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Volume 41 Issue 9
Sep.  2025
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2025  >  41(9): 905-910
Wang XL,Gao SY,Wei ZR.Research advances on the application of fibroblasts and their derivatives in the treatment of diabetic foot ulcers[J].Chin J Burns Wounds,2025,41(9):905-910.DOI: 10.3760/cma.j.cn501225-20241204-00475.
Citation: Wang XL,Gao SY,Wei ZR.Research advances on the application of fibroblasts and their derivatives in the treatment of diabetic foot ulcers[J].Chin J Burns Wounds,2025,41(9):905-910.DOI: 10.3760/cma.j.cn501225-20241204-00475.
shu

Research advances on the application of fibroblasts and their derivatives in the treatment of diabetic foot ulcers

doi: 10.3760/cma.j.cn501225-20241204-00475

  • Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China

Funds:

Regional Science Foundation Project of National Natural Science Foundation of China 82360445

Provincial and Ministry Collaborative Innovation Center Project 2020-39

Scientific Research and Talent Training Fund of Kweichow Moutai Hospital mtyk2022-13

Growth Factor Rejuvenation Plan of Shanghai Wang Zhengguo Trauma Medicine Development Foundation SZYZ-TR-05

Science and Technology Foundation of Health Commission of Guizhou Province of China gzwkj2024-155

More Information
  • Corresponding author: Wei Zairong, Email: zairongwei@163.com
  • Received Date: 2024-12-04
    Available Online: 2025-09-19
    Abstract
  • Diabetic foot ulcer (DFU) is one of the serious complications of diabetes mellitus, which is characterized by susceptibility to infection, difficult to cure, and easy to relapse. At present, the treatment methods for DFUs include standard nursing care, surgical treatment, and medication, but the clinical efficacy is suboptimal. Fibroblasts (Fbs), as one of the key cells for wound healing, can not only secrete fibronectin and collagen to construct scaffolds for cell migration, proliferation, and colonization of keratinocytes and epithelial cells, but also secrete inflammatory factors, growth factors, and cytokines to reverse the chronic inflammation of DFUs, promote cell proliferation, and improve the wound microenvironment. It is one of the cell types currently used in DFU wound treatment. This article reviews the application of Fbs and their derivatives in DFU treatment from the perspective of Fbs, in order to provide a reference for DFU treatment.

     

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