Email Alerts
RSS
Volume 38 Issue 12
Dec.  2022
Turn off MathJax
Article Contents
Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2022  >  38(12): 1190-1195
Sun TY,Lu F,Gao JH,et al.Progress on the mechanism and application of adipose-derived stem cells in promoting wound repair[J].Chin J Burns Wounds,2022,38(12):1190-1195.DOI: 10.3760/cma.j.cn501225-20220729-00320.
Citation: Sun TY,Lu F,Gao JH,et al.Progress on the mechanism and application of adipose-derived stem cells in promoting wound repair[J].Chin J Burns Wounds,2022,38(12):1190-1195.DOI: 10.3760/cma.j.cn501225-20220729-00320.
shu

Progress on the mechanism and application of adipose-derived stem cells in promoting wound repair

doi: 10.3760/cma.j.cn501225-20220729-00320

  • Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

Funds:

Youth Science Foundation Project of of National Natural Science Foundation of China 81801932

Guangdong Basic and Applied Basic Research Foundation 2022A1515011232

More Information
    Abstract
  • Chronic refractory wounds and scars caused by abnormal wound repair seriously damage the health of patients and affect their quality of life. At present, there is a lack of simple but effective and economical treatment methods. Adipose-derived stem cells (ASCs), as a kind of mesenchymal stem cells with multi-directional differentiation potential, have been confirmed by several in vivo and in vitro studies to promote wound healing by promoting epithelialization, angiogenesis, immunoregulation, antioxidant properties, and other mechanisms. ASCs and their derivatives have been used in the treatment of refractory wounds caused by burns, diabetic, and radiation injuries with good results achieved. Their potential to become new materials for wound repair has also been confirmed. This paper reviewed the mechanism and clinical application of ASCs in promoting wound repair, and looked into its research direction and prospects.

     

