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Volume 38 Issue 12
Dec.  2022
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2022  >  38(12): 1190-1195
Sun TY,Lu F,Gao JH,et al.Progress on the mechanism and application of adipose-derived stem cells in promoting wound repair[J].Chin J Burns Wounds,2022,38(12):1190-1195.DOI: 10.3760/cma.j.cn501225-20220729-00320.
Citation: Sun TY,Lu F,Gao JH,et al.Progress on the mechanism and application of adipose-derived stem cells in promoting wound repair[J].Chin J Burns Wounds,2022,38(12):1190-1195.DOI: 10.3760/cma.j.cn501225-20220729-00320.
shu

Progress on the mechanism and application of adipose-derived stem cells in promoting wound repair

doi: 10.3760/cma.j.cn501225-20220729-00320

  • Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

Funds:

Youth Science Foundation Project of of National Natural Science Foundation of China 81801932

Guangdong Basic and Applied Basic Research Foundation 2022A1515011232

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    Abstract
  • Chronic refractory wounds and scars caused by abnormal wound repair seriously damage the health of patients and affect their quality of life. At present, there is a lack of simple but effective and economical treatment methods. Adipose-derived stem cells (ASCs), as a kind of mesenchymal stem cells with multi-directional differentiation potential, have been confirmed by several in vivo and in vitro studies to promote wound healing by promoting epithelialization, angiogenesis, immunoregulation, antioxidant properties, and other mechanisms. ASCs and their derivatives have been used in the treatment of refractory wounds caused by burns, diabetic, and radiation injuries with good results achieved. Their potential to become new materials for wound repair has also been confirmed. This paper reviewed the mechanism and clinical application of ASCs in promoting wound repair, and looked into its research direction and prospects.

     

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