Volume 41 Issue 10
Oct.  2025
Turn off MathJax
Article Contents
Lyu GZ,Zhao P.Researches and clinical translation of smart dressings[J].Chin J Burns Wounds,2025,41(10):911-917.DOI: 10.3760/cma.j.cn501225-20250807-00348.
Citation: Lyu GZ,Zhao P.Researches and clinical translation of smart dressings[J].Chin J Burns Wounds,2025,41(10):911-917.DOI: 10.3760/cma.j.cn501225-20250807-00348.

Researches and clinical translation of smart dressings

doi: 10.3760/cma.j.cn501225-20250807-00348
Funds:

National Key Research and Development Program of China 2022YFC3006200

Clinical Frontier Technology Program of Social Development of Science and Technology Agency of Jiangsu Province of China BE2018626

More Information
  • The research and application of smart dressings are a focal point in fields such as burn and wound repair. Breakthroughs in miniaturized electronic components, fiber optics and wireless communication technologies, and flexible circuit, and the research and development of novel biomaterials have laid foundation for the development and application of smart dressings. Real-time, rapid-response, multifunctional smart dressings are emerging, showing great potential in aspects such as early detection of wound infections, assessment of inflammatory responses, monitoring changes in wound characteristics, and estimating wound healing direction and duration. They also provide opportunities for precise and controlled local drug delivery to wounds and microcurrent stimulation therapy. This article introduces the classification, research progress, and clinical trials of smart dressings, and analyzes the functions, advantages, and limitations of sensor-based smart dressings by categorizing them into active and passive types. Additionally, this article introduces three types of broadly defined, non-sensor-based smart dressings that can identify changes in specific wound parameters and respond accordingly such as changing color, releasing drugs, or exhibiting microcurrent. Based on this, the article also provides an outlook on the future of smart dressings.

     

  • loading
  • [1]
    付小兵.再论“战时治烧伤,平时治创面”的学术理念及其实践[J].中华烧伤与创面修复杂志,2025,41(7):609-612.DOI: 10.3760/cma.j.cn501225-20250515-00227.
    [2]
    荀浩怡,苏小薇,胡方超,等.改良型富血小板纤维蛋白/壳聚糖温敏水凝胶对糖尿病大鼠全层皮肤缺损创面愈合的影响[J].中华烧伤与创面修复杂志,2024,40(5):451-460.DOI: 10.3760/cma.j.cn501225-20231020-00127.
    [3]
    DongR, GuoB. Smart wound dressings for wound healing[J]. Nano Today, 2021, 41: 101290.
    [4]
    Rezvani GhomiE, NiaziM, RamakrishnaS. The evolution of wound dressings: from traditional to smart dressings[J]. Polym Adv Technol, 2023, 34(2): 520-530.
    [5]
    BishopA.Wound assessment and dressing selection: an overview[J].Br J Nurs,2021,30(5):S12-S20.DOI: 10.12968/bjon.2021.30.5.S12.
    [6]
    石明生, 梁晓炀, 张瑞, 等. 透明质酸生物胶的性能及其对小鼠烧伤感染性创面愈合的影响[J]. 中华烧伤与创面修复杂志, 2025, 41(10): 949-957. DOI: 10.3760/cma.j.cn501225-20250422-00186.
    [7]
    李玉骞, 张婷婷, 邹桂连, 等. 线粒体移植对糖尿病大鼠全层皮肤缺损的影响[J]. 中华烧伤与创面修复杂志, 2025, 41(10): 937-948. DOI: 10.3760/cma.j.cn501225-20250721-00315.
    [8]
    WangC,FanK,Shirzaei SaniE,et al.A microfluidic wearable device for wound exudate management and analysis in human chronic wounds[J].Sci Transl Med,2025,17(795):eadt0882.DOI: 10.1126/scitranslmed.adt0882.
    [9]
    潘泽平,石云龙,袁志强,等.负载锌离子的复合水凝胶对糖尿病小鼠全层皮肤缺损感染创面的作用及机制[J].中华烧伤与创面修复杂志,2024,40(9):866-875.DOI: 10.3760/cma.j.cn501225-20231120-00200.
    [10]
    MostafaluPAmugothuSTamayolAet alSmart flexible wound dressing with wireless drug deliveryProceedings of the 2015 IEEE biomedical circuits and systems conferenceIEEE2015https://ieeexplore.ieee.org/document/7348391DOI:10.1109/BioCAS.2015.7348391

    MostafaluP, AmugothuS, TamayolA, et al. Smart flexible wound dressing with wireless drug delivery[C/OL].Proceedings of the 2015 IEEE biomedical circuits and systems conference, IEEE, 2015. https://ieeexplore.ieee.org/document/7348391. DOI:10.1109/BioCAS.2015.7348391.

