Re-understanding the physiological and pathophysiological roles of neutrophils

Sun Bingwei; Huang Jiamin

doi:10.3760/cma.j.cn501120-20211122-00391

Volume 38 Issue 2

Feb. 2022

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2022 > 38(2): 109-113

Sun BW,Huang JM.Re-understanding the physiological and pathophysiological roles of neutrophils[J].Chin J Burns Wounds,2022,38(2):109-113.DOI: 10.3760/cma.j.cn501120-20211122-00391.

Citation:

Sun BW,Huang JM.Re-understanding the physiological and pathophysiological roles of neutrophils[J].Chin J Burns Wounds,2022,38(2):109-113.DOI: 10.3760/cma.j.cn501120-20211122-00391.

Citation:

Sun BW,Huang JM.Re-understanding the physiological and pathophysiological roles of neutrophils[J].Chin J Burns Wounds,2022,38(2):109-113.DOI: 10.3760/cma.j.cn501120-20211122-00391.

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Re-understanding the physiological and pathophysiological roles of neutrophils

doi: 10.3760/cma.j.cn501120-20211122-00391

Sun Bingwei^,,
Huang Jiamin

Department of Burns and Plastic Surgery, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China

Funds:

Major Program of National Natural Science Foundation of China U21A20370

General Program of National Natural Science Foundation of China 82072217, 81772135

Special Program of Basic Research Plan (Natural Science Foundation) of Jiangsu Province of China BK20201178

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Corresponding author: Sun Bingwei, Email: sunbinwe@hotmail.com
Received Date: 2021-11-22

Abstract

Abstract

Neutrophils have always been considered as a short-lived and homogeneous cell type in the innate immune system, which have limited pro-inflammatory or anti-inflammatory effects. However, in recent 10 years, the understanding of neutrophils has been undergoing some kind of revival as researches progressed. The researches on the heterogeneity of neutrophils and the mechanism of their interaction with other immune cells have promoted the researchers to re-understand the physiological and pathophysiological roles of neutrophils. In the following decades, with the development of single-cell sequencing technology, spatial transcriptome sequencing technology, and multi-omics combined sequencing technology, researchers will have a better understanding of the biological behaviors of neutrophils. This paper briefly reviews the biological behaviors of neutrophils and their roles in various diseases in recent years.
- Cell death,
- Chemotaxis,
- Hetero- geneity,
- Neutrophils

