Research on the pathogenesis and treatment of diabetic foot ulcer wounds

Wang Xin; Wang Yinyu; Qi Jianwu

doi:10.3760/cma.j.cn501225-20250124-00039

Volume 41 Issue 10

Oct. 2025

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2025 > 41(10): 928-936

Wang X,Wang YY,Qi JW.Research on the pathogenesis and treatment of diabetic foot ulcer wounds[J].Chin J Burns Wounds,2025,41(10):928-936.DOI: 10.3760/cma.j.cn501225-20250124-00039.

Citation:

Wang X,Wang YY,Qi JW.Research on the pathogenesis and treatment of diabetic foot ulcer wounds[J].Chin J Burns Wounds,2025,41(10):928-936.DOI: 10.3760/cma.j.cn501225-20250124-00039.

Citation:

Wang X,Wang YY,Qi JW.Research on the pathogenesis and treatment of diabetic foot ulcer wounds[J].Chin J Burns Wounds,2025,41(10):928-936.DOI: 10.3760/cma.j.cn501225-20250124-00039.

PDF( 1236 KB)

Research on the pathogenesis and treatment of diabetic foot ulcer wounds

doi: 10.3760/cma.j.cn501225-20250124-00039

Department of Hand Surgery, Ningbo No.6 Hospital, Ningbo 315040, China

Funds:

Ningbo Municipal High-Level Medical and Health Talent Team Major Breakthrough Project 2022020506

More Information

Corresponding author: Wang Xin, Email: nblyswk@163.com
Received Date: 2025-01-24

Abstract

Abstract

With the improvement of living standards and dietary conditions of civilians, the incidence of diabetes mellitus is also increasing gradually. Diabetic foot ulcers (DFU), a serious complication of diabetes mellitus, are associated with high rates of amputation and mortality, placing huge psychological and economic burdens on patients. The complex pathogenesis and difficult-to-heal wounds pose significant challenges to the prognosis of DFU patients. This article will elaborate on the pathogenesis of DFU wounds by integrating the latest research progress at home and abroad and summarize the current treatment schemes for different types of DFU wounds, aiming to provide guidance for clinical treatment of DFU wounds.
- Diabetic foot,
- Foot ulcer,
- Pathogenesis,
- Wound repair,
- Treatment progress

FullText(HTML)

References(90)

