Clinical effects of follicle unit extraction transplantation combined with recombinant bovine basic fibroblast growth factor and minoxidil in the treatment of secondary cicatricial alopecia

Yang Qing; Xue Ping; Dou Wenjie; Fan Xing; Song Baoqiang

doi:10.3760/cma.j.cn501120-20210416-00132

Volume 37 Issue 8

Aug. 2021

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2021 > 37(8): 718-724

Yang Q,Xue P,Dou WJ,et al.Clinical effects of follicle unit extraction transplantation combined with recombinant bovine basic fibroblast growth factor and minoxidil in the treatment of secondary cicatricial alopecia[J].Chin J Burns,2021,37(8):718-724.DOI: 10.3760/cma.j.cn501120-20210416-00132.

Citation:

PDF( 4330 KB)

Clinical effects of follicle unit extraction transplantation combined with recombinant bovine basic fibroblast growth factor and minoxidil in the treatment of secondary cicatricial alopecia

doi: 10.3760/cma.j.cn501120-20210416-00132

Department of Plastic and Reconstructive Surgery, the First Affiliated Hospital of Air Force Medical University, Xi′an 710032, China

More Information

Corresponding author: Xue Ping, Email: psdtwen@163.com
Received Date: 2021-04-16

Abstract

Abstract

Objective To explore the clinical effects of follicle unit extraction (FUE) transplantation combined with recombinant bovine basic fibroblast growth factor (rb-bFGF) gel and minoxidil tincture in treating secondary cicatricial alopecia (hereinafter referred to as cicatricial alopecia). Methods A retrospective observational study was conducted. According to the different treatment methods, 50 cicatricial alopecia patients who met the inclusion criteria and only underwent FUE transplantation in the First Affiliated Hospital of Air Force Medical University from March 2013 to April 2017 were recruited into FUE alone group (26 males and 24 females, aged (28±13) years), and 50 cicatricial alopecia patients who met the inclusion criteria and underwent FUE transplantation+rb-bFGF gel during 1 to 14 days after surgery+minoxidil tincture during 15 to 180 days after surgery in this hospital from May 2017 to April 2020 were recruited into FUE+rb-bFGF+minoxidil group (32 males and 18 females, aged (27±9) years). Hair loss rates in post surgery month (PSM) 3 and 6, hair survival rates and satisfaction rates of patients in PSM 12, and the adverse effect rates of patients in the 2 groups within PSM 12 were observed and calculated. Data were statistically analyzed with chi-square test, Fisher's exact probability test, and independent sample t test. Results In PSM 3 and 6, the hair loss rates of patients in FUE alone group were significantly higher than those in FUE+rb-bFGF+minoxidil group, respectively (t=70.850, 42.610, P<0.01). In PSM 12, the hair survival rate of patients in FUE+rb-bFGF+minoxidil group was (91.0±2.8)%, which was significantly higher than (80.9±6.9)% in FUE alone group (t=9.665, P<0.01). In PSM 12, 25 patients were very satisfied, 12 patients were fairly satisfied, 10 patients were slightly satisfied, 2 patients were not satisfied, and 1 patient was very unsatisfied in FUE alone group; 42 patients were very satisfied, 5 patients were fairly satisfied, and 3 patients were slightly satisfied in FUE+rb-bFGF+minoxidil group. The satisfaction rate of patients in FUE alone group was 74% (37/50), which was significantly lower than 94% (47/50) in FUE+rb-bFGF+minoxidil group (P<0.01). Within PSM 12, compared with those in FUE+rb-bFGF+minoxidil group, the incidence rates of folliculitis, abnormal growth direction, and skin necrosis in transplant site were not obviously changed in FUE alone group (P>0.05), while the incidence of scar in donor site was significantly higher (P<0.05). Conclusions Compared with FUE transplantation alone, FUE transplantation combined with rb-bFGF and minoxidil can reduce the hair loss rate, improve the hair survival rate and the satisfaction rate of patients with cicatricial alopecia after FUE transplantation, with less adverse effects, thus are good for cicatricial alopecia treatment.
- Cicatrix,
- Alopecia,
- Minoxidil,
- Follicle unit extraction,
- Recombinant bovine basic fibroblast growth factor

