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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  >  > Accepted Manuscript
Fang Yan,Ding Peijie,Fang Jie,et al.Research on the pharmacokinetics of linezolid in burn patients[J].Chin J Burns Wounds,2026,42(5):1-8.DOI: 10.3760/cma.j.cn501225-20251028-00447.
Citation: Fang Yan,Ding Peijie,Fang Jie,et al.Research on the pharmacokinetics of linezolid in burn patients[J].Chin J Burns Wounds,2026,42(5):1-8.DOI: 10.3760/cma.j.cn501225-20251028-00447.
shu

Research on the pharmacokinetics of linezolid in burn patients

doi: 10.3760/cma.j.cn501225-20251028-00447
  • 1.

    Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

  • 2.

    Departmnt of Pharmacy, Shanghai Geriatric Medical Center, Shanghai 201104, China

  • 3.

    Department of Burn, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

  • 4.

    Departmnt of Pharmacy, Xuzhou Central Hospital, Xuzhou 221009, China

Funds:

Shanghai Municipal Research Center for Burn and Wound Repair 2023ZZ02013

General Program of National Natural Science Foundation of China 8247090930, 82272262

More Information
  • Corresponding author: Shi Yan, Email: 18516130422@163.com
  • Received Date: 2025-10-28
    Available Online: 2026-04-30
    Abstract
  •   Objective  To analyze the pharmacokinetic differences of linezolid between burn patients and patients with pulmonary infection, and to explore the influencing factors.  Methods  This study was a retrospective cohort study. From August 1st, 2024 to August 1st, 2025, 74 burn patients (with 81 plasma trough concentration measurements) admitted to the Department of Burn of Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, who received linezolid treatment of 600 mg every 12 hours and completed monitoring of plasma trough concentration of linezolid (hereinafter referred to as plasma trough concentration) were included as burn group. There were 22 males and 52 females, aged 16-87 years. During the same period, 74 patients with pulmonary infection (with 75 plasma trough concentration measurements) admitted to the Department of Critical Care Medicine of the same hospital who received the same linezolid treatment and completed monitoring of plasma trough concentration were included as pulmonary infection group. There were 51 males and 23 females, aged 23-90 years. The plasma trough concentrations were detected at 30 min before the fifth administration using liquid chromatography-tandem mass spectrometry. In burn group of patients, the correlations between plasma trough concentration and age, body weight, total burn area, full-thickness burn area, admission time after burn, serum albumin level, serum creatinine level, and creatinine clearance rate were analyzed. In pulmonary infection group of patients, the correlations between plasma trough concentration and age, body weight, serum albumin level, serum creatinine level, and creatinine clearance rate were analyzed. The interactions of plasma trough concentration with age, body weight, serum albumin level, and serum creatinine level between the two groups of patients were analyzed.  Results  The plasma trough concentration of linezolid in burn group of patients was 2.30 (0.65, 5.70) mg/L, which was significantly lower than 4.07 (2.01, 7.82) mg/L in pulmonary infection group (Z=-3.131, P<0.05). The proportion of patients with plasma trough concentration <2 mg/L in burn group of patients was 46.9% (38/81), which was significantly higher than 22.67% (17/75) in pulmonary infection group (χ²=10.030, P<0.05). In burn group of patients, the plasma trough concentration was significantly positively correlated with age (rs=0.483, P<0.05), and significantly negatively correlated with body weight and full-thickness burn area (with rs of -0.247 and -0.231, respectively, P<0.05). In pulmonary infection group of patients, the plasma trough concentration was significantly negatively correlated with creatinine clearance rate (rs=-0.344, P<0.05), and significantly positively correlated with serum creatinine level (rs=0.255, P<0.05). Both in pulmonary infection group and burn group of patients, the plasma trough concentration showed a significant interaction with the serum albumin level (with β values of 0.201 and -0.145, respectively, 95%CI of -0.085 to 0.488 and -0.344 to 0.055, respectively, P<0.05).  Conclusions  Under the standard dosing regimen of linezolid, the plasma trough concentration in burn patients was significantly lower than that in patients with pulmonary infection, and the proportion of low drug exposure was higher. In burn patients, the plasma trough concentration was correlated with age, body weight, and full-thickness burn area. Both in burn patients and patients with pulmonary infection, the plasma trough concentration showed a significant interaction with serum albumin level.

     

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