References

[1]	SeshadriH,KarthikeyanV,RudrakumarM,et al.Out-of-pocket expenditure among patients with diabetic foot ulcer in a tertiary care hospital of south India: a cross-sectional study[J].Int Wound J,2024,21(4):e14552.DOI: 10.1111/iwj.14552.
[2]	AkkusG,SertM.Diabetic foot ulcers: a devastating complication of diabetes mellitus continues non-stop in spite of new medical treatment modalities[J].World J Diabetes,2022,13(12):1106-1121.DOI: 10.4239/wjd.v13.i12.1106.
[3]	DengL,WangG,JuS.Correlation between inflammatory factors, autophagy protein levels, and infection in granulation tissue of diabetic foot ulcer[J].Immun Inflamm Dis,2024,12(4):e1233.DOI: 10.1002/iid3.1233.
[4]	ZhengH,NaH,YaoJ,et al.16S rRNA seq-identified Corynebacterium promotes pyroptosis to aggravate diabetic foot ulcer[J].BMC Infect Dis,2024,24(1):366.DOI: 10.1186/s12879-024-09235-x.
[5]	ShenQ,LiB,ChenH,et al.Podiatrist intervention could reduce the incidence of foot ulcers in patients with diabetes: a hospital survey in China[J].J Wound Care,2024,33(Suppl 4):S25-S32.DOI: 10.12968/jowc.2024.33.Sup4.S25.
[6]	MairghaniM,PattonD,SorensenJ,et al.Health-related quality of life in patients with diabetic foot ulcers in the Arab world: a systematic review[J].J Wound Care,2024,33(4):253-261.DOI: 10.12968/jowc.2024.33.4.253.
[7]	WangY,WangC,ZhengL.Bibliometric analysis of systematic review and meta-analysis on diabetic foot ulcer[J].Heliyon,2024,10(6):e27534.DOI: 10.1016/j.heliyon.2024.e27534.
[8]	ZaheerH,ZaheerMH.Characteristics and outcomes of diabetic foot ulcers treated with surgical debridement and standardized wound care[J].Int Wound J,2024,21(7):e70007.DOI: 10.1111/iwj.70007.
[9]	CarusoP,ScappaticcioL,GicchinoM,et al.Short-term glucose variability as a determinant of the healing rate of diabetic foot ulcer: a retrospective study[J].Diabetes Metab Syndr,2024,18(3):102990.DOI: 10.1016/j.dsx.2024.102990.
[10]	McDermottK,FangM,BoultonAJM,et al.Etiology, epidemiology, and disparities in the burden of diabetic foot ulcers[J].Diabetes Care,2023,46(1):209-221.DOI: 10.2337/dci22-0043.
[11]	DengH,LiB,ShenQ,et al.Mechanisms of diabetic foot ulceration: a review[J].J Diabetes,2023,15(4):299-312.DOI: 10.1111/1753-0407.13372.
[12]	BrownriggJR,SchaperNC,HinchliffeRJ.Diagnosis and assessment of peripheral arterial disease in the diabetic foot[J].Diabet Med,2015,32(6):738-747.DOI: 10.1111/dme.12749.
[13]	HoweEE,ApollinaroM,BentLR.Mechanoreceptor sensory feedback is impaired by pressure induced cutaneous ischemia on the human foot sole and can predict cutaneous microvascular reactivity[J].Front Neurosci,2024,18:1329832.DOI: 10.3389/fnins.2024.1329832.
[14]	WangX,LiR,ZhaoH.Enhancing angiogenesis: innovative drug delivery systems to facilitate diabetic wound healing[J].Biomed Pharmacother,2024,170:116035.DOI: 10.1016/j.biopha.2023.116035.
[15]	龙露瑶,陈燕微,邓如非,等.延迟腓肠神经营养血管皮瓣在糖尿病足溃疡中的应用与研究进展[J].中华烧伤与创面修复杂志,2024,40(3):296-300.DOI: 10.3760/cma.j.cn501225-20231102-00173.
