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Volume 40 Issue 12
Dec.  2024
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2024  >  40(12): 1193-1198
Zhou ZY,Xu GC,Wang DL.Research advances on extracellular vesicles in promoting diabetic wound healing through the regulation of immune microenvironment[J].Chin J Burns Wounds,2024,40(12):1193-1198.DOI: 10.3760/cma.j.cn501225-20231215-00243.
Citation: Zhou ZY,Xu GC,Wang DL.Research advances on extracellular vesicles in promoting diabetic wound healing through the regulation of immune microenvironment[J].Chin J Burns Wounds,2024,40(12):1193-1198.DOI: 10.3760/cma.j.cn501225-20231215-00243.
shu

Research advances on extracellular vesicles in promoting diabetic wound healing through the regulation of immune microenvironment

doi: 10.3760/cma.j.cn501225-20231215-00243

  • Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi563003, China

Funds:

General Program of National Natural Science Foundation of China 82072195, 82472567

Collaborative Innovation Center of Chinese Ministry of Education and Guizhou Province 2020-39

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    Abstract
  • Peripheral neuropathy and poor blood circulation caused by long-term hyperglycemia in patients with diabetes often leads to foot wounds, ulcers, and gangrene, which accompanied by an imbalance in the wound immune microenvironment. Extracellular vesicle (EV) therapy is an emerging biologic treatment method. EV possesses advantages such as good biocompatibility, high efficacy, low immunogenicity, and low tissue toxicity. By modulating the immune responses and cellular functions in the microenvironment, EV can reduce inflammation levels in wounds, showing great potential in accelerating diabetic wound healing. This review summarizes the mechanism by which EV participates in regulating wound healing through the modulation of various inflammatory and non-inflammatory cells in the microenvironment of diabetic wounds, discusses the advantages and limitations of various approaches of the clinical translation of EV, proposes the concept of combining EV therapy with the disease microenvironment, thereby providing new insights for further researches on the clinical application of EV.

     

