Volume 40 Issue 5
May  2024
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Cai CH,Han CM,Wang XG.Research advances in the influence of wound external microenvironment factors on wound healing[J].Chin J Burns Wounds,2024,40(5):489-494.DOI: 10.3760/cma.j.cn501225-20230827-00067.
Citation: Cai CH,Han CM,Wang XG.Research advances in the influence of wound external microenvironment factors on wound healing[J].Chin J Burns Wounds,2024,40(5):489-494.DOI: 10.3760/cma.j.cn501225-20230827-00067.

Research advances on the influence of wound external microenvironment factors on wound healing

doi: 10.3760/cma.j.cn501225-20230827-00067
Funds:

National Key Research and Development Program of China 2022YFC2403100

General Program of National Natural Science Foundation of China 82172198

More Information
  • Wound microenvironment is directly related to the speed and quality of wound healing, and it is composed of various physical, chemical, and biological factors, and these factors are in a dynamic balance under normal conditions. In order to understand the effects of various physical, chemical, and biological factors on wound healing and to create microenvironment that can promote wound healing, this paper reviewed several wound external microenvironment factors including temperature, humidity, pH values, oxygen, microorganism, and biomechanics.

     

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  • [1]
    彭雨,孟浩,李品学,等.基于干细胞的组织工程修复材料促进体表慢性难愈合创面愈合的研究进展[J].中华烧伤与创面修复杂志,2023,39(3):290-295.DOI: 10.3760/cma.j.cn501225-20220407-00126.
    [2]
    黄跃生.调控生物电场与氧微环境促进创面再生修复[J].中华烧伤杂志,2021,37(1):5-8.DOI: 10.3760/cma.j.cn501120-20201123-00492.
    [3]
    KruseCR,NuutilaK,LeeCC,et al.The external microenvironment of healing skin wounds[J].Wound Repair Regen,2015,23(4):456-464.DOI: 10.1111/wrr.12303.
    [4]
    KirchnerS,LeiV,MacLeodAS.The cutaneous wound innate immunological microenvironment[J].Int J Mol Sci,2020,21(22):8748.DOI: 10.3390/ijms21228748.
    [5]
    Vélez GonzálezJJ,BergerM,SchieleS,et al.Dynamic optical coherence tomography of chronic venous ulcers[J].J Eur Acad Dermatol Venereol,2024,38(1):223-231.DOI: 10.1111/jdv.19496.
    [6]
    LouD,PangQ,PeiX,et al.Flexible wound healing system for pro-regeneration, temperature monitoring and infection early warning[J].Biosens Bioelectron,2020,162:112275.DOI: 10.1016/j.bios.2020.112275.
    [7]
    GethinG,IvoryJD,SezginD,et al.What is the "normal" wound bed temperature? A scoping review and new hypothesis[J].Wound Repair Regen,2021,29(5):843-847.DOI: 10.1111/wrr.12930.
    [8]
    El-AshramS,El-SamadLM,BashaAA,et al.Naturally-derived targeted therapy for wound healing: beyond classical strategies[J].Pharmacol Res,2021,170:105749.DOI: 10.1016/j.phrs.2021.105749.
    [9]
    SiahCR,ChildsC,ChiaCK,et al.An observational study of temperature and thermal images of surgical wounds for detecting delayed wound healing within four days after surgery[J].J Clin Nurs,2019,28(11/12):2285-2295.DOI: 10.1111/jocn.14832.
    [10]
    WuP,NelsonEA,ReidWH,et al.Water vapour transmission rates in burns and chronic leg ulcers: influence of wound dressings and comparison with in vitro evaluation[J].Biomaterials,1996,17(14):1373-1377.DOI: 10.1016/0142-9612(96)87277-2.