[16]	OkurKT,OzanF,KahramanM,et al.Assessment of the risk factors determining the prognosis of major and minor limb amputations in patients with diabetic foot ulcers[J].Adv Clin Exp Med,2024,33(1):21-30.DOI: 10.17219/acem/163240.
[17]	StrandN,AndersonMA,AttantiS,et al.Diabetic neuropathy: pathophysiology review[J].Curr Pain Headache Rep,2024,28(6):481-487.DOI: 10.1007/s11916-024-01243-5.
[18]	BraggS,MarrisonST,HaleyS.Diabetic peripheral neuropathy: prevention and treatment[J].Am Fam Physician,2024,109(3):226-232.
[19]	BhattiJS,SehrawatA,MishraJ,et al.Oxidative stress in the pathophysiology of type 2 diabetes and related complications: current therapeutics strategies and future perspectives[J].Free Radic Biol Med,2022,184:114-134.DOI: 10.1016/j.freeradbiomed.2022.03.019.
[20]	DewanjeeS,DasS,DasAK,et al.Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets[J].Eur J Pharmacol,2018,833:472-523.DOI: 10.1016/j.ejphar.2018.06.034.
[21]	LunaR,Talanki ManjunathaR,BolluB,et al.A comprehensive review of neuronal changes in diabetics[J].Cureus,2021,13(10):e19142.DOI: 10.7759/cureus.19142.
[22]	DengJY,WuXQ,HeWJ,et al.Targeting DNA methylation and demethylation in diabetic foot ulcers[J].J Adv Res,2023,54:119-131.DOI: 10.1016/j.jare.2023.01.009.
[23]	JavanianM,BararyM,ShokriM,et al.Risk factors for amputation in diabetic foot ulcers: a retrospective analysis[J].Int Wound J,2024,21(9):e70037.DOI: 10.1111/iwj.70037.
[24]	LavigneJP,SottoA,Dunyach-RemyC,et al. New molecular techniques to study the skin microbiota of diabetic foot ulcers[J].Adv Wound Care (New Rochelle),2015,4(1):38-49.DOI: 10.1089/wound.2014.0532.
[25]	GonçalvesJ,GuimarãesAR,FerreiraHU,et al.Microbiological characterization of neuropathic diabetic foot infection: a retrospective study at a Portuguese tertiary hospital[J].BMC Infect Dis,2024,24(1):791.DOI: 10.1186/s12879-024-09677-3.
[26]	BurgessJL,WyantWA,Abdo AbujamraB,et al.Diabetic wound-healing science[J].Medicina (Kaunas),2021,57(10):1072.DOI: 10.3390/medicina57101072.
[27]	PatelBK,PatelKH,HuangRY,et al.The gut-skin microbiota axis and its role in diabetic wound healing-a review based on current literature[J].Int J Mol Sci,2022,23(4):2375.DOI: 10.3390/ijms23042375.
[28]	DarwitzBP,GenitoCJ,ThurlowLR.Triple threat: how diabetes results in worsened bacterial infections[J].Infect Immun,2024,92(9):e0050923.DOI: 10.1128/iai.00509-23.
[29]	MaY.Role of neutrophils in cardiac injury and repair following myocardial infarction[J].Cells,2021,10(7):1676.DOI: 10.3390/cells10071676.
[30]	中华医学会糖尿病学分会,中华医学会感染病学分会,中华医学会组织修复与再生分会.中国糖尿病足防治指南(2019版)(Ⅳ)[J].中华糖尿病杂志,2019,11(5):316-327.DOI: 10.3760/cma.j.issn.1674-5809.2019.05.003.
[31]	赵晨旭,周慧敏.《中国糖尿病足诊治指南》解读[J].中国临床医生杂志,2021,49(12):1405-1408.DOI: 10.3969/j.issn.2095-8552.2021.12.007.
[32]	中华医学会糖尿病学分会,中华医学会感染病学分会,中华医学会组织修复与再生分会.中国糖尿病足防治指南(2019版)(Ⅰ)[J].中华糖尿病杂志,2019,11(2):92-108.DOI: 10.3760/cma.j.issn.1674-5809.2019.02.004.
[33]	李晓庆,谢书睿,黄天一.舒脉胶囊治疗早期糖尿病足神经性溃疡的临床疗效观察[J].中国中西医结合外科杂志,2024,30(1):9-12.DOI: 10.3969/j.issn.1007-6948.2024.01.002.
