| Citation: | He WF.Regulatory role and related mechanism of skin gamma-delta T cell subsets in wound re-epithelialization[J].Chin J Burns Wounds,2022,38(2):114-118.DOI: 10.3760/cma.j.cn501120-20211210-00411.
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Re-epithelialization is one of the core links that determines the healing process of skin wounds. The proliferation and differentiation of epidermal stem cells to form new epidermal tissue is the histological basis of re-epithelialization, and the smooth progress of the cell differentiation process of epidermal stem cells-precursor cells-terminal cells is the cytological basis for the continuous formation of new epidermal tissue. The proliferation of stem cells and their differentiation into precursor cells are the determinants of the proliferative potential of newly formed epidermal tissue, while the expansion and differentiation of precursor cells into terminal cells are key factors determining the rate of new epidermal tissue formation. The tissue microenvironment plays a key regulatory role in the process of wound re-epithelialization, and cell growth factor and inflammatory mediators are the two main components of tissue microenvironment, which play regulatory role in different aspects of proliferation and differentiation of epidermal stem cells, jointly promoting the smooth progress of wound re-epithelialization As an important part of skin immune system, the subsets of gamma-delta (γδ) T cells play crucial role in dynamically shaping early wound microenvironment via secreting different cell growth factors and inflammatory factors. From the prospective of immune microenvironment of wound, this paper discusses the role of skin γδ T cells in maintaining the balance of stem cell proliferation and differentiation and regulating wound re-epithelialization, providing a new direction for the prevention and treatment of refractory wound.
| [1] |
MacLeodAS,HemmersS,GarijoO,et al.Dendritic epidermal T cells regulate skin antimicrobial barrier function[J].J Clin Invest,2013,123(10):4364-4374.DOI: 10.1172/JCI70064.
|
| [2] |
MunozLD,SweeneyMJ,JamesonJM.Skin resident γδ T Cell function and regulation in wound repair[J].Int J Mol Sci,2020, 21(23):9286 DOI: 10.3390/ijms21239286.
|
| [3] |
ReinkeJM, SorgH. Wound repair and regeneration[J]. Eur Surg Res,2012,49(1):35-43. DOI: 10.1159/000339613.
|
| [4] |
KucharzewskiM,RojczykE,Wilemska-KucharzewskaK,et al.Novel trends in application of stem cells in skin wound healing[J].Eur J Pharmacol,2019,843:307-315.DOI: 10.1016/j.ejphar.2018.12.012.
|
| [5] |
YangR,LiuF,WangJ,et al.Epidermal stem cells in wound healing and their clinical applications[J].Stem Cell Res Ther,2019,10(1):229.DOI: 10.1186/s13287-019-1312-z.
|
| [6] |
DekoninckS,BlanpainC.Stem cell dynamics, migration and plasticity during wound healing[J].Nat Cell Biol,2019,21(1):18-24.DOI: 10.1038/s41556-018-0237-6.
|
| [7] |
KanjiS,DasH.Advances of stem cell therapeutics in cutaneous wound healing and regeneration[J].Mediators Inflamm,2017,2017:5217967.DOI: 10.1155/2017/5217967.
|
| [8] |
YangR,WangJ,ChenX,et al.Epidermal stem cells in wound healing and regeneration[J].Stem Cells Int,2020,2020:9148310.DOI: 10.1155/2020/9148310.
|
| [9] |
XiaoT,YanZ,XiaoS,et al.Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization[J].Stem Cell Res Ther,2020,11(1):232.DOI: 10.1186/s13287-020-01755-y.
|
| [10] |
LiY,WuJ,LuoG,et al.Functions of Vγ4 T cells and dendritic epidermal T cells on skin wound healing[J].Front Immunol,2018,9:1099.DOI: 10.3389/fimmu.2018.01099.
|
| [11] |
SharpLL,JamesonJM,CauviG,et al.Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1[J].Nat Immunol,2005,6(1):73-79.DOI: 10.1038/ni1152.
|
| [12] |
ChenWY,RogersAA.Recent insights into the causes of chronic leg ulceration in venous diseases and implications on other types of chronic wounds[J].Wound Repair Regen,2007,15(4):434-449.DOI: 10.1111/j.1524-475X.2007.00250.x.
|
| [13] |
FrykbergRG,BanksJ.Challenges in the treatment of chronic wounds[J].Adv Wound Care (New Rochelle),2015,4(9):560-582.DOI: 10.1089/wound.2015.0635.
|
| [14] |
KhannaS,BiswasS,ShangY,et al.Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice[J].PLoS One,2010,5(3):e9539.DOI: 10.1371/journal.pone.0009539.
|
| [15] |
JanuszykM,SorkinM,GlotzbachJP,et al.Diabetes irreversibly depletes bone marrow-derived mesenchymal progenitor cell subpopulations[J].Diabetes,2014,63(9):3047-3056.DOI: 10.2337/db13-1366.
|
| [16] |
LermanOZ,GalianoRD,ArmourM,et al.Cellular dysfunction in the diabetic fibroblast: impairment in migration, vascular endothelial growth factor production, and response to hypoxia[J].Am J Pathol,2003,162(1):303-312.DOI: 10.1016/S0002-9440(10)63821-7.
|
| [17] |
RodriguesM,KosaricN,BonhamCA,et al.Wound healing: a cellular perspective[J].Physiol Rev,2019,99(1):665-706.DOI: 10.1152/physrev.00067.2017.