    [11]
    BrownMS,AshleyB,KohA.Wearable technology for chronic wound monitoring: current dressings, advancements, and future prospects[J].Front Bioeng Biotechnol,2018,6:47.DOI: 10.3389/fbioe.2018.00047.
    [12]
    JiangY,TrotsyukAA,NiuS,et al.Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing[J].Nat Biotechnol,2023,41(5):652-662.DOI: 10.1038/s41587-022-01528-3.
    [13]
    PangQ,LouD,LiS,et al.Smart flexible electronics-integrated wound dressing for real-time monitoring and on-demand treatment of infected wounds[J].Adv Sci (Weinh),2020,7(6):1902673.DOI: 10.1002/advs.201902673.
    [14]
    University Hospitals of Derby and Burton NHS Foundation TrustTrials begin for smart wound sensors that could reduce amputations for patients with diabetes2023-05-102025-08-07https://www.uhdb.nhs.uk/LATEST-NEWS/TRIALS-BEGIN-FOR-SMART-WOUND-SENSORS-THAT-COULD-REDUCE-AMPUTATIONS-FOR-PATIENTS-WITH-DIABETES-15881/

    University Hospitals of Derby and Burton NHS Foundation Trust. Trials begin for smart wound sensors that could reduce amputations for patients with diabetes[EB/OL].(2023-05-10) [2025-08-07]. https://www.uhdb.nhs.uk/LATEST-NEWS/TRIALS-BEGIN-FOR-SMART-WOUND-SENSORS-THAT-COULD-REDUCE-AMPUTATIONS-FOR-PATIENTS-WITH-DIABETES-15881/.

    [15]
    GaoY,NguyenDT,YeoT,et al.A flexible multiplexed immunosensor for point-of-care in situ wound monitoring[J].Sci Adv,2021,7(21):eabg9614.DOI: 10.1126/sciadv.abg9614.
    [16]
    DingS, JinX, GuoJ, et al. A biomimetic asymmetric structured intelligent wound dressing with dual-modality humidity-pressure sensing for non-invasive and real-time wound healing monitoring[J/OL]. Adv Fiber Mater, 2025, 7(1): 156-171. DOI: 10.1007/s42765-024-00473-x.
    [17]
    ZhaoH, LiangG, XiongJ, et al. A closed-loop smart dressing based on microneedle and electrochemical micropump for early diagnosis and in-time therapy of chronic wound[J]. Sensors and Actuators B: Chemical, 2024, 417: 136092.
    [18]
    NgaDTNThuVTNOëLVet alAll-printed smart dressing for chronic wound monitoringProceedings of the 2023 IEEE International Flexible Electronics Technology Conference. IEEE2023https://ieeexplore.ieee.org/abstract/document/10254815DOI: 10.1109/IFETC57334.2023.10254815

    NgaDTN, ThuVT, NOëLV, et al. All-printed smart dressing for chronic wound monitoring[C/OL].Proceedings of the 2023 IEEE International Flexible Electronics Technology Conference. IEEE, 2023. https://ieeexplore.ieee.org/abstract/document/10254815. DOI: 10.1109/IFETC57334.2023.10254815.

