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Volume 40 Issue 5
May  2024
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2024  >  40(5): 433-442
Zhao JH,Lyu YH,Lei YH.Visualized analysis of research hotspots and evolutionary trends in the field of wound repair mechanism research[J].Chin J Burns Wounds,2024,40(5):433-442.DOI: 10.3760/cma.j.cn501225-20240118-00022.
Citation: Zhao JH,Lyu YH,Lei YH.Visualized analysis of research hotspots and evolutionary trends in the field of wound repair mechanism research[J].Chin J Burns Wounds,2024,40(5):433-442.DOI: 10.3760/cma.j.cn501225-20240118-00022.
shu

Visualized analysis of research hotspots and evolutionary trends in the field of wound repair mechanism research

doi: 10.3760/cma.j.cn501225-20240118-00022
  • 1.

    Institute of Wound Prevention and Treatment, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China

  • 2.

    School of Fundamental Medicine, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China

  • 3.

    School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China

Funds:

Shanghai Sailing Program 21YF1418800

The Construction Project of High-level Local Universities of Shanghai University of Medicine and Health Sciences E1-2601-23-201006

Shanghai Training Program for College Students' Innovation S202210262026

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    Abstract
  •   Objective  To explore the research hotspots and evolutionary trends in the field of wound repair mechanism research.  Methods  This study was a bibliometric analysis study. English literature related to wound repair mechanism published in the core collection of Web of Science database from the establishment of the database to December 26th, 2023 that met the inclusion criteria were retrieved. The annual number of publications and their citations were counted, and the change trend was analyzed. Based on the aforementioned annual publication volume, the relevant literature in the core collection of Web of Science database in this field from the first 5 years when the publication growth in this field was rapidly turning, to December 31st, 2023 was searched again, and the total number of publications was recorded and annual growth rate of published literature was calculated; and based on the trend line of annual publication volume, the publication volume in this field in 2024 was predicted. The CiteSpace 6.2.R4 software was used for visualized analysis of the literature from the second retrieval, including the source journals, the cited literature, and the keywords, to discuss the current research status and the evolution of hotspots of wound repair mechanism.  Results  The first search retrieved a total of 3 992 literature related to the research on wound repair mechanisms, among which the annual number of publications and their citations increased rapidly from 2015 to 2023. The time limit for the second retrieval was set to be from January 1st, 2011 to December 31st, 2023, during which a total of 3 206 literature was published, with an average annual growth rate of 13.30%. According to the publication trend line at this stage, it was predicted that the number of publications in this field will reach 500 in 2024. The literature from the second retrieval was published in 717 journals. The research directions of the top 10 journals with the most published literature (accounting for 18.75% (601/3 206) of the total number of publications) mainly focused on trauma, molecules, pharmacology of Chinese medicine, and stem cells, with the United Kingdom and the United States, etc. as the main publishing countries. There were 7 journals with impact factors >5 and 6 journals belonging to the Q1 or Q2 areas of the Chinese Academy of Sciences. There were 906 nodes and 9 large clusters for the keywords of cited literature of literature from the second retrieval (Q=0.64, S=0.82). The main clusters of cited literature of literature from the second retrieval were #2 matrix metalloproteinases and #3 transforming growth factor β1 from 2006 to 2015, #1 macrophage polarization, #4 mesenchymal stem cells, #6 antibacterial, and #7 plant extraction from 2016 to 2023. During 2021-2023, the main clusters of cited literature of literature from the second retrieval being #1 macrophage polarization, #4 mesenchymal stem cells, #6 antibacterial, and #7 plant extraction had the most closely related co-occurrence. The analysis of the top 5 cited literature of literature from the second retrieval with high citation value, high centrality value, and high Sigma value showed that the main research directions were the influence of macrophages and inflammation regulation on wound repair, the influence of fibroblasts on wound repair, and the influence of growth factors and cytokines on wound repair. The keywords of literature from the second retrieval formed 636 nodes and 7 clusters, that being #0 antibacterial, #1 mesenchymal stem cells, #2 cell migration, #3 wound repair, #4 exosomes, #5 negative pressure wound treatment, and #6 diabetic foot ulcer (Q=0.59, S=0.80). For the literature from the second retrieval, the main clusters from 2016 to 2023 were #0 antibacterial, #1 mesenchymal stem cells, and #4 exosomes, and the main clusters before 2015 were #2 cell migration and #3 wound repair. A total of 110 burst keywords (hereinafter referred to as burst words) were formed for the keywords of literature from the second retrieval, and the top 10 burst words in terms of intensity were mouse, gene expression, skin injury, epithelial cells, signaling pathways, biomaterials, exosomes, molecular docking, hydrogels, and macrophage polarization, with different start and end time periods. Among them, the high-intensity burst words from 2021 to 2023 were hydrogel (belonging to cluster #0 antibacterial), exosome (belonging to cluster #1 mesenchymal stem cells), molecular docking (belonging to cluster #0 antibacterial), and macrophage polarization (belonging to cluster #0 antibacterial).  Conclusions  In the future, the development of wound repair mechanism research will still be at a steady phase. The research hotspots in this field have shifted from growth factors and wound repair physiology to antibacterial and stem cells. Future research directions in this field may include using molecular docking technology and network pharmacology to screen drugs that promote wound repair and study their underlying mechanisms, the regulation of macrophage polarization by exosomes, and the mechanism by which hydrogels promote wound healing through antibacterial effects.