|
| [18] |
XiangJ,QiuM,ZhangH.Role of dendritic epidermal T cells in cutaneous carcinoma[J].Front Immunol,2020,11:1266.DOI: 10.3389/fimmu.2020.01266.
|
| [19] |
谈思怡,向征,徐艳,等.人γδ T细胞的抗肿瘤临床免疫治疗新进展[J].生命科学,2017,29(9):855-863.DOI: 10.13376/j.cbls/2017115.
|
| [20] |
ChodaczekG,PapannaV,ZalMA,et al.Body-barrier surveillance by epidermal γδ TCRs[J].Nat Immunol,2012,13(3):272-282.DOI: 10.1038/ni.2240.
|
| [21] |
EdelbaumD,MohamadzadehM,BergstresserPR,et al.Interleukin (IL)-15 promotes the growth of murine epidermal gamma delta T cells by a mechanism involving the beta- and gamma c-chains of the IL-2 receptor[J].J Invest Dermatol,1995,105(6):837-843.DOI: 10.1111/1523-1747.ep12326630.
|
| [22] |
XuY,DimitrionP,CvetkovskiS,et al.Epidermal resident γδ T cell development and function in skin[J].Cell Mol Life Sci,2021,78(2):573-580.DOI: 10.1007/s00018-020-03613-9.
|
| [23] |
陈成,胡晓红,梁光萍,等.DETC在创面愈合过程中对炎症反应的调控作用及机制研究进展[J/CD].中华细胞与干细胞杂志:电子版,2020,10(6):378-382.DOI: 10.3877/cma.j.issn.2095-1221.2020.06.011.
|
| [24] |
LiY,WangY,ZhouL,et al.Vγ4 T cells inhibit the pro-healing functions of dendritic epidermal T cells to delay skin wound closure through IL-17A[J].Front Immunol,2018,9:240.DOI: 10.3389/fimmu.2018.00240.
|
| [25] |
LiuZ,LiangG,GuiL,et al.Weakened IL-15 production and impaired mTOR activation alter dendritic epidermal T cell homeostasis in diabetic mice[J].Sci Rep,2017,7(1):6028.DOI: 10.1038/s41598-017-05950-5.
|
| [26] |
BodurC,KazykenD,HuangK,et al.The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists[J].EMBO J,2018,37(1):19-38.DOI: 10.15252/embj.201696164.
|
| [27] |
ChoML,KangJW,MoonYM,et al.STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist- deficient mice[J].J Immunol,2006,176(9):5652-5661.DOI: 10.4049/jimmunol.176.9.5652.
|
| [28] |
ChenY,ZhangX,LiuZ,et al.Obstruction of the formation of granulation tissue leads to delayed wound healing after scald burn injury in mice[J/OL].Burns Trauma,2021,9:tkab004 [2022-01-21]. https://pubmed.ncbi.nlm.nih.gov/34212057.DOI: 10.1093/burnst/tkab004.
|
| [29] |
Muñoz-RuizM,SumariaN,PenningtonDJ,et al.Thymic determinants of γδ T cell differentiation[J].Trends Immunol,2017,38(5):336-344.DOI: 10.1016/j.it.2017.01.007.
|
| [30] |
GiriS,LalG.Differentiation and functional plasticity of gamma-delta (γδ) T cells under homeostatic and disease conditions[J].Mol Immunol,2021,136:138-149.DOI: 10.1016/j.molimm.2021.06.006.
|
| [31] |
RoderoMP,HodgsonSS,HollierB,et al.Reduced Il17a expression distinguishes a Ly6cloMHCIIhi macrophage population promoting wound healing[J].J Invest Dermatol,2013,133(3):783-792.DOI: 10.1038/jid.2012.368.
|
| [32] |
MillsRE,TaylorKR,PodshivalovaK,et al.Defects in skin gamma delta T cell function contribute to delayed wound repair in rapamycin-treated mice[J].J Immunol,2008,181(6):3974-3983.DOI: 10.4049/jimmunol.181.6.3974.
|
| [33] |
MartinP,NunanR.Cellular and molecular mechanisms of repair in acute and chronic wound healing[J].Br J Dermatol,2015,173(2):370-378.DOI: 10.1111/bjd.13954.
|
| [34] |
Ramírez-ValleF,GrayEE,CysterJG.Inflammation induces dermal Vγ4+ γδT17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses[J].Proc Natl Acad Sci U S A,2015,112(26):8046-8051.DOI: 10.1073/pnas.1508990112.
|
| [35] |
MaedaY,SekiN,KataokaH,et al.IL-17-producing Vγ4+ γδ T cells require sphingosine 1-phosphate receptor 1 for their egress from the lymph nodes under homeostatic and inflammatory conditions[J].J Immunol,2015,195(4):1408-1416.DOI: 10.4049/jimmunol.1500599.
|
| [36] |
RaverdeauM,CunninghamSP,HarmonC,et al.γδ T cells in cancer: a small population of lymphocytes with big implications[J].Clin Transl Immunology,2019,8(10):e01080.DOI: 10.1002/cti2.1080.
|
| [37] |
TengM,HuangY,ZhangH.Application of stems cells in wound healing--an update[J].Wound Repair Regen,2014,22(2):151-160.DOI: 10.1111/wrr.12152.
|
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He WF.Regulatory role and related mechanism of skin gamma-delta T cell subsets in wound re-epithelialization[J].Chin J Burns Wounds,2022,38(2):114-118.DOI: 10.3760/cma.j.cn501120-20211210-00411.
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