    [19]
    XuG, LuY, ChengC, et al. Battery-free and wireless smart wound dressing for wound infection monitoring and electrically controlled on-demand drug delivery[J]. Adv Funct Mater, 2021, 31(26): 2100852.
    [20]
    Akhavan-KharazianN,Izadi-VasafiH,Tabashiri-IsfahaniM,et al.A review on smart dressings with advanced features[J].Wound Repair Regen,2025,33(3):e70014.DOI: 10.1111/wrr.70014.
    [21]
    KalidasanV,YangX,XiongZ,et al.Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds[J].Nat Biomed Eng,2021,5(10):1217-1227.DOI: 10.1038/s41551-021-00802-0.
    [22]
    ZhengXT,YangZ,SutarlieL,et al.Battery-free and AI-enabled multiplexed sensor patches for wound monitoring[J].Sci Adv,2023,9(24):eadg6670.DOI: 10.1126/sciadv.adg6670.
    [23]
    XinJ,GaoL,ZhangW,et al.A thermogalvanic cell dressing for smart wound monitoring and accelerated healing[J/OL].Nat Biomed Eng,2025(2025-07-14) [2025-08-07]. https://pubmed.ncbi.nlm.nih.gov/40659833/. DOI:10.1038/s41551-025-01440-6. [published online ahead of print].
    [24]
    PanzarasaG, OsypovaA, ToncelliC, et al. The pyranine-benzalkonium ion pair: a promising fluorescent system for the ratiometric detection of wound pH[J]. Sensors and Actuators B: Chemical, 2017, 249: 156-160.
    [25]
    JiL, XiaoY, XuK, et al. Smart bandage with multi-sensor system for wound healing and microenvironment monitoring[J]. Chem Eng J, 2025, 507: 160509.
    [26]
    XiaoY,XuK,ZhaoP,et al.Microgels sense wounds' temperature, pH and glucose[J].Biomaterials,2025,314:122813.DOI: 10.1016/j.biomaterials.2024.122813.
    [27]
    WangL,HouQ,ZhengW,et al.Fluorescent and antibacterial aminobenzeneboronic acid (ABA)-modified gold nanoclusters for self-monitoring residual dosage and smart wound care[J].ACS Nano,2021,15(11):17885-17894.DOI: 10.1021/acsnano.1c06139.
    [28]
    ChenY,WangX,TaoS,et al.Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties[J].Mil Med Res,2023,10(1):37.DOI: 10.1186/s40779-023-00473-9.
    [29]
    LuZ, SunC, HuP, et al. pH-responsive multifunctional drug-loaded covalent organic framework hydrogel dressing for enhanced bacteria-infected wound healing[J].Materials & Design, 2025, 257:114487. DOI: 10.1016/j.matdes.2025.114487.
    [30]
    YuR,ZhangH,GuoB.Conductive biomaterials as bioactive wound dressing for wound healing and skin tissue engineering[J].Nanomicro Lett,2021,14(1):1.DOI: 10.1007/s40820-021-00751-y.
    [31]
    KavetiR,JakusMA,ChenH,et al.Water-powered, electronics-free dressings that electrically stimulate wounds for rapid wound closure[J].Sci Adv,2024,10(32):eado7538.DOI: 10.1126/sciadv.ado7538.
    [32]
    KhalidA,BaiD,AbrahamAN,et al.Electrospun nanodiamond-silk fibroin membranes: a multifunctional platform for biosensing and wound-healing applications[J].ACS Appl Mater Interfaces,2020,12(43):48408-48419.DOI: 10.1021/acsami.0c15612.
    [33]
    LudmannD,TrompT,OttenH.Project ifoot - optimising the treatment of patients with diabetic foot syndrome with an intelligent dressing[J].Stud Health Technol Inform,2022,294:945-946.DOI: 10.3233/SHTI220633.
    [34]
    Shirzaei SaniE,XuC,WangC,et al.A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds[J].Sci Adv,2023,9(12):eadf7388.DOI: 10.1126/sciadv.adf7388.
    [35]
    GefenA. Promoting wound healing through artificial intelligence-powered dressing development[J]. Wounds International, 2025, 16(1): 30-33.
    [36]
    DengD, LiangL, SuK, et al. Smart hydrogel dressing for machine learning-enabled visual monitoring and promote diabetic wound healing[J]. Nano Today, 2025, 60: 102559.DOI: 10.1016/j.nantod.2024.102559.
    [37]
    卫志远,罗高兴. 同时具有原位检测和抑制细菌感染的响应性智能创面敷料加速创面愈合[J]. 中华烧伤杂志,2018(12):909.
    [38]
    潘泽平,韩波,陈孝强,等. 智能传感敷料的研究进展[J]. 中华烧伤杂志,2019,35(7):552-556. DOI: 10.3760/cma.j.issn.1009-2587.2019.07.016.
    [39]
    刘少辕, 张玉恒, 黄容, 等. 用于烧伤创面微环境监测的激光诱导石墨烯多模态电化学传感器的研制与性能评估[J]. 中华烧伤与创面修复杂志, 2025, 41(7): 688-697. DOI: 10.3760/cma.j.cn501225-20250215-00062.
    [40]
    BrönnekeJB, MüllerJ, MouratisK, et al. Regulatory, legal, and market aspects of smart wearables for cardiac monitoring[J]. Sensors (Basel), 2021, 21(14):4937. DOI: 10.3390/s21144937.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)

    Article Metrics

    Article views (105) PDF downloads(21) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return