    • FullText(HTML)
  • loading
    • References(49)
  • [1]
    黄跃生,付小兵,陆树良,等.有关烧伤科与创面修复科协调发展的思考[J].中华烧伤杂志,2020,36(6):411-414.DOI: 10.3760/cma.j.cn501120-20200519-00273.
    [2]
    ZukPA,ZhuM,MizunoH,et al.Multilineage cells from human adipose tissue: implications for cell-based therapies[J].Tissue Eng,2001,7(2):211-228.DOI: 10.1089/107632701300062859.
    [3]
    AboulhodaBE,Abd El FattahS.Bone marrow-derived versus adipose-derived stem cells in wound healing: value and route of administration[J].Cell Tissue Res,2018,374(2):285-302.DOI: 10.1007/s00441-018-2879-x.
    [4]
    WiśniewskaJ, SłyszewskaM, StałanowskaK, et al. Effect of pig-adipose-derived stem cells' conditioned media on skin wound-healing characteristics in vitro[J]. Int J Mol Sci, 2021,22(11):5469. DOI: 10.3390/ijms22115469.
    [5]
    YuJ,WangMY,TaiHC,et al.Cell sheet composed of adipose-derived stem cells demonstrates enhanced skin wound healing with reduced scar formation[J].Acta Biomater,2018,77:191-200.DOI: 10.1016/j.actbio.2018.07.022.
    [6]
    RiisS,NewmanR,IpekH,et al.Hypoxia enhances the wound-healing potential of adipose-derived stem cells in a novel human primary keratinocyte-based scratch assay[J].Int J Mol Med,2017,39(3):587-594.DOI: 10.3892/ijmm.2017.2886.
    [7]
    RenS,ChenJ,DuscherD,et al.Microvesicles from human adipose stem cells promote wound healing by optimizing cellular functions via AKT and ERK signaling pathways[J].Stem Cell Res Ther,2019,10(1):47.DOI: 10.1186/s13287-019-1152-x.
    [8]
    NambuM,KishimotoS,NakamuraS,et al.Accelerated wound healing in healing-impaired db/db mice by autologous adipose tissue-derived stromal cells combined with atelocollagen matrix[J].Ann Plast Surg,2009,62(3):317-321.DOI: 10.1097/SAP.0b013e31817f01b6
    [9]
    ZhouX, NingK, LingB, et al. Multiple injections of autologous adipose-derived stem cells accelerate the burn wound healing process and promote blood vessel regeneration in a rat model[J]. Stem Cells Dev, 2019, 28(21):1463-1472. DOI: 10.1089/scd.2019.0113.
    [10]
    FoubertP,LiuM,AndersonS,et al.Preclinical assessment of safety and efficacy of intravenous delivery of autologous adipose-derived regenerative cells (ADRCs) in the treatment of severe thermal burns using a porcine model[J].Burns,2018,44(6):1531-1542.DOI: 10.1016/j.burns.2018.05.006.
    [11]
    ChenL,ZhengQ,LiuY,et al.Adipose-derived stem cells promote diabetic wound healing via the recruitment and differentiation of endothelial progenitor cells into endothelial cells mediated by the VEGF-PLCγ-ERK pathway[J].Arch Biochem Biophys,2020,692:108531.DOI: 10.1016/j.abb.2020.108531.
    [12]
    ZhangHZ,ChaeDS,KimSW.ASC and SVF cells synergistically induce neovascularization in ischemic hindlimb following cotransplantation[J].Int J Mol Sci,2021,23(1):185.DOI: 10.3390/ijms23010185.
    [13]
    IronsRF,CahillKW,RattiganDA,et al.Acceleration of diabetic wound healing with adipose-derived stem cells, endothelial-differentiated stem cells, and topical conditioned medium therapy in a swine model[J].J Vasc Surg,2018,68(6 Suppl):S115-125.DOI: 10.1016/j.jvs.2018.01.065.
    [14]
    HanYD,BaiY,YanXL,et al.Co-transplantation of exosomes derived from hypoxia-preconditioned adipose mesenchymal stem cells promotes neovascularization and graft survival in fat grafting[J].Biochem Biophys Res Commun,2018,497(1):305-312.DOI: 10.1016/j.bbrc.2018.02.076.
    [15]
    DeleonN,AdemS,LavinCV,et al.Angiogenic CD34+CD146+ adipose-derived stromal cells augment recovery of soft tissue after radiotherapy[J].J Tissue Eng Regen Med,2021,15(12):1105-1117.DOI: 10.1002/term.3253.
    [16]
    FujiwaraO,PrasaiA,Perez-BelloD,et al.Adipose-derived stem cells improve grafted burn wound healing by promoting wound bed blood flow[J/OL].Burns Trauma,2020,8:tkaa009[2022-07-29].https://pubmed.ncbi.nlm.nih.gov/32346539/.DOI: 10.1093/burnst/tkaa009.
    [17]
