梦圆，常浩荡，陈红丽. 慢性难愈创面微环境响应型水凝胶材料的研究进展. 国际生物医学工程杂志. 2023(02): 151-155 .
2.	王敏，宋依强，罗洪琴. 生物防粘连膜与球囊联合宫内节育器在重度宫腔粘连术后应用的对比研究. 现代医药卫生. 2022(20): 3534-3536+3540 .

Other cited types(1)

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Tables(1)

Get Citation

PDF

XML

Article Metrics

Article views (683) PDF downloads(147)

New bioactive materials for promoting wound repair and skin regeneration

doi: 10.3760/cma.j.cn501120-20211029-00373