     

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    • References(34)
  • [1]
    BarrientosS, BremH, StojadinovicO, et al. Clinical application of growth factors and cytokines in wound healing[J]. Wound Repair Regen, 2014,22(5):569-578. DOI: 10.1111/wrr.12205.
    [2]
    NieC, YangD, XuJ, et al. Locally administered adipose-derived stem cells accelerate wound healing through differentiation and vasculogenesis[J]. Cell Transplant, 2011,20(2):205-216. DOI: 10.3727/096368910X520065.
    [3]
    WangM, XuX, LeiX, et al. Mesenchymal stem cell-based therapy for burn wound healing[J/OL]. Burns Trauma, 2021,9:tkab002[2024-01-18]. https://pubmed.ncbi.nlm.nih.gov/34212055/. DOI: 10.1093/burnst/tkab002.
    [4]
    YangX, MoW, ShiY, et al. Fumaria officinalis-loaded chitosan nanoparticles dispersed in an alginate hydrogel promote diabetic wounds healing by upregulating VEGF, TGF-β, and b-FGF genes: a preclinical investigation[J]. Heliyon, 2023,9(7):e17704. DOI: 10.1016/j.heliyon.2023.e17704.
    [5]
    陈瀚熙, 黄颖雯, 刘汶佶, 等. 国内外电烧伤研究现状与热点的可视化分析[J].中华烧伤与创面修复杂志,2023,39(10):977-984. DOI: 10.3760/cma.j.cn501225-20230511-00167.
    [6]
    KulkarniAB, HuhCG, BeckerD, et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death[J]. Proc Natl Acad Sci U S A, 1993, 90(2):770-774. DOI: 10.1073/pnas.90.2.770.
    [7]
    LiY, FanJ, ChenM, et al. Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration[J]. J Invest Dermatol, 2006,126(9):2096-2105. DOI: 10.1038/sj.jid.5700350.
    [8]
    ClarkDA, CokerR. Transforming growth factor-beta (TGF-beta)[J]. Int J Biochem Cell Biol, 1998,30(3):293-298. DOI: 10.1016/s1357-2725(97)00128-3.
    [9]
    AranyPR, FlandersKC, KobayashiT, et al. Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure[J]. Proc Natl Acad Sci U S A, 2006,103(24):9250-9255. DOI: 10.1073/pnas.0602473103.
    [10]
    SunJ, ZhaoH, ShenC, et al. Tideglusib promotes wound healing in aged skin by activating PI3K/Akt pathway[J]. Stem Cell Res Ther, 2022,13(1):269. DOI: 10.1186/s13287-022-02949-2.
    [11]
    CaronC, DeGeerJ, FournierP, et al. CdGAP/ARHGAP31, a Cdc42/Rac1 GTPase regulator, is critical for vascular development and VEGF-mediated angiogenesis[J]. Sci Rep, 2016,6:27485. DOI: 10.1038/srep27485.
    [12]
    NishidaT, KondoS, MaedaA, et al. CCN family 2/connective tissue growth factor (CCN2/CTGF) regulates the expression of Vegf through Hif-1alpha expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition[J]. Bone, 2009,44(1):24-31. DOI: 10.1016/j.bone.2008.08.125.
    [13]
    WijesooriyaLI, WaidyathilakeD. Antimicrobial properties of nonantibiotic agents for effective treatment of localized wound infections: a minireview[J]. Int J Low Extrem Wounds, 2022,21(3):207-218. DOI: 10.1177/1534734620939748.
    [14]
    BangS, JungUW, NohI. Synthesis and biocompatibility characterizations of in situ chondroitin sulfate-gelatin hydrogel for tissue engineering[J]. Tissue Eng Regen Med, 2018,15(1):25-35. DOI: 10.1007/s13770-017-0089-3.
    [15]
    MehataAK, SetiaA, Vikas, et al. Vitamin E TPGS-based nanomedicine, nanotheranostics, and targeted drug delivery: past, present, and future[J]. Pharmaceutics, 2023,15(3):722. DOI: 10.3390/pharmaceutics15030722.
    [16]
    LiuH, WangC, LiC, et al. A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing[J]. RSC Adv, 2018,8(14):7533-7549. DOI: 10.1039/c7ra13510f.
    [17]
    WengT, WangJ, YangM, et al. Nanomaterials for the delivery of bioactive factors to enhance angiogenesis of dermal substitutes during wound healing[J/OL]. Burns Trauma, 2022,10:tkab049[2024-01-18].https://pubmed.ncbi.nlm.nih.gov/36960274/. DOI: 10.1093/burnst/tkab049.
    [18]
    KolanthaiE, FuY, KumarU, et al. Nanoparticle mediated RNA delivery for wound healing[J]. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2022,14(2):e1741. DOI: 10.1002/wnan.1741.