    ZhaoB, ZhangX, ZhangY, et al. Human exosomes accelerate cutaneous wound healing by promoting collagen synthesis in a diabetic mouse model[J]. Stem Cells Dev, 2021, 30(18):922-933. DOI: 10.1089/scd.2021.0100.
    [18]
    Al-GhadbanS,BunnellBA.Adipose tissue-derived stem cells: immunomodulatory effects and therapeutic potential[J].Physiology (Bethesda),2020,35(2):125-133.DOI: 10.1152/physiol.00021.2019.
    [19]
    KimWS,ParkBS,SungJH.The wound-healing and antioxidant effects of adipose-derived stem cells[J].Expert Opin Biol Ther,2009,9(7):879-887.DOI: 10.1517/14712590903039684.
    [20]
    XuJ,LiuX,ZhaoF,et al.HIF1α overexpression enhances diabetic wound closure in high glucose and low oxygen conditions by promoting adipose-derived stem cell paracrine function and survival[J].Stem Cell Res Ther,2020,11(1):148.DOI: 10.1186/s13287-020-01654-2.
    [21]
    XuP,XinY,ZhangZ,et al.Extracellular vesicles from adipose-derived stem cells ameliorate ultraviolet B-induced skin photoaging by attenuating reactive oxygen species production and inflammation[J].Stem Cell Res Ther,2020,11(1):264.DOI: 10.1186/s13287-020-01777-6.
    [22]
    GuiC,ParsonJ,MeyerGA.Harnessing adipose stem cell diversity in regenerative medicine[J].APL Bioeng,2021,5(2):021501.DOI: 10.1063/5.0038101.
    [23]
    Capella-MonsonísH,De PieriA,PeixotoR,et al.Extracellular matrix-based biomaterials as adipose-derived stem cell delivery vehicles in wound healing: a comparative study between a collagen scaffold and two xenografts[J].Stem Cell Res Ther,2020,11(1):510.DOI: 10.1186/s13287-020-02021-x.
    [24]
    BoQ, YanL, LiH, et al. Decellularized dermal matrix-based photo-crosslinking hydrogels as a platform for delivery of adipose derived stem cells to accelerate cutaneous wound healing[J]. Materials & Design, 2020, 196: 109152. DOI: 10.1016/j.matdes.2020.109152.
    [25]
    AzamM,GhufranH,ButtH,et al.Curcumin preconditioning enhances the efficacy of adipose-derived mesenchymal stem cells to accelerate healing of burn wounds[J/OL].Burns Trauma,2021,9:tkab021[2022-07-29].https://pubmed.ncbi.nlm.nih.gov/34514007/.DOI: 10.1093/burnst/tkab021.
    [26]
    AhmadiH,AminiA,Fadaei FathabadyF,et al.Transplantation of photobiomodulation-preconditioned diabetic stem cells accelerates ischemic wound healing in diabetic rats[J].Stem Cell Res Ther,2020,11(1):494.DOI: 10.1186/s13287-020-01967-2.
    [27]
    曹涛, 肖丹, 计鹏, 等. 肝细胞生长因子修饰的人脂肪间充质干细胞外泌体对糖尿病小鼠全层皮肤缺损的作用[J]. 中华烧伤与创面修复杂志, 2022, 38(11):1004-1013. DOI: 10.3760/cma.j.cn501225-20220731-00330.
    [28]
    PiccoloNS,PiccoloMS,PiccoloMT.Fat grafting for treatment of burns, burn scars, and other difficult wounds[J].Clin Plast Surg,2015,42(2):263-283.DOI: 10.1016/j.cps.2014.12.009.
    [29]
    GalS,RamirezJI,MaguinaP.Autologous fat grafting does not improve burn scar appearance: a prospective, randomized, double-blinded, placebo-controlled, pilot study[J].Burns,2017,43(3):486-489.DOI: 10.1016/j.burns.2016.09.019.
    [30]
    AbouzaidAM,El MokademME,AboubakrAK,et al.Effect of autologous fat transfer in acute burn wound management: a randomized controlled study[J].Burns,2022,48(6):1368-1385.DOI: 10.1016/j.burns.2021.10.011.
    [31]
    VriendL,van DongenJA,PijpeA,et al.Stromal vascular fraction-enriched fat grafting as treatment of adherent scars: study design of a non-randomized early phase trial[J].Trials,2022,23(1):575.DOI: 10.1186/s13063-022-06514-3.
    [32]
    LeeHC,AnSG,LeeHW,et al.Safety and effect of adipose tissue-derived stem cell implantation in patients with critical limb ischemia: a pilot study[J].Circ J,2012,76(7):1750-1760.DOI: 10.1253/circj.cj-11-1135.
    [33]
    MarinoG,MoraciM,ArmeniaE,et al.Therapy with autologous adipose-derived regenerative cells for the care of chronic ulcer of lower limbs in patients with peripheral arterial disease[J].J Surg Res,2013,185(1):36-44.DOI: 10.1016/j.jss.2013.05.024.
    [34]
