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Volume 38 Issue 9
Sep.  2022
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2022  >  38(9): 849-853
Shi X, Zeng Z, Zhang YM,et al.Research advances on the interaction between Pseudomonas aeruginosa bacteriophages and the host[J].Chin J Burns Wounds,2022,38(9):849-853.DOI: 10.3760/cma.j.cn501120-20210929-00338.
Citation: Shi X, Zeng Z, Zhang YM,et al.Research advances on the interaction between Pseudomonas aeruginosa bacteriophages and the host[J].Chin J Burns Wounds,2022,38(9):849-853.DOI: 10.3760/cma.j.cn501120-20210929-00338.
shu

Research advances on the interaction between Pseudomonas aeruginosa bacteriophages and the host

doi: 10.3760/cma.j.cn501120-20210929-00338
  • 1.

    Department of Plastic and Cosmetic Surgery, the Second Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400037, China

  • 2.

    State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China

Funds:

General Program of National Natural Science Foundation of China 81772073

Youth Science Foundation Project of National Natural Science Foundation of China 82002051

Foundation of Open Projects from State Key Laboratory of Trauma, Burns and Combined Injury SKLKF201918

General Program of Natural Science Foundation of Chongqing cstc2021jcyj-msxmX0655

Chongqing Doctor "Through Train" Project CSTB2022BSXM-JCX0019

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    Abstract
  • Pseudomonas aeruginosa is the most common pathogen of burn wound infection. It can encode a variety of virulence factors and is highly pathogenic, which can lead to poor prognosis and high mortality. In order to research a new method to combat Pseudomonas aeruginosa infection, researchers have observed a wide range of interactions between the bacteriophages and the host. Bacteriophages influence and even dominate the structure, movement, and metabolism of host bacteria through a variety of mechanisms, catalyze the evolution of the host, and are also an important factor in host environmental adaptability and pathogenicity. In this paper, the interaction between Pseudomonas aeruginosa bacteriophages and the host is reviewed from the single cell level and the population level. Understanding these interactions could provide new idea for the treatment of Pseudomonas aeruginosa clinical infections, provides a basis for future development of antimicrobial agents and guides the treatment of burn infections.

     

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