Research advances on the role of Schwann cells in diabetic peripheral neuropathy

Hao Tong; Cao Tao; Ji Peng; Zhang Weifeng; Tao Ke

doi:10.3760/cma.j.cn501225-20230727-00019

Volume 39 Issue 12

Dec. 2023

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2023 > 39(12): 1190-1194

Hao T,Cao T,Ji P,et al.Research advances on the role of Schwann cells in diabetic peripheral neuropathy[J].Chin J Burns Wounds,2023,39(12):1190-1194.DOI: 10.3760/cma.j.cn501225-20230727-00019.

Citation:

Hao T,Cao T,Ji P,et al.Research advances on the role of Schwann cells in diabetic peripheral neuropathy[J].Chin J Burns Wounds,2023,39(12):1190-1194.DOI: 10.3760/cma.j.cn501225-20230727-00019.

Citation:

Hao T,Cao T,Ji P,et al.Research advances on the role of Schwann cells in diabetic peripheral neuropathy[J].Chin J Burns Wounds,2023,39(12):1190-1194.DOI: 10.3760/cma.j.cn501225-20230727-00019.

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Research advances on the role of Schwann cells in diabetic peripheral neuropathy

doi: 10.3760/cma.j.cn501225-20230727-00019

Hao Tong¹,
Cao Tao²,
Ji Peng¹,
Zhang Weifeng³,
Tao Ke^{4
,
,}

1.
Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China
2.
The Second Department of Surgery, 63600 PLA Hospital, Jiuquan 735000, China
3.
Department of Biochemistry, College of Life Sciences, Shaanxi Normal University, Xi'an 710062, China
4.
Department of Wound Repair, Center for Wound Repair and Regenerative Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China

Funds:

General Program of National Natural Science Foundation of China 82272269

More Information

Corresponding author: Tao Ke, Email: tao-ke2001@163.com
Received Date: 2023-07-27
Available Online: 2023-12-19

Abstract

Abstract

Diabetic peripheral neuropathy (DPN) is one of the common chronic complications of diabetes, resulting in neuropathy of spinal nerve, cranial nerve, and vegetative nerve. Diabetic distal symmetric multiple neuropathy is the most representative lesion of DPN, including symptoms of bilateral limbs pain, numbness, and paresthesia, etc. DPN is one of the main reasons causing diabetic foot ulcer (DFU). Schwann cells (SCs) are the primary glia cells of the peripheral nervous system, which play very important role in repairing after nerve injury. As the target cells of chronic hyperglycemia, SCs' functions, including the formation of myelin sheath, the secretion of neurotrophic factors, energy supplying for the axon, and the guidance of axon regeneration, etc., are damaged under the action of high glucose. The destroyed functions of SCs can inhibit the repair of damaged nerves and accelerate the progress of DPN. Therefore, if the damage of high glucose to SCs can be effectively reduced, it will provide a new way for the treatment of DPN and DFU and reduce the morbidity of DFU. This review focuses on the function of SCs and its relationship with DPN.
- Diabetic foot,
- Myelin sheath,
- Diabetic peripheral neuropathy,
- Schwann cells,
- Neurotrophic factors,
- Energy supply,
- Axonal regeneration

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References(39)

References

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