    [19]
    LeeV, RompolasP. Corneal regeneration: insights in epithelial stem cell heterogeneity and dynamics[J]. Curr Opin Genet Dev, 2022,77:101981. DOI: 10.1016/j.gde.2022.101981.
    [20]
    ChoiYS, ZhangY, XuM, et al. Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis[J]. Cell Stem Cell, 2013,13(6):720-733. DOI: 10.1016/j.stem.2013.10.003.
    [21]
    ChengP, SunX, YinD, et al. Nanog down-regulates the Wnt signaling pathway via β-catenin phosphorylation during epidermal stem cell proliferation and differentiation[J]. Cell Biosci, 2015,5:5. DOI: 10.1186/2045-3701-5-5.
    [22]
    StamosJL, WeisWI. The β-catenin destruction complex[J]. Cold Spring Harb Perspect Biol, 2013,5(1):a007898. DOI: 10.1101/cshperspect.a007898.
    [23]
    BisevacJ, KattaK, PetrovskiG, et al. Wnt/β-catenin signaling activation induces differentiation in human limbal epithelial stem cells cultured ex vivo[J]. Biomedicines, 2023,11(7):1829. DOI: 10.3390/biomedicines11071829.
    [24]
    JorgeL, GómezAlvarez, PazziniJM, et al. Effects of canine adipose-derived mesenchymal stem cells on the epithelialization of rabbits' skin autograft (Oryctolagus cuniculus)[J].Pesquisa Veterinária Brasileira, 2020, 40(12):1018-1028.DOI: 10.1590/1678-5150-pvb-6543.
    [25]
    PitulescuME, SchmidtI, GiaimoBD, et al. Dll4 and Notch signalling couples sprouting angiogenesis and artery formation[J]. Nat Cell Biol, 2017,19(8):915-927. DOI: 10.1038/ncb3555.
    [26]
    KhanS, VillalobosMA, ChoronRL, et al. Fibroblast growth factor and vascular endothelial growth factor play a critical role in endotheliogenesis from human adipose-derived stem cells[J]. J Vasc Surg, 2017,65(5):1483-1492. DOI: 10.1016/j.jvs.2016.04.034.
    [27]
    YuF, WitmanN, YanD, et al. Human adipose-derived stem cells enriched with VEGF-modified mRNA promote angiogenesis and long-term graft survival in a fat graft transplantation model[J]. Stem Cell Res Ther, 2020,11(1):490. DOI: 10.1186/s13287-020-02008-8.
    [28]
    HuayllaniMT, Sarabia-EstradaR, RestrepoDJ, et al. Adipose-derived stem cells in wound healing of full-thickness skin defects: a review of the literature[J]. J Plast Surg Hand Surg, 2020,54(5):263-279. DOI: 10.1080/2000656X.2020.1767116.
    [29]
    ZhangW, BaiX, ZhaoB, et al. Cell-free therapy based on adipose tissue stem cell-derived exosomes promotes wound healing via the PI3K/Akt signaling pathway[J]. Exp Cell Res, 2018,370(2):333-342. DOI: 10.1016/j.yexcr.2018.06.035.
    [30]
    XiaJ, MinaminoS, KuwabaraK, et al. Stem cell secretome as a new booster for regenerative medicine[J]. Biosci Trends, 2019,13(4):299-307. DOI: 10.5582/bst.2019.01226.
    [31]
    ShangB, XuT, HuN, et al. Circ-Klhl8 overexpression increased the therapeutic effect of EPCs in diabetic wound healing via the miR-212-3p/SIRT5 axis[J]. J Diabetes Complications, 2021,35(11):108020. DOI: 10.1016/j.jdiacomp.2021.108020.
    [32]
    WangZ, FengC, LiuH, et al. Hypoxic pretreatment of adipose-derived stem cells accelerates diabetic wound healing via circ-Gcap14 and HIF-1α/VEGF mediated angiopoiesis[J]. Int J Stem Cells, 2021,14(4):447-454. DOI: 10.15283/ijsc21050.
    [33]
    LiY, ChengT, WanC, et al. circRNA_0084043 contributes to the progression of diabetic retinopathy via sponging miR-140-3p and inducing TGFA gene expression in retinal pigment epithelial cells[J]. Gene, 2020,747:144653. DOI: 10.1016/j.gene.2020.144653.
    [34]
    WangA, TomaMA, MaJ, et al. Circular RNA hsa_circ_0084443 is upregulated in diabetic foot ulcer and modulates keratinocyte migration and proliferation[J]. Adv Wound Care (New Rochelle), 2020,9(4):145-160. DOI: 10.1089/wound.2019.0956.
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