FullText(HTML)

References(30)

References

[1]	MuhammadA. Alopecia[M]. London: IntechOpen,2018:89-111.
[2]	YooH, MohJ, ParkJU. Treatment of postsurgical scalp scar deformity using follicular unit hair transplantation[J]. Biomed Res Int, 2019,2019:3423657. DOI: 10.1155/2019/3423657.
[3]	张伟, 陈莹, 王芳, 等. 毛囊单位提取移植术治疗瘢痕性秃发的临床应用和疗效观察[J]. 中华烧伤杂志,2021,37(5):469-474. DOI: 10.3760/cma.j.cn501120-20200315-00170.
[4]	王继萍, 范金财, 柴家科. 打孔同步植入毛囊单位法治疗烧伤后瘢痕性脱发[J]. 中华烧伤杂志, 2009, 25(6):411-414. DOI: 10.3760/cma.j.issn.1009-2587.2009.06.004.
[5]	田子红, 徐华飞, 田治国. 毛囊单位提取术治疗发际缘不同类型瘢痕性秃发临床观察[J]. 中华皮肤科杂志, 2017, 50 (12):923-925. DOI: 10.3760/cma.j.issn.0412-4030.2017.12.017.
[6]	LiKT, QuQ, FanZX, et al. Clinical experience on follicular unit extraction megasession for severe androgenetic alopecia[J]. J Cosmet Dermatol, 2020, 19(6):1481-1486. DOI: 10.1111/jocd.13156.
[7]	FanZX, GanYY, QuQ, et al. The effect of hyperbaric oxygen therapy combined with hair transplantation surgery for the treatment of alopecia[J]. J Cosmet Dermatol, 2021,20(3):917-921. DOI: 10.1111/jocd.13665.
[8]	SharmaR, RanjanA. Follicular unit extraction (FUE) hair transplant: curves ahead[J]. J Maxillofac Oral Surg, 2019,18(4):509-517. DOI: 10.1007/s12663-019-01245-6.
[9]	FarjoB, FarjoN, WilliamsG. Hair transplantation in burn scar alopecia[J]. Scars Burn Heal, 2015,1:2059513115607764. DOI: 10.1177/2059513115607764.
[10]	CaiBJ, ZhengYP, LiuXJ,et al. A crucial role of fibroblast growth factor 2 in the differentiation of hair follicle stem cells toward endothelial cells in a STAT5-dependent manner[J]. Differentiation,2020,111:70-78. DOI: 10.1016/j.diff.2019.10.004.
[11]	GentileP, GarcovichS, BielliA, et al. The effect of platelet-rich plasma in hair regrowth: a randomized placebo-controlled trial[J].Stem Cells Transl Med, 2015,4(11):1317-1323.DOI: 10.5966/sctm.2015-0107.
[12]	HuangWY, LinET, HsuYC, et al. Anagen hair follicle repair: timely regenerative attempts from plastic extra-bulge epithelial cells[J]. Exp Dermatol, 2019,28(4):406-412. DOI: 10.1111/exd.13889.
[13]	ChengXX, YuZ, SongYJ, et al. Hair follicle bulge-derived stem cells promote tissue regeneration during skin expansion[J]. Biomed Pharmacother, 2020,132:110805. DOI: 10.1016/j.biopha.2020.110805.
[14]	JoostS, JacobT, SunXY, et al. Single-cell transcriptomics of traced epidermal and hair follicle stem cells reveals rapid adaptations during wound healing[J].Cell Rep,2018,25(3):585-597.e7. DOI: 10.1016/j.celrep.2018.09.059.
[15]	AmohY, HoffmanRM. Hair follicle-associated-pluripotent (HAP) stem cells[J]. Cell Cycle, 2017,16(22):2169-2175. DOI: 10.1080/15384101.2017.1356513.
[16]	TakabayashiY, NambuM, IshiharaM, et al. Enhanced effect of fibroblast growth factor-2-containing dalteparin/protamine nanoparticles on hair growth[J]. Clin Cosmet Investig Dermatol, 2016,9:127-134. DOI: 10.2147/CCID.S108187.