[34]	鹿亮,孙怡宁,马祖长.糖尿病足底压力研究进展[J].中华骨与关节外科杂志,2024,17(6):566-572.DOI: 10.3969/j.issn.2095-9958.2024.06.11.
[35]	江平,梁王班,陈可锋.VSD治疗神经缺血性糖尿病足溃疡的效果探讨[J].中国现代药物应用,2020,14(6):27-29.DOI: 10.14164/j.cnki.cn11-5581/r.2020.06.011.
[36]	国际血管联盟中国分会糖尿病足专业委员会.糖尿病足诊治指南[J].介入放射学杂志,2013,22(9):705-708.DOI: 10.3969/j.issn.1008-794X.2013.09.001.
[37]	TorabiE,OmidvariS,AzimzadehZ,et al.Exploring photobiomodulation therapy and regenerative medicine for diabetic foot ulcers: pathogenesis and multidisciplinary treatment approach[J].J Lasers Med Sci,2024,15:e18.DOI: 10.34172/jlms.2024.18.
[38]	OgbeideOA,OkelekeSI,OkorieJC,et al.Evolving trends in the management of diabetic foot ulcers: a narrative review[J].Cureus,2024,16(7):e65095.DOI: 10.7759/cureus.65095.
[39]	ShiL,JiangZ,LiJ,et al.Metformin improves burn wound healing by modulating microenvironmental fibroblasts and macrophages[J].Cells,2022,11(24):4094.DOI: 10.3390/cells11244094.
[40]	HanX,TaoY,DengY,et al.Metformin accelerates wound healing in type 2 diabetic db/db mice[J].Mol Med Rep,2017,16(6):8691-8698.DOI: 10.3892/mmr.2017.7707.
[41]	BasiriR,SpicerM,LevensonC,et al.Improving dietary intake of essential nutrients can ameliorate inflammation in patients with diabetic foot ulcers[J].Nutrients,2022,14(12):2393.DOI: 10.3390/nu14122393.
[42]	JiangP,LiQ,LuoY,et al.Current status and progress in research on dressing management for diabetic foot ulcer[J].Front Endocrinol (Lausanne),2023,14:1221705.DOI: 10.3389/fendo.2023.1221705.
[43]	中华医学会内分泌学分会,中国内分泌代谢病专科联盟.糖尿病足溃疡创面治疗专家共识(2024)[J].中华内分泌代谢杂志,2024,40(7):565-569.DOI: 10.3760/cma.j.cn311282-20240625-00281.
[44]	GallagherKA,MillsJL,ArmstrongDG,et al.Current status and principles for the treatment and prevention of diabetic foot ulcers in the cardiovascular patient population: a scientific statement from the American Heart Association[J].Circulation,2024,149(4):e232-e253.DOI: 10.1161/CIR.0000000000001192.
[45]	AldanaPC,KhachemouneA.Diabetic foot ulcers: appraising standard of care and reviewing new trends in management[J].Am J Clin Dermatol,2020,21(2):255-264.DOI: 10.1007/s40257-019-00495-x.
[46]	RingblomA,IvoryJ,AdlerberthI,et al.Wound cleansing solutions versus normal saline in the treatment of diabetic foot ulcers - a systematic review[J].J Tissue Viability,2024,33(4):591-597.DOI: 10.1016/j.jtv.2024.08.010.
[47]	JaberD,YounesN,KhalilE,et al.Effect of diluted Dakin's solution versus standard care on diabetic foot ulcer management: a randomized controlled trial[J].J Am Podiatr Med Assoc,2022,112(1):20-213.DOI: 10.7547/20-213.
[48]	ZiaianB,KhezriS,AmirianA,et al.Hypertonic saline solution 5% as an effective cost-beneficial alternative to normal saline for wound healing in patients with diabetic lower-extremity ulcers: a randomized controlled trial[J].J Diabetes Metab Disord,2022,22(1):479-485.DOI: 10.1007/s40200-022-01167-0.
