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Volume 42 Issue 5
May  2026
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2026  >  42(5): 496-502
Shan B,Guo ZA,Ma XP,et al.Research progress on the mechanism of mitochondrial dynamics in diabetic foot ulcers and its related intervention strategies[J].Chin J Burns Wounds,2026,42(5):496-502.DOI: 10.3760/cma.j.cn501225-20250304-00114.
Citation: Shan B,Guo ZA,Ma XP,et al.Research progress on the mechanism of mitochondrial dynamics in diabetic foot ulcers and its related intervention strategies[J].Chin J Burns Wounds,2026,42(5):496-502.DOI: 10.3760/cma.j.cn501225-20250304-00114.
shu

Research progress on the mechanism of mitochondrial dynamics in diabetic foot ulcers and its related intervention strategies

doi: 10.3760/cma.j.cn501225-20250304-00114
  • 1.

    Department of Joint Surgery, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

  • 2.

    School of Traditional Chinese and Western Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

Funds:

Regional Science Fund program of National Natural Science Foundation of China 82560950

General Program of Gansu Provincial Joint Funds 24JRRA881

Lanzhou Science and Technology Plan Project 2023-ZD-210

Science and Technology Plan Project of Chengguan District of Lanzhou City 2022SHFZ0021

More Information
  • Corresponding author: Zeng Zhaoyang, Email: 523645455@qq.com
  • Received Date: 2025-03-04
    Available Online: 2026-05-22
    Abstract
  • Diabetic foot ulcer (DFU) is a common and serious chronic complication in patients with diabetes, characterized by high recurrence rates, risks of disability and mortality, which imposes a heavy burden on individual health and the social healthcare system. Mitochondrial dynamics refer to the dynamic balance between mitochondrial fission and fusion that maintains cellular energy metabolism and homeostasis. However, in the pathological environment of diabetes, hyperglycemia and oxidative stress disrupt this balance, leading to mitochondrial dysfunction and further exacerbating the inflammatory response and tissue damage in DFU. In recent years, intervention strategies targeting mitochondrial dynamics have been considered a potential therapeutic approach to alleviate DFU symptoms and promote wound healing. Based on the latest domestic and international research, this article reviews the progress of research on mitochondrial dynamics in DFU, with a focus on exploring its core mechanisms and regulatory factors in the pathological process of DFU, and summarizes the current main intervention strategies. Through systematic analysis, this article aims to deepen the understanding of the mechanisms underlying mitochondrial dynamics in DFU and to provide new ideas for targeted therapy in clinical practice.

     

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