Coordinating tissue repair: molecular pathways controlling the function of harmful and repairing neutrophils

He Weifeng; Yan Lingfeng

doi:10.3760/cma.j.cn501225-20240306-00089

Volume 40 Issue 5

May 2024

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2024 > 40(5): 407-414

He WF,Yan LF.Coordinating tissue repair: molecular pathways controlling the function of harmful and repairing neutrophils[J].Chin J Burns Wounds,2024,40(5):407-414.DOI: 10.3760/cma.j.cn501225-20240306-00089.

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Coordinating tissue repair: molecular pathways controlling the function of harmful and repairing neutrophils

doi: 10.3760/cma.j.cn501225-20240306-00089

He Weifeng^,,
Yan Lingfeng

Institute of Burn Research, State Key Laboratory of Trauma and Chemical Poisoning, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing Key Laboratory for Wound Damage Repair and Regeneration, Chongqing 400038, China

Funds:

General Program of National Natural Science Foundation of China 31872742, 82172232

Military Medical Science and Technology Youth Training Program 20QNPY024

Special Project for Enhancing Science and Technology Innovation Ability of Army Medical University 2019XQY12

More Information

Corresponding author: He Weifeng, Email: whe761211@hotmail.com
Received Date: 2024-03-06

Abstract

Abstract

Neutrophils are the most abundant circulating white blood cells and play an indispensable role as first responders of damaged tissue and infected sites in the early inflammatory response of healing. Neutrophils provide immediate host defense by engulfing and destroying pathogens, releasing cytotoxic enzymes and metabolites, and spreading inflammatory networks. However, if left uncontrolled, these defense mechanisms can cause significant collateral damage. Focusing on the triggers of harmful neutrophil inflammation and immunomodulatory deficits, as well as grasping the specific drivers of harmful inflammation, is of great significance for recalibrating inflammation to promote endogenous tissue repair. This article, starting from the causes of neutrophil inflammation imbalance, elaborated the main mechanism of neutrophil-mediated tissue injury and related pathological manifestations, and highlighted the therapeutic targets with promising applications.
- Wound healing,
- Immunity,
- Inflammation,
- Neutrophils,
- Molecular pathways

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Coordinating tissue repair: molecular pathways controlling the function of harmful and repairing neutrophils

doi: 10.3760/cma.j.cn501225-20240306-00089

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Coordinating tissue repair: molecular pathways controlling the function of harmful and repairing neutrophils

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