Volume 39 Issue 7
Jul.  2023
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Duan YR,Zhao YC,Song WY,et al.Research advances on improving the therapeutic efficacy of mesenchymal stem cell-derived exosomes in wound repair[J].Chin J Burns Wounds,2023,39(7):695-700.DOI: 10.3760/cma.j.cn501225-20220912-00402.
Citation: Duan YR,Zhao YC,Song WY,et al.Research advances on improving the therapeutic efficacy of mesenchymal stem cell-derived exosomes in wound repair[J].Chin J Burns Wounds,2023,39(7):695-700.DOI: 10.3760/cma.j.cn501225-20220912-00402.

Research advances on improving the therapeutic efficacy of mesenchymal stem cell-derived exosomes in wound repair

doi: 10.3760/cma.j.cn501225-20220912-00402
Funds:

Shanxi Provincial Basic Research Program Youth Science Research Project 202103021223412

More Information
  • Corresponding author: Wang Xiaobing, Email: xiaobingw1970@163.com
  • Received Date: 2022-09-12
    Available Online: 2023-07-19
  • How to promote high-quality wound healing is a common problem for plastic surgery and burn physicians. In recent years, numerous animal studies have demonstrated that mesenchymal stem cell-derived exosomes promote wound repair through multiple mechanisms and are promising cell-free therapeutic agents with broad prospect of application. How to enhance the therapeutic efficacy of exosomes, optimize their drug delivery strategy, and improve their biological properties are the challenges to be overcome in order to move from basic research to clinical application of exosome therapy for wound repair. This article focuses on methods to improve the wound repair potential of mesenchymal stem cell-derived exosomes, and reviews the recent research advances on improving the therapeutic efficacy of mesenchymal stem cell-derived exosomes in wound repair from three aspects, including pretreatment of parental mesenchymal stem cells, hydrogel bio-scaffold loaded with exosomes, and engineered exosomes, to provide a reference for further clinical studies.

     

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