[49]	YadavJP,SinghAK,GrishinaM,et al.Insights into the mechanisms of diabetic wounds: pathophysiology, molecular targets, and treatment strategies through conventional and alternative therapies[J].Inflammopharmacology,2024,32(1):149-228.DOI: 10.1007/s10787-023-01407-6.
[50]	HosseiniRS,HasanpourK,KhoshnevisM,et al.Therapeutic effect of silver nanoparticles in the management of diabetic ulcers: a systematic review and meta-analysis on RCTs[J/OL].Int J Low Extrem Wounds,2024:15347346241241836(2024-03-27)[2025-01-24].https://pubmed.ncbi.nlm.nih.gov/38544426/.DOI:10.1177/15347346241241836.[published online ahead of print].
[51]	ChenC,OuQ,ChenK,et al.Foam dressing and micropower vacuum dressing promote diabetic foot ulcer wound healing by activating the PI3K/AKT/mTOR pathway in rats[J].J Biomater Appl,2024,39(1):40-47.DOI: 10.1177/08853282241248780.
[52]	KeykhaeeM,RahimifardM,NajafiA,et al.Corrigendum to "Alginate/gum arabic-based biomimetic hydrogel enriched with immobilized nerve growth factor and carnosine improves diabetic wound regeneration" [Carbohydrate Polymers 321, (2023), 121179][J].Carbohydr Polym,2025,351:123139.DOI: 10.1016/j.carbpol.2024.123139.
[53]	LiZ,QianC,ZhengX,et al.Collagen/chitosan/genipin hydrogel loaded with phycocyanin nanoparticles and ND-336 for diabetic wound healing[J].Int J Biol Macromol,2024,266(Pt 1):131220.DOI: 10.1016/j.ijbiomac.2024.131220.
[54]	SenP,DemirdalT,EmirB.Meta-analysis of risk factors for amputation in diabetic foot infections[J].Diabetes Metab Res Rev,2019,35(7):e3165.DOI: 10.1002/dmrr.3165.
[55]	RaymanG,VasP,DhatariyaK,et al.Guidelines on use of interventions to enhance healing of chronic foot ulcers in diabetes (IWGDF 2019 update)[J].Diabetes Metab Res Rev,2020,36Suppl 1:e3283.DOI: 10.1002/dmrr.3283.
[56]	LiuE,HuX,ZhangW,et al.Efficacy and safety of ultrasound-assisted wound debridement in the treatment of diabetic foot ulcers: a systematic review and meta-analysis of 11 randomized controlled trials[J].Front Endocrinol (Lausanne),2024,15:1393251.DOI: 10.3389/fendo.2024.1393251.
[57]	Lázaro-MartínezJL,Álvaro-AfonsoFJ,Sevillano-FernándezD,et al.Cellular proliferation, dermal repair, and microbiological effectiveness of ultrasound-assisted wound debridement (UAW) versus standard wound treatment in complicated diabetic foot ulcers (DFU): an open-label randomized controlled trial[J].J Clin Med,2020,9(12):4032.DOI: 10.3390/jcm9124032.
[58]	RasouliM,GoliR,NokashtiHH.Surgical debridement and maggot debridement therapy can survive patient with diabetic foot ulcer after foot trauma: a case report[J].Int J Surg Case Rep,2024,121:109990.DOI: 10.1016/j.ijscr.2024.109990.
[59]	TombulturkFK,Kanigur-SultuybekG.A molecular approach to maggot debridement therapy with Lucilia sericata and its excretions/secretions in wound healing[J].Wound Repair Regen,2021,29(6):1051-1061.DOI: 10.1111/wrr.12961.
[60]	BabiarczykB,TobiczykJ.Patient perceptions and experiences with maggot debridement therapy for managing chronic wounds[J].J Wound Ostomy Continence Nurs,2024,51(3):180-184.DOI: 10.1097/WON.0000000000001067.