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  • [1]
    RodriguesM,KosaricN,BonhamCA,et al.Wound healing: a cellular perspective[J].Physiol Rev,2019,99(1):665-706.DOI: 10.1152/physrev.00067.2017.
    [2]
    PatelS,SrivastavaS,SinghMR,et al.Mechanistic insight into diabetic wounds: pathogenesis, molecular targets and treatment strategies to pace wound healing[J].Biomed Pharmacother,2019,112:108615.DOI: 10.1016/j.biopha.2019.108615.
    [3]
    AryanA,BayatM,BonakdarS,et al.Human bone marrow mesenchymal stem cell conditioned medium promotes wound healing in deep second-degree burns in male rats[J].Cells Tissues Organs,2018,206(6):317-329.DOI: 10.1159/000501651.
    [4]
    HuP,YangQ,WangQ,et al.Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regeneration[J/OL].Burns Trauma,2019,7:38[2023-12-15].https://pubmed.ncbi.nlm.nih.gov/31890717/. DOI: 10.1186/s41038-019-0178-8.
    [5]
    BianD, WuY, SongG, et al. The application of mesenchymal stromal cells (MSCs) and their derivative exosome in skin wound healing: a comprehensive review[J]. Stem Cell Res Ther, 2022,13(1):24. DOI: 10.1186/s13287-021-02697-9.
    [6]
    GesmundoI,PardiniB,GargantiniE,et al.Adipocyte-derived extracellular vesicles regulate survival and function of pancreatic β cells[J].JCI Insight,2021,6(5):e141962.DOI: 10.1172/jci.insight.141962.
    [7]
    HeX,DongZ,CaoY,et al.MSC-derived exosome promotes M2 polarization and enhances cutaneous wound healing[J].Stem Cells Int,2019,2019:7132708.DOI: 10.1155/2019/7132708.
    [8]
    YanC,ChenJ,WangC,et al.Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis[J].Drug Deliv,2022,29(1):214-228.DOI: 10.1080/10717544.2021.2023699.
    [9]
    HullCM,PeakmanM,TreeTIM.Regulatory T cell dysfunction in type 1 diabetes: what's broken and how can we fix it?[J].Diabetologia,2017,60(10):1839-1850.DOI: 10.1007/s00125-017-4377-1.
    [10]
    ZhangJ,XiaoY,HuJ,et al.Lipid metabolism in type 1 diabetes mellitus: pathogenetic and therapeutic implications[J].Front Immunol,2022,13:999108.DOI: 10.3389/fimmu.2022.999108.
    [11]
    ZhangQ,WangJ,YadavDK,et al.Glucose metabolism: the metabolic signature of tumor associated macrophage[J].Front Immunol,2021,12:702580.DOI: 10.3389/fimmu.2021.702580.
    [12]
    RaziyevaK,KimY,ZharkinbekovZ,et al.Immunology of acute and chronic wound healing[J].Biomolecules,2021,11(5):700.DOI: 10.3390/biom11050700.
    [13]
    DaiJ,ZhouY,MeiS,et al.Application of antibiotic bone cement in the treatment of infected diabetic foot ulcers in type 2 diabetes[J].BMC Musculoskelet Disord,2023,24(1):135.DOI: 10.1186/s12891-023-06244-w.
    [14]
    ArmstrongDG,TanTW,BoultonAJM,et al.Diabetic foot ulcers: a review[J].JAMA,2023,330(1):62-75.DOI: 10.1001/jama.2023.10578.
    [15]
    JiS,LiuX,HuangJ,et al.Consensus on the application of negative pressure wound therapy of diabetic foot wounds[J/OL].Burns Trauma,2021,9:tkab018[2023-12-15].https://pubmed.ncbi.nlm.nih.gov/34212064/.DOI: 10.1093/burnst/tkab018.
    [16]
    CheZ,YeZ,ZhangX,et al.Mesenchymal stem/stromal cells in the pathogenesis and regenerative therapy of inflammatory bowel diseases[J].Front Immunol,2022,13:952071.DOI: 10.3389/fimmu.2022.952071.
    [17]
    FujiiS,MiuraY.Immunomodulatory and regenerative effects of MSC-derived extracellular vesicles to treat acute GVHD[J].Stem Cells,2022,40(11):977-990.DOI: 10.1093/stmcls/sxac057.
    [18]
    ThéryC,WitwerKW,AikawaE,et al.Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines[J].J Extracell Vesicles,2018,7(1):1535750.DOI: 10.1080/20013078.2018.1535750.
    [19]
    RezaieJ,FeghhiM,EtemadiT.A review on exosomes application in clinical trials: perspective, questions, and challenges[J].Cell Commun Signal,2022,20(1):145.DOI: 10.1186/s12964-022-00959-4.
    [20]
    ZhouY,DuT,YangCL,et al.Extracellular vesicles encapsulated with caspase-1 inhibitor ameliorate experimental autoimmune myasthenia gravis through targeting macrophages[J].J Control Release,2023,364:458-472.DOI: 10.1016/j.jconrel.2023.11.006.
    [21]