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References

[1]	AmulicB, CazaletC, HayesGL, et al. Neutrophil function: from mechanisms to disease[J]. Annu Rev Immunol, 2012,30:459-489. DOI: 10.1146/annurev-immunol-020711-074942.
[2]	PetriB, SanzMJ. Neutrophil chemotaxis[J]. Cell Tissue Res, 2018,371(3):425-436. DOI: 10.1007/s00441-017-2776-8.
[3]	FoxS, LeitchAE, DuffinR, et al. Neutrophil apoptosis: relevance to the innate immune response and inflammatory disease[J]. J Innate Immun, 2010,2(3):216-227. DOI: 10.1159/000284367.
[4]	RobertsRE, HallettMB. Neutrophil cell shape change: mechanism and signalling during cell spreading and phagocytosis[J]. Int J Mol Sci, 2019,20(6):1383.DOI: 10.3390/ijms20061383.
[5]	MollinedoF. Neutrophil degranulation, plasticity, and cancer metastasis[J]. Trends Immunol, 2019,40(3):228-242. DOI: 10.1016/j.it.2019.01.006.
[6]	RosalesC. Neutrophils at the crossroads of innate and adaptive immunity[J]. J Leukoc Biol, 2020,108(1):377-396. DOI: 10.1002/JLB.4MIR0220-574RR.
[7]	KolaczkowskaE, KubesP. Neutrophil recruitment and function in health and inflammation[J]. Nat Rev Immunol, 2013,13(3):159-175. DOI: 10.1038/nri3399.
[8]	NavegantesKC, de Souza GomesR, PereiraPAT, et al. Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity[J]. J Transl Med, 2017,15(1):36. DOI: 10.1186/s12967-017-1141-8.
[9]	RosalesC. Neutrophil: a cell with many roles in inflammation or several cell types?[J]. Front Physiol, 2018,9:113. DOI: 10.3389/fphys.2018.00113.
[10]	LiewPX, KubesP. The neutrophil's role during health and disease[J]. Physiol Rev, 2019,99(2):1223-1248. DOI: 10.1152/physrev.00012.2018.
[11]	GalliSJ, BorregaardN, WynnTA. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils[J]. Nat Immunol, 2011,12(11):1035-1044. DOI: 10.1038/ni.2109.
[12]	Silvestre-RoigC, FridlenderZG, GlogauerM, et al. Neutrophil diversity in health and disease[J]. Trends Immunol, 2019,40(7):565-583. DOI: 10.1016/j.it.2019.04.012.
[13]	HellebrekersP, VrisekoopN, KoendermanL. Neutrophil phenotypes in health and disease[J]. Eur J Clin Invest, 2018,48 Suppl 2(Suppl Suppl 2):e12943. DOI: 10.1111/eci.12943.
[14]	XieX, ShiQ, WuP, et al. Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection[J]. Nat Immunol, 2020,21(9):1119-1133. DOI: 10.1038/s41590-020-0736-z.
[15]	QiX, YuY, SunR, et al. Identification and characterization of neutrophil heterogeneity in sepsis[J]. Crit Care, 2021,25(1):50. DOI: 10.1186/s13054-021-03481-0.
[16]	GieseMA, HindLE, HuttenlocherA. Neutrophil plasticity in the tumor microenvironment[J]. Blood, 2019,133(20):2159-2167. DOI: 10.1182/blood-2018-11-844548.
[17]	CarvalhoLO, AquinoEN, NevesAC, et al. The neutrophil nucleus and its role in neutrophilic function[J]. J Cell Biochem, 2015,116(9):1831-1836. DOI: 10.1002/jcb.25124.
[18]	MortazE, AlipoorSD, AdcockIM, et al. Update on neutrophil function in severe inflammation[J]. Front Immunol, 2018,9:2171. DOI: 10.3389/fimmu.2018.02171.
[19]	De FilippoK, RankinSM. CXCR4, the master regulator of neutrophil trafficking in homeostasis and disease[J]. Eur J Clin Invest, 2018,48 Suppl 2(Suppl Suppl 2):e12949. DOI: 10.1111/eci.12949.
[20]	UderhardtS, MartinsAJ, TsangJS, et al. Resident macrophages cloak tissue microlesions to prevent neutrophil-driven inflammatory damage[J]. Cell, 2019,177(3):541-555.e17. DOI: 10.1016/j.cell.2019.02.028.
[21]	SaffarzadehM, JuenemannC, QueisserMA, et al. Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones[J]. PLoS One, 2012,7(2):e32366. DOI: 10.1371/journal.pone.0032366.
[22]	WangX, QinW, XuX, et al. Endotoxin-induced autocrine ATP signaling inhibits neutrophil chemotaxis through enhancing myosin light chain phosphorylation[J]. Proc Natl Acad Sci U S A, 2017,114(17):4483-4488. DOI: 10.1073/pnas.1616752114.
[23]	YangY, LiuL, GuoZ, et al. A novel computer vision-based assessment of neutrophil chemotaxis in patients with severe infection[J]. Clin Transl Immunology, 2021,10(8):e1333. DOI: 10.1002/cti2.1333.
[24]	SpaanAN, SurewaardBG, NijlandR, et al. Neutrophils versus Staphylococcus aureus: a biological tug of war[J]. Annu Rev Microbiol, 2013,67:629-650. DOI: 10.1146/annurev-micro-092412-155746.
[25]	NowickaD, GrywalskaE. Staphylococcus aureus and host immunity in recurrent furunculosis[J]. Dermatology, 2019,235(4):295-305. DOI: 10.1159/000499184.