[61]	LiL,ZhangG,SunY.Antibiotic bone cement accelerates diabetic foot wound healing-elucidating the role of ROCK1 protein expression[J].Int Wound J,2024,21(6):e14945.DOI: 10.1111/iwj.14945.
[62]	DongT,HuangQ,SunZ.Antibiotic-laden bone cement for diabetic foot infected wounds: a systematic review and meta-analysis[J].Front Endocrinol (Lausanne),2023,14:1134318.DOI: 10.3389/fendo.2023.1134318.
[63]	赵雅玫,冯磊,谢斌,等.抗生素骨水泥治疗糖尿病足溃疡疗效的Meta分析[J].中华糖尿病杂志,2024,16(7):790-798.DOI: 10.3760/cma.j.cn115791-20230927-00201.
[64]	ChenH,YaoL,ZhouY,et al.Evaluation of antibiotic-loaded bone cement in treatment of infected diabetic foot: systematic review and meta-analysis[J].Diabetes Metab Res Rev,2024,40(8):e70002.DOI: 10.1002/dmrr.70002.
[65]	DaiJ,ZhouY,MeiS,et al.Application of antibiotic bone cement in the treatment of infected diabetic foot ulcers in type 2 diabetes[J].BMC Musculoskelet Disord,2023,24(1):135.DOI: 10.1186/s12891-023-06244-w.
[66]	赵晨兵,张会峰.载抗生素骨水泥治疗糖尿病足感染创面的研究进展[J].中华糖尿病杂志,2022,14(7):724-729.DOI: 10.3760/cma.j.cn115791-20211213-00660.
[67]	赵晨兵,张会峰,刘琳琳,等.载抗生素骨水泥治疗高龄糖尿病足患者2例[J].中华糖尿病杂志,2022,14(7):711-716.DOI: 10.3760/cma.j.cn115791-20211214-00661.
[68]	曹涛,计鹏,张智,等.抗生素骨水泥治疗糖尿病足溃疡的前瞻性随机对照研究[J].中华烧伤与创面修复杂志,2023,39(4):311-318.DOI: 10.3760/cma.j.cn501225-20221111-00485.
[69]	WangK,WangY,ShiW,et al.Diagnosis and treatment of diabetic foot ulcer complicated with lower extremity vasculopathy: consensus recommendation from the Chinese Medical Association (CMA), Chinese Medical Doctor Association (CMDA)[J].Diabetes Metab Res Rev,2024,40(3):e3776.DOI: 10.1002/dmrr.3776.
[70]	HinchliffeRJ,BrownriggJR,AndrosG,et al.Effectiveness of revascularization of the ulcerated foot in patients with diabetes and peripheral artery disease: a systematic review[J].Diabetes Metab Res Rev,2016,32Suppl 1:136-144.DOI: 10.1002/dmrr.2705.
[71]	MeloniM,MorosettiD,GiuratoL,et al.Foot revascularization avoids major amputation in persons with diabetes and ischaemic foot ulcers[J].J Clin Med,2021,10(17):3977.DOI: 10.3390/jcm10173977.
[72]	常树森,杨尉,宋荷花,等.胫骨横向骨搬移技术联合改良神经松解术治疗糖尿病足溃疡[J].中国修复重建外科杂志,2023,37(11):1410-1417.DOI: 10.7507/1002-1892.202306016.
[73]	HouX,GuoP,CaiF,et al.Angiosome-guided endovascular revascularization for treatment of diabetic foot ulcers with peripheral artery disease[J].Ann Vasc Surg,2022,86:242-250.DOI: 10.1016/j.avsg.2022.02.012.
[74]	ChuterV,SchaperN,MillsJ,et al.Effectiveness of revascularisation for the ulcerated foot in patients with diabetes and peripheral artery disease: a systematic review[J].Diabetes Metab Res Rev,2024,40(3):e3700.DOI: 10.1002/dmrr.3700.
[75]	ClaytonZE,TanRP,MiravetMM,et al.Induced pluripotent stem cell-derived endothelial cells promote angiogenesis and accelerate wound closure in a murine excisional wound healing model[J].Biosci Rep,2018,38(4):BSR20180563.DOI: 10.1042/BSR20180563.
[76]	BuchadeS,DesaiS,BhondeR,et al.Stem cells: a golden therapy for diabetic wounds[J].Curr Diabetes Rev,2021,17(2):156-160.DOI: 10.2174/1573399816666200716200450.