    [11]
    WinterGD.Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig[J].Nature,1962,193:293-294.DOI: 10.1038/193293a0.
    [12]
    JunkerJP,KamelRA,CatersonEJ,et al.Clinical impact upon wound healing and inflammation in moist, wet, and dry environments[J].Adv Wound Care (New Rochelle),2013,2(7):348-356.DOI: 10.1089/wound.2012.0412.
    [13]
    傅晓明,邢捷.创面外部微环境的中西医干预策略研究进展[J].中国中西医结合外科杂志,2023,29(1):120-124.DOI: 10.3969/j.issn.1007-6948.2023.01.024.
    [14]
    刘子怡,张旭娟,蔡子松,等.湿性愈合研究进展[J].生物技术进展,2023,13(4):534-541.DOI: 10.19586/j.2095-2341.2023.0010.
    [15]
    KongX,FuJ,ShaoK,et al.Biomimetic hydrogel for rapid and scar-free healing of skin wounds inspired by the healing process of oral mucosa[J].Acta Biomater,2019,100:255-269.DOI: 10.1016/j.actbio.2019.10.011.
    [16]
    GrolmanJM,SinghM,MooneyDJ,et al.Antibiotic-containing agarose hydrogel for wound and burn care[J].J Burn Care Res,2019,40(6):900-906.DOI: 10.1093/jbcr/irz113.
    [17]
    NuutilaK,ErikssonE.Moist wound healing with commonly available dressings[J].Adv Wound Care (New Rochelle),2021,10(12):685-698.DOI: 10.1089/wound.2020.1232.
    [18]
    SimP,StrudwickXL,SongY,et al.Influence of acidic pH on wound healing in vivo: a novel perspective for wound treatment[J].Int J Mol Sci,2022,23(21):13655.DOI: 10.3390/ijms232113655.
    [19]
    田瑞瑞,李娜,魏力.微环境pH值对创面愈合的作用研究进展[J].中华烧伤杂志,2016,32(4):240-242.DOI: 10.3760/cma.j.issn.1009-2587.2016.04.012.
    [20]
    王越,李贤,赵伟,等.Ⅲ期、Ⅳ期压疮愈合过程中创面pH值变化的研究[J].护理研究,2019,33(8):1379-1381.DOI: 10.12102/j.issn.1009-6493.2019.08.024.
    [21]
    王一如,白姣姣.微环境pH值对慢性创面愈合影响的研究进展[J].护理学杂志,2023,38(19):121-124.DOI: 10.3870/j.issn.1001-4152.2023.19.121.
    [22]
    ProkschE.pH in nature, humans and skin[J].J Dermatol,2018,45(9):1044-1052.DOI: 10.1111/1346-8138.14489.
    [23]
    SimP,SongY,YangGN,et al.In vitro wound healing properties of novel acidic treatment regimen in enhancing metabolic activity and migration of skin cells[J].Int J Mol Sci,2022,23(13):7188.DOI: 10.3390/ijms23137188.
    [24]
    PanQ,FanR,ChenR,et al.Weakly acidic microenvironment of the wound bed boosting the efficacy of acidic fibroblast growth factor to promote skin regeneration[J].Front Bioeng Biotechnol,2023,11:1150819.DOI: 10.3389/fbioe.2023.1150819.
    [25]
    TottoliEM,DoratiR,GentaI,et al.Skin wound healing process and new emerging technologies for skin wound care and regeneration[J].Pharmaceutics,2020,12(8):735.DOI: 10.3390/pharmaceutics12080735.
    [26]
    周璇,金琳博,张一鸣.氧微环境对急慢性创面愈合影响的研究进展[J].临床外科杂志,2022,30(12):1112-1114.DOI: 10.3969/j.issn.1005-6483.2022.12.004.
    [27]
    EisenbudDE.Oxygen in wound healing: nutrient, antibiotic, signaling molecule, and therapeutic agent[J].Clin Plast Surg,2012,39(3):293-310.DOI: 10.1016/j.cps.2012.05.001.
    [28]
    ChenX,ZhangL,ChaiW,et al.Hypoxic microenvironment reconstruction with synergistic biofunctional ions promotes diabetic wound healing[J].Adv Healthc Mater,2023,12(32):e2301984.DOI: 10.1002/adhm.202301984.
    [29]
    GuanY,NiuH,LiuZ,et al.Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation[J].Sci Adv,2021,7(35):eabj0153.DOI: 10.1126/sciadv.abj0153.
    [30]