[26]	CurleyG, ContrerasMM, NicholAD, et al. Hypercapnia and acidosis in sepsis: a double-edged sword?[J]. Anesthesiology, 2010,112(2):462-472. DOI: 10.1097/ALN.0b013e3181ca361f.
[27]	MetzemaekersM, GouwyM, ProostP. Neutrophil chemoattractant receptors in health and disease: double-edged swords[J]. Cell Mol Immunol, 2020,17(5):433-450. DOI: 10.1038/s41423-020-0412-0.
[28]	LarsonRC, MausMV. Recent advances and discoveries in the mechanisms and functions of CAR T cells[J]. Nat Rev Cancer, 2021,21(3):145-161. DOI: 10.1038/s41568-020-00323-z.
[29]	MittalM, SiddiquiMR, TranK, et al. Reactive oxygen species in inflammation and tissue injury[J]. Antioxid Redox Signal, 2014,20(7):1126-1167. DOI: 10.1089/ars.2012.5149.
[30]	BenjaminJT, PlosaEJ, SucreJM, et al. Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD[J]. J Clin Invest, 2021,131(1):e139481.DOI: 10.1172/JCI139481.
[31]	CuiC, ChakrabortyK, TangXA, et al. Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis[J]. Cell, 2021,184(12):3163-3177.e21. DOI: 10.1016/j.cell.2021.04.016.
[32]	HuhSJ, LiangS, SharmaA, et al. Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development[J]. Cancer Res, 2010,70(14):6071-6082. DOI: 10.1158/0008-5472.CAN-09-4442.
[33]	TazzymanS, NiazH, MurdochC. Neutrophil-mediated tumour angiogenesis: subversion of immune responses to promote tumour growth[J]. Semin Cancer Biol, 2013,23(3):149-158. DOI: 10.1016/j.semcancer.2013.02.003.
[34]	GranotZ, HenkeE, ComenEA, et al. Tumor entrained neutrophils inhibit seeding in the premetastatic lung[J]. Cancer Cell, 2011,20(3):300-314. DOI: 10.1016/j.ccr.2011.08.012.
[35]	López-LagoMA, PosnerS, ThodimaVJ, et al. Neutrophil chemokines secreted by tumor cells mount a lung antimetastatic response during renal cell carcinoma progression[J]. Oncogene, 2013,32(14):1752-1760. DOI: 10.1038/onc.2012.201.
[36]	NjeimR, AzarWS, FaresAH, et al. NETosis contributes to the pathogenesis of diabetes and its complications[J]. J Mol Endocrinol, 2020,65(4):R65-R76. DOI: 10.1530/JME-20-0128.
[37]	WongSL, DemersM, MartinodK, et al. Diabetes primes neutrophils to undergo NETosis, which impairs wound healing[J]. Nat Med, 2015,21(7):815-819. DOI: 10.1038/nm.3887.
[38]	ScappaticcioL, MaiorinoMI, MaioA, et al. Neutropenia in patients with hyperthyroidism: systematic review and meta-analysis[J]. Clin Endocrinol (Oxf), 2021,94(3):473-483. DOI: 10.1111/cen.14313.
[39]	DrewW, WilsonDV, SapeyE. Inflammation and neutrophil immunosenescence in health and disease: targeted treatments to improve clinical outcomes in the elderly[J]. Exp Gerontol, 2018,105:70-77. DOI: 10.1016/j.exger.2017.12.020.
[40]	邱雨璐, 刘牧, 王灵冰, 等. 中性粒细胞免疫衰老与老年病的相关性研究进展[J].中国老年学杂志,2019,39(8):2019-2023.DOI: 10.3969/j.issn.1005-9202.2019.08.072.
[41]	SapeyE, GreenwoodH, WaltonG, et al. Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence[J]. Blood, 2014,123(2):239-248. DOI: 10.1182/blood-2013-08-519520.
[42]	SapeyE, PatelJM, GreenwoodHL, et al. Pulmonary infections in the elderly lead to impaired neutrophil targeting, which is improved by simvastatin[J]. Am J Respir Crit Care Med, 2017,196(10):1325-1336. DOI: 10.1164/rccm.201704-0814OC.
[43]	PatelJM, ThickettDR, GaoF, et al. Statins for sepsis: distinguishing signal from the noise when designing clinical trials[J]. Am J Respir Crit Care Med, 2013,188(7):874. DOI: 10.1164/rccm.201302-0392LE.
[44]	WangJ. Neutrophils in tissue injury and repair[J]. Cell Tissue Res, 2018,371(3):531-539. DOI: 10.1007/s00441-017-2785-7.
[45]	JunJI, KimKH, LauLF. The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing[J]. Nat Commun, 2015,6:7386. DOI: 10.1038/ncomms8386.
[46]	BrubakerAL, RendonJL, RamirezL, et al. Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age[J]. J Immunol, 2013,190(4):1746-1757. DOI: 10.4049/jimmunol.1201213.
[47]	NguyenKT, SethAK, HongSJ, et al. Deficient cytokine expression and neutrophil oxidative burst contribute to impaired cutaneous wound healing in diabetic, biofilm-containing chronic wounds[J]. Wound Repair Regen, 2013,21(6):833-841. DOI: 10.1111/wrr.12109.

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Re-understanding the physiological and pathophysiological roles of neutrophils

doi: 10.3760/cma.j.cn501120-20211122-00391

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Re-understanding the physiological and pathophysiological roles of neutrophils

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