    UzunE, GüneyA, GönenZB, et al. Intralesional allogeneic adipose-derived stem cells application in chronic diabetic foot ulcer: phase 1/2 safety study[J]. Foot Ankle Surg, 2021, 27(6): 636-642.DOI: https://doi.org/10.1016/j.fas.2020.08.002.
    [35]
    MoonKC, SuhHS, KimKB, et al. Potential of allogeneic adipose-derived stem cell-hydrogel complex for treating diabetic foot ulcers[J]. Diabetes, 2019, 68(4): 837-846. DOI: 10.2337/db18-0699.
    [36]
    LonardiR,LeoneN,GennaiS,et al.Autologous micro-fragmented adipose tissue for the treatment of diabetic foot minor amputations: a randomized controlled single-center clinical trial (MiFrAADiF)[J].Stem Cell Res Ther,2019,10(1):223.DOI: 10.1186/s13287-019-1328-4.
    [37]
    EjazA,EpperlyMW,HouW,et al.Adipose-derived stem cell therapy ameliorates ionizing irradiation fibrosis via hepatocyte growth factor-mediated transforming growth factor-β downregulation and recruitment of bone marrow cells[J].Stem Cells,2019,37(6):791-802.DOI: 10.1002/stem.3000.
    [38]
    YunIS,JeonYR,LeeWJ,et al.Effect of human adipose derived stem cells on scar formation and remodeling in a pig model: a pilot study[J].Dermatol Surg,2012,38(10):1678-1688.DOI: 10.1111/j.1524-4725.2012.02495.x.
    [39]
    BorrelliMR,PatelRA,AdemS,et al.The antifibrotic adipose-derived stromal cell: grafted fat enriched with CD74+ adipose-derived stromal cells reduces chronic radiation-induced skin fibrosis[J].Stem Cells Transl Med,2020,9(11):1401-1413.DOI: 10.1002/sctm.19-0317.
    [40]
    RigottiG,MarchiA,GalièM,et al.Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells[J].Plast Reconstr Surg,2007,119(5):1409-1422.DOI: 10.1097/01.prs.0000256047.47909.71.
    [41]
    GentilucciM, MazzocchiM, AlfanoC. Effects of prophylactic lipofilling after radiotherapy compared to non-fat injected breasts: a randomized, objective study.[J]. Aesthet Surg J, 2020, 40(10): NP597-NP607. DOI: 10.1093/asj/sjaa182.
    [42]
    KarmaliRJ,HansonSE,NguyenAT,et al.Outcomes following autologous fat grafting for oncologic head and neck reconstruction[J].Plast Reconstr Surg,2018,142(3):771-780.DOI: 10.1097/PRS.0000000000004686.
    [43]
    WuSH, ShiradoT, MashikoT, et al. Therapeutic effects of human adipose-derived products on impaired wound healing in irradiated tissue[J]. Plast Reconstr Surg,2018,142(2):383-391. DOI: 10.1097/PRS.0000000000004609.
    [44]
    YuD,ZhangS,MoW,et al.Transplantation of the stromal vascular fraction (SVF) mitigates severe radiation-induced skin injury[J].Radiat Res,2021,196(3):250-260.DOI: 10.1667/RADE-20-00156.1.
    [45]
    Kuca-WarnawinE,PlebańczykM,CiechomskaM,et al.Impact of adipose-derived mesenchymal stem cells (ASCs) of rheumatic disease patients on T helper cell differentiation[J].Int J Mol Sci,2022,23(10):5317.DOI: 10.3390/ijms23105317.
    [46]
    GongJH,DongJY,XieT,et al.Different therapeutic effects between diabetic and non-diabetic adipose stem cells in diabetic wound healing[J].J Wound Care,2021,30(Suppl 4):S14-23.DOI: 10.12968/jowc.2021.30.Sup4.S14.
    [47]
    SiennickaK,ZołocińskaA,DębskiT,et al.Comparison of the donor age-dependent and in vitro culture-dependent mesenchymal stem cell aging in rat model[J].Stem Cells Int,2021,2021:6665358.DOI: 10.1155/2021/6665358.
    [48]
    VargheseJ,GriffinM,MosahebiA,et al.Systematic review of patient factors affecting adipose stem cell viability and function: implications for regenerative therapy[J].Stem Cell Res Ther,2017,8(1):45.DOI: 10.1186/s13287-017-0483-8.
    [49]
    Prieto GonzálezEA. Heterogeneity in adipose stem cells[J]. Adv Exp Med Biol, 2019, 1123:119-150. DOI: 10.1007/978-3-030-11096-3_8.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (276) PDF downloads(43) Cited by()
    Proportional views
    Related

    Copyright © Chinese Journal of Burns京ICP备07035254号-14

    E-mail：shaoshangzazhi@163.com

    Website：https://zhsszz.xml-journal.net/

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return