    HuangX,LiangP,JiangB,et al.Hyperbaric oxygen potentiates diabetic wound healing by promoting fibroblast cell proliferation and endothelial cell angiogenesis[J].Life Sci,2020,259:118246.DOI: 10.1016/j.lfs.2020.118246.
    [31]
    DunnillC,PattonT,BrennanJ,et al.Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process[J].Int Wound J,2017,14(1):89-96.DOI: 10.1111/iwj.12557.
    [32]
    XuZ,HanS,GuZ,et al.Advances and impact of antioxidant hydrogel in chronic wound healing[J].Adv Healthc Mater,2020,9(5):e1901502.DOI: 10.1002/adhm.201901502.
    [33]
    MurphyMP,BayirH,BelousovV,et al.Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo[J].Nat Metab,2022,4(6):651-662.DOI: 10.1038/s42255-022-00591-z.
    [34]
    Tomic-CanicM,BurgessJL,O'NeillKE,et al.Skin microbiota and its interplay with wound healing[J].Am J Clin Dermatol,2020,21(Suppl 1):S36-43.DOI: 10.1007/s40257-020-00536-w.
    [35]
    Harris-TryonTA,GriceEA.Microbiota and maintenance of skin barrier function[J].Science,2022,376(6596):940-945.DOI: 10.1126/science.abo0693.
    [36]
    DarvishiS,TavakoliS,KharazihaM,et al.Advances in the sensing and treatment of wound biofilms[J].Angew Chem Weinheim Bergstr Ger,2022,134(13):e202112218.DOI: 10.1002/ange.202112218.
    [37]
    WuYK,ChengNC,ChengCM.Biofilms in chronic wounds: pathogenesis and diagnosis[J].Trends Biotechnol,2019,37(5):505-517.DOI: 10.1016/j.tibtech.2018.10.011.
    [38]
    WächterJ,VestweberPK,JungN,et al.Imitating the microenvironment of native biofilms using nanofibrous scaffolds to emulate chronic wound infections[J].J Mater Chem B,2023,11(14):3212-3225.DOI: 10.1039/d2tb02700c.
    [39]
    孙骞,魏强,赵长生.细胞怎样感知与响应微环境机械力学性能[J].科学通报,2021,66(18):2303-2311.DOI: 10.1360/TB-2020-1069.
    [40]
    DianD,BodungenV,HimslI,et al.Worldwide first experiences with vacuum-assisted closure as alternative treatment method to repair defects of an extended thoracic wall recurrence of breast cancer[J].Arch Gynecol Obstet,2010,281(5):927-932.DOI: 10.1007/s00404-009-1277-8.
    [41]
    李自军,李松军,黄志明.负压创面治疗技术在骨科的应用进展[J].齐齐哈尔医学院学报,2023,44(8):762-766.DOI: 10.3969/j.issn.1002-1256.2023.08.013.
    [42]
    LiuJ,HuF,TangJ,et al.Homemade-device-induced negative pressure promotes wound healing more efficiently than VSD-induced positive pressure by regulating inflammation, proliferation and remodeling[J].Int J Mol Med,2017,39(4):879-888.DOI: 10.3892/ijmm.2017.2919.
    [43]
    HuangX,LiangX,ZhouY,et al.CDH1 is identified as a therapeutic target for skin regeneration after mechanical loading[J].Int J Biol Sci,2021,17(1):353-367.DOI: 10.7150/ijbs.51309.
    [44]
    WangJ,ZhangY,GaoY,et al.EZH2 regulates the correlation between skin regeneration and the duration of mechanical stretch[J].J Invest Dermatol,2021,141(4):894-902.e9.DOI: 10.1016/j.jid.2020.09.007.
    [45]
    JoseM,BronckaersA,KumarR,et al.Stretchable printed device for the simultaneous sensing of temperature and strain validated in a mouse wound healing model[J].Sci Rep,2022,12(1):10138.DOI: 10.1038/s41598-022-13834-6.
    [46]
    YangJ,LiuX,WangW,et al.Bioelectric fields coordinate wound contraction and re-epithelialization process to accelerate wound healing via promoting myofibroblast transformation[J].Bioelectrochemistry,2022,148:108247.DOI: 10.1016/j.bioelechem.2022.108247.
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