    AndoY,MazzuranaL,ForkelM,et al.Downregulation of microRNA-21 in colonic CD3+ T cells in UC remission[J].Inflamm Bowel Dis,2016,22(12):2788-2793.DOI: 10.1097/MIB.0000000000000969.
    [22]
    WangL,WangC,JiaX,et al.Circulating exosomal miR-17 inhibits the induction of regulatory T cells via suppressing TGFBR II expression in rheumatoid arthritis[J].Cell Physiol Biochem,2018,50(5):1754-1763.DOI: 10.1159/000494793.
    [23]
    EbrahimkhaniS,VafaeeF,YoungPE,et al.Exosomal microRNA signatures in multiple sclerosis reflect disease status[J].Sci Rep,2017,7(1):14293.DOI: 10.1038/s41598-017-14301-3.
    [24]
    LakhterAJ,PrattRE,MooreRE,et al.Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes[J].Diabetologia,2018,61(5):1124-1134.DOI: 10.1007/s00125-018-4559-5.
    [25]
    JiangM,FangH,ShaoS,et al.Keratinocyte exosomes activate neutrophils and enhance skin inflammation in psoriasis[J].FASEB J,2019,33(12):13241-13253.DOI: 10.1096/fj.201900642R.
    [26]
    VasanthanJ,GurusamyN,RajasinghS,et al.Role of human mesenchymal stem cells in regenerative therapy[J].Cells,2020,10(1):54.DOI: 10.3390/cells10010054.
    [27]
    纪鸥洋,方均燕,宋阿会,等.间充质干细胞外泌体对腹膜间皮细胞高糖损伤的作用研究[J].组织工程与重建外科杂志,2022,18(4):294-299.DOI: 10.3969/j.issn.1673-0364.2022.04.002.
    [28]
    Shigemoto-KurodaT,OhJY,KimDK,et al.MSC-derived extracellular vesicles attenuate immune responses in two autoimmune murine models: type 1 diabetes and uveoretinitis[J].Stem Cell Reports,2017,8(5):1214-1225.DOI: 10.1016/j.stemcr.2017.04.008.
    [29]
    Dominguez-VillarM,HaflerDA.Regulatory T cells in autoimmune disease[J].Nat Immunol,2018,19(7):665-673.DOI: 10.1038/s41590-018-0120-4.
    [30]
    McClymontSA,PutnamAL,LeeMR,et al.Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes[J].J Immunol,2011,186(7):3918-3926.DOI: 10.4049/jimmunol.1003099.
    [31]
    FavaroE,CarpanettoA,CaorsiC,et al.Human mesenchymal stem cells and derived extracellular vesicles induce regulatory dendritic cells in type 1 diabetic patients[J].Diabetologia,2016,59(2):325-333.DOI: 10.1007/s00125-015-3808-0.
    [32]
    BoniakowskiAE,KimballAS,JacobsBN,et al.Macrophage-mediated inflammation in normal and diabetic wound healing[J].J Immunol,2017,199(1):17-24.DOI: 10.4049/jimmunol.1700223.
    [33]
    KomiDEA,KhomtchoukK,Santa MariaPL.A review of the contribution of mast cells in wound healing: involved molecular and cellular mechanisms[J].Clin Rev Allergy Immunol,2020,58(3):298-312.DOI: 10.1007/s12016-019-08729-w.
    [34]
    PortouMJ,BakerD,AbrahamD,et al.The innate immune system, toll-like receptors and dermal wound healing: a review[J].Vascul Pharmacol,2015,71:31-36.DOI: 10.1016/j.vph.2015.02.007.
    [35]
    DainichiT,KitohA,OtsukaA,et al.The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis[J].Nat Immunol,2018,19(12):1286-1298.DOI: 10.1038/s41590-018-0256-2.
    [36]
    LiuY,LiuY,HeW,et al.Fibroblasts: immunomodulatory factors in refractory diabetic wound healing[J].Front Immunol,2022,13:918223.DOI: 10.3389/fimmu.2022.918223.
    [37]
    孙锦,史宸硕,王达利.间充质干细胞外泌体在创面愈合和增生性瘢痕防治方面的研究进展[J].中华烧伤杂志,2021,37(5):495-500.DOI: 10.3760/cma.j.cn501120-20200410-00220.
    [38]
    TiD,HaoH,TongC,et al.LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b[J].J Transl Med,2015,13:308.DOI: 10.1186/s12967-015-0642-6.
    [39]
    NojehdehiS,SoudiS,HesampourA,et al.Immunomodulatory effects of mesenchymal stem cell-derived exosomes on experimental type-1 autoimmune diabetes[J].J Cell Biochem,2018,119(11):9433-9443.DOI: 10.1002/jcb.27260.
    [40]
    唐黎珺,张筱薇,金俊俊,等.脂肪源性间充质干细胞外泌体在慢性创面治疗中作用机制的研究进展[J].中华烧伤杂志,2021,37(2):191-195.DOI: 10.3760/cma.j.cn501120-20200220-00076.
    [41]
    WenD,PengY,LiuD,et al.Mesenchymal stem cell and derived exosome as small RNA carrier and immunomodulator to improve islet transplantation[J].J Control Release,2016,238:166-175.DOI: 10.1016/j.jconrel.2016.07.044.
    [42]
    WangS,LiG,LiangX,et al.Small extracellular vesicles derived from altered peptide ligand-loaded dendritic cell act as a therapeutic vaccine for spinal cord injury through eliciting CD4+ T cell-mediated neuroprotective immunity[J].Adv Sci (Weinh),2024,11(3):e2304648.DOI: 10.1002/advs.202304648.
    [43]