[17]	AlvesR, GrimaltR. A review of platelet-rich plasma: history, biology, mechanism of action, and classification[J]. Skin Appendage Disord,2018,4(1):18-24. DOI: 10.1159/000477353.
[18]	YangQ, QiuLH, YiCG,et al. Reversible alopecia with localized scalp necrosis after accidental embolization of the parietal artery with hyaluronic acid[J]. Aesthetic Plast Surg, 2017,41(3):695-699. DOI: 10.1007/s00266-017-0841-z.
[19]	SuchonwanitP, ThammaruchaS, LeerunyakulK. Minoxidil and its use in hair disorders: a review[J]. Drug Des Devel Ther, 2019, 13:2777-2786. DOI: 10.2147/DDDT.S214907.
[20]	薛萍, 宋保强, 樊星, 等. 精细毛囊单位提取移植术修复瘢痕性眉缺损的临床效果[J]. 中华烧伤杂志,2021,37(7):661-665. DOI: 10.3760/cma.j.cn501120-20200316-00172.
[21]	GorenA, NaccaratoT. Minoxidil in the treatment of androgenetic alopecia[J]. Dermatol Ther,2018,31(5):e12686. DOI: 10.1111/dth.12686.
[22]	AvramMR, ColeJP, GandelmanM, et al. The potential role of minoxidil in the hair transplantation setting [J]. Dermatol Surg, 2002,28(10):894-900. DOI: 10.1046/j.1524-4725.2002.02068.x.
[23]	RamosPM, SinclairRD, KasprzakM, et al. Minoxidil 1 mg oral versus minoxidil 5% topical solution for the treatment of female-pattern hair loss: a randomized clinical trial[J]. J Am Acad Dermatol,2020,82(1):252-253. DOI: 10.1016/j.jaad.2019.08.060.
[24]	GargS. Outcome of intra-operative injected platelet-rich plasma therapy during follicular unit extraction hair transplant: a prospective randomised study in forty patients[J]. J Cutan Aesthet Surg, 2016,9(3):157-164. DOI: 10.4103/0974-2077.191657.
[25]	ParkJH, YouSH, KimNR. Nonshaven follicular unit extraction: personal experience[J]. Ann Plast Surg,2019,82(3):262-268.DOI: 10.1097/SAP.0000000000001679.
[26]	AbdelhakimM, LinXX, OgawaR. The Japanese experience with basic fibroblast growth factor in cutaneous wound management and scar prevention: a systematic review of clinical and biological aspects[J]. Dermatol Ther (Heidelb), 2020,10(4):569-587. DOI: 10.1007/s13555-020-00407-6.
[27]	XuanYH, ChiLS, TianHS, et al. The activation of the NF-κB-JNK pathway is independent of the PI3K-Rac1-JNK pathway involved in the bFGF-regulated human fibroblast cell migration[J].J Dermatol Sci, 2016,82(1):28-37. DOI: 10.1016/j.jdermsci.2016.01.003.
[28]	XuanYH, HuangBB, TianHS, et al. High-glucose inhibits human fibroblast cell migration in wound healing via repression of bFGF-regulating JNK phosphorylation[J]. PLoS One,2014,9(9):e108182. DOI: 10.1371/journal.pone.0108182.
[29]	WangX, ZhuYT, SunCC, et al. Feedback activation of basic fibroblast growth factor signaling via the Wnt/β-catenin pathway in skin fibroblasts[J]. Front Pharmacol,2017,8:32. DOI: 10.3389/fphar.2017.00032.
[30]	ShiHX, ChengY, YeJJ, et al. bFGF promotes the migration of human dermal fibroblasts under diabetic conditions through reactive oxygen species production via the PI3K/Akt-Rac1-JNK pathways[J]. Int J Biol Sci, 2015,11(7):845-859. DOI: 10.7150/ijbs.11921.