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Volume 37 Issue 8
Aug.  2021
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2021  >  37(8): 705-710
Zhang YX,Zhang SN.Clinical application and mechanism of botulinum toxin type A in scar treatment[J].Chin J Burns,2021,37(8):705-710.DOI: 10.3760/cma.j.cn501120-20210701-00232.
Citation: Zhang YX,Zhang SN.Clinical application and mechanism of botulinum toxin type A in scar treatment[J].Chin J Burns,2021,37(8):705-710.DOI: 10.3760/cma.j.cn501120-20210701-00232.
shu

Clinical application and mechanism of botulinum toxin type A in scar treatment

doi: 10.3760/cma.j.cn501120-20210701-00232

  • Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

Funds:

General Program of National Natural Science Foundation of China 81772098

Youth Program of National Natural Science Foundation of China 81801917, 81801918

Peak Plateau Plan of Shanghai Education Commission "Research Doctors" Project of China 20152227

Excellent Technology Leader Plan of Shanghai Science and Technology Commission of China 18XD1423700

Construction Project of Clinical Research Multidisciplinary Diagnosis and Treatment Team of Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine 2017-1-007

Clinical Research Booster Program of Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine JYLJ027

More Information
    Abstract
  • Pathological scars cause both local physical discomforts and mental disorders for patients. With the development of research, botulinum toxin type A (BTX-A) has been gradually used in the clinical treatment of scars. This article summarizes three potential mechanisms of BTX-A, including early tension reduction, inhibition of connective tissue hyperplasia, and alleviation of skin inflammation, as well as the clinical application of BTX-A in treating different types of scars. However, at present there is no uniform standard for the time, method, and proportioning of BTX-A injection for scar treatment, and there is also a lack of long-term follow-up results. Further researches are needed in future to clarify the mechanism of BTX-A in inhibiting scars, establish a uniform protocol of BTX-A injection, and provide a more effective treatment plan for scars.

     

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