    ZhouC,ZhangB,YangY,et al.Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing[J].Stem Cell Res Ther,2023,14(1):107.DOI: 10.1186/s13287-023-03345-0.
    [44]
    付文,王向臣,王延桂,等.脂肪源性间充质干细胞外泌体在大鼠全层皮肤缺损创面愈合中的机制研究[J].组织工程与重建外科杂志,2023,19(4):342-351,379.DOI: 10.3969/j.issn.1673-0364.2023.04.003.
    [45]
    PomattoM,GaiC,NegroF,et al.Differential therapeutic effect of extracellular vesicles derived by bone marrow and adipose mesenchymal stem cells on wound healing of diabetic ulcers and correlation to their cargoes[J].Int J Mol Sci,2021,22(8):3851.DOI: 10.3390/ijms22083851.
    [46]
    ZhouX,BrownBA,SiegelAP,et al.Exosome-mediated crosstalk between keratinocytes and macrophages in cutaneous wound healing[J].ACS Nano,2020,14(10):12732-12748.DOI: 10.1021/acsnano.0c03064.
    [47]
    WuY,WuX,WangJ,et al.Fibroblast-derived extracellular vesicle-packaged long noncoding RNA upregulated in diabetic skin enhances keratinocyte MMP-9 expression and delays diabetic wound healing[J].Lab Invest,2023,103(3):100019.DOI: 10.1016/j.labinv.2022.100019.
    [48]
    WeiF,WangA,WangQ,et al.Plasma endothelial cells-derived extracellular vesicles promote wound healing in diabetes through YAP and the PI3K/Akt/mTOR pathway[J].Aging (Albany NY),2020,12(12):12002-12018.DOI: 10.18632/aging.103366.
    [49]
    ChenMd G,WuMd Y,ZouMd L,et al.Effect of microRNA-146a modified adipose-derived stem cell exosomes on rat back wound healing[J].Int J Low Extrem Wounds,2023,22(4):704-712.DOI: 10.1177/15347346211038092.
    [50]
    ShinKO,HaDH,KimJO,et al.Exosomes from human adipose tissue-derived mesenchymal stem cells promote epidermal barrier repair by inducing de novo synthesis of ceramides in atopic dermatitis[J].Cells,2020,9(3):680.DOI: 10.3390/cells9030680.
    [51]
    ZhangY,PanY,LiuY,et al.Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-β receptor inhibition[J].Stem Cell Res Ther,2021,12(1):434.DOI: 10.1186/s13287-021-02517-0.
    [52]
    陈涛,高绍莹,郝艺,等.人羊膜间充质干细胞外泌体通过微小RNA-135a促进成纤维细胞迁移实验研究[J].中国修复重建外科杂志,2020,34(2):234-239.DOI: 10.7507/1002-1892.201907136.
    [53]
    ZhangY,YanJ,LiuY,et al.Human amniotic fluid stem cell-derived exosomes as a novel cell-free therapy for cutaneous regeneration[J].Front Cell Dev Biol,2021,9:685873.DOI: 10.3389/fcell.2021.685873.
    [54]
    XiongY,LinZ,BuP,et al.A whole-course-repair system based on neurogenesis-angiogenesis crosstalk and macrophage reprogramming promotes diabetic wound healing[J].Adv Mater,2023,35(19):e2212300.DOI: 10.1002/adma.202212300.
    [55]
    GuC,LiY,LiuJ,et al.Neural stem cell-derived exosomes-loaded adhesive hydrogel controlled-release promotes cerebral angiogenesis and neurological function in ischemic stroke[J].Exp Neurol,2023,370:114547.DOI: 10.1016/j.expneurol.2023.114547.
    [56]
    ZhengW,RädlerJ,SorkH,et al.Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles[J].Nat Commun,2023,14(1):4734.DOI: 10.1038/s41467-023-40453-0.
    [57]
    KoKW,YooYI,KimJY,et al.Attenuation of tumor necrosis factor-α induced inflammation by umbilical cord-mesenchymal stem cell derived exosome-mimetic nanovesicles in endothelial cells[J].Tissue Eng Regen Med,2020,17(2):155-163.DOI: 10.1007/s13770-019-00234-7.
    [58]
    ZhangS,JiangL,HuH,et al.Pretreatment of exosomes derived from hUCMSCs with TNF-α ameliorates acute liver failure by inhibiting the activation of NLRP3 in macrophage[J].Life Sci,2020,246:117401.DOI: 10.1016/j.lfs.2020.117401.
    [59]
    LiuH,WangY,HouY,et al.Fitness of chassis cells and metabolic pathways for l-cysteine overproduction in escherichia coli[J].J Agric Food Chem,2020,68(50):14928-14937.DOI: 10.1021/acs.jafc.0c06134.
    [60]
    HanR, WuY, HanY, et al. Engineered plant extracellular vesicles for autoimmune diseases therapy[J]. Nano Research, 2023, 17(4):2857-2873. DOI: 10.1007/s12274-023-6112-1.
    [61]
    LiuH, SunJ, WangM, et al. Intestinal organoids and organoids extracellular vesicles for inflammatory bowel disease treatment[J]. Chemical Engineering Journal, 2023,465:142842. DOI: 10.1016/j.cej.2023.142842.
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