[77]	KedarDJ,SuhHS,ParkCJ,et al.Soft tissue reconstruction after revascularization[J].Int J Low Extrem Wounds,2024,23(1):27-32.DOI: 10.1177/15347346231210144.
[78]	HongJP,OhTS.An algorithm for limb salvage for diabetic foot ulcers[J].Clin Plast Surg,2012,39(3):341-352.DOI: 10.1016/j.cps.2012.05.004.
[79]	刘欣,黄广涛,吴军.游离皮瓣在糖尿病足溃疡患者保肢治疗中的应用研究进展[J].中华烧伤与创面修复杂志,2024,40(10):985-990.DOI: 10.3760/cma.j.cn501225-20240130-00041.
[80]	BhatS,ChiaB,BarryIP,et al.Free tissue transfer in diabetic foot ulcers: a systematic review and meta-analysis[J].Eur J Vasc Endovasc Surg,2023,66(5):670-677.DOI: 10.1016/j.ejvs.2023.07.031.
[81]	赵建军,谢振军,赵国红,等.多学科团队协作模式下游离股前外侧穿支皮瓣修复糖尿病足溃疡的临床效果[J].中华烧伤与创面修复杂志,2024,40(8):756-761.DOI: 10.3760/cma.j.cn501225-20231107-00184.
[82]	简扬,魏在荣,陈伟,等.游离皮瓣在糖尿病足溃疡修复中的应用研究进展[J].中华烧伤与创面修复杂志,2023,39(4):376-380.DOI: 10.3760/cma.j.cn501225-20221216-00539.
[83]	Fitzgerald O'ConnorEJ,VeselyM,HoltPJ,et al.A systematic review of free tissue transfer in the management of non-traumatic lower extremity wounds in patients with diabetes[J].Eur J Vasc Endovasc Surg,2011,41(3):391-399.DOI: 10.1016/j.ejvs.2010.11.013.
[84]	赵明月,杨顺,涂希玲,等.富血小板血浆联合静电纺丝纳米支架在骨及软组织修复中的应用[J].中国组织工程研究,2023,27(34):5554-5560.
[85]	TcheroH,HerlinC,BekaraF,et al.Failure rates of artificial dermis products in treatment of diabetic foot ulcer: a systematic review and network meta-analysis[J].Wound Repair Regen,2017,25(4):691-696.DOI: 10.1111/wrr.12554.
[86]	OleyMH,OleyMC,KepelBJ,et al.Hyperbaric oxygen therapy for diabetic foot ulcers based on Wagner grading: a systematic review and meta-analysis[J].Plast Reconstr Surg Glob Open,2024,12(3):e5692.DOI: 10.1097/GOX.0000000000005692.
[87]	DalmedicoMM,do Rocio FedaltoA,MartinsWA,et al.Effectiveness of negative pressure wound therapy in treating diabetic foot ulcers: a systematic review and meta-analysis of randomized controlled trials[J].Wounds,2024,36(8):281-289.DOI: 10.25270/wnds/23140.
[88]	XuB,SongX,WengY.A multidisciplinary team approach for diabetic foot ulcer: a case study[J].Adv Skin Wound Care,2023,36(4):1-4.DOI: 10.1097/01.ASW.0000920512.88426.90.
[89]	MacfarlaneSM,ZhaoSX,LafrenzJO,et al.Effect of a multidisciplinary team approach on the management of diabetic foot ulcers on the Central Coast: a review of the Gosford Hospital High-Risk Foot Clinic[J].Int Wound J,2024,21(2):e14570.DOI: 10.1111/iwj.14570.
[90]	刘丽,方晓霞,张坤,等.多学科管理联合60秒糖尿病足风险筛查在糖尿病足患者中的应用[J].中华现代护理杂志,2024,30(27):3673-3677.DOI: 10.3760/cma.j.cn115682-20231228-02866.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1)

Get Citation

PDF

XML

Article Metrics

Article views (237) PDF downloads(48)

Research on the pathogenesis and treatment of diabetic foot ulcer wounds

doi: 10.3760/cma.j.cn501225-20250124-00039

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Research on the pathogenesis and treatment of diabetic foot ulcer wounds

doi: 10.3760/cma.j.cn501225-20250124-00039

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content