Research advances on improving the therapeutic efficacy of mesenchymal stem cell-derived exosomes in wound repair

Duan Yuren; Zhao Yuchen; Song Wenyu; Wang Jiaxin; Pei Jie; Wang Xiaobing

doi:10.3760/cma.j.cn501225-20220912-00402

Volume 39 Issue 7

Jul. 2023

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2023 > 39(7): 695-700

Duan YR,Zhao YC,Song WY,et al.Research advances on improving the therapeutic efficacy of mesenchymal stem cell-derived exosomes in wound repair[J].Chin J Burns Wounds,2023,39(7):695-700.DOI: 10.3760/cma.j.cn501225-20220912-00402.

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Research advances on improving the therapeutic efficacy of mesenchymal stem cell-derived exosomes in wound repair

doi: 10.3760/cma.j.cn501225-20220912-00402

1.
Department of Burns and Plastic Surgery, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
2.
Department of Burns and Plastic Surgery, Xianyang Central Hospital, Xianyang 712099, China
3.
Department of Plastic Surgery, Shanxi Bethune Hospital (Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), the Third Hospital of Shanxi Medical University, Taiyuan 030032, China

Funds:

Shanxi Provincial Basic Research Program Youth Science Research Project 202103021223412

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Corresponding author: Wang Xiaobing, Email: xiaobingw1970@163.com
Received Date: 2022-09-12
Available Online: 2023-07-19

Abstract

Abstract

How to promote high-quality wound healing is a common problem for plastic surgery and burn physicians. In recent years, numerous animal studies have demonstrated that mesenchymal stem cell-derived exosomes promote wound repair through multiple mechanisms and are promising cell-free therapeutic agents with broad prospect of application. How to enhance the therapeutic efficacy of exosomes, optimize their drug delivery strategy, and improve their biological properties are the challenges to be overcome in order to move from basic research to clinical application of exosome therapy for wound repair. This article focuses on methods to improve the wound repair potential of mesenchymal stem cell-derived exosomes, and reviews the recent research advances on improving the therapeutic efficacy of mesenchymal stem cell-derived exosomes in wound repair from three aspects, including pretreatment of parental mesenchymal stem cells, hydrogel bio-scaffold loaded with exosomes, and engineered exosomes, to provide a reference for further clinical studies.
- Mesenchymal stem cells,
- Exosomes,
- Hydrogel,
- Wound repair

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Research advances on improving the therapeutic efficacy of mesenchymal stem cell-derived exosomes in wound repair

doi: 10.3760/cma.j.cn501225-20220912-00402

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Research advances on improving the therapeutic efficacy of mesenchymal stem cell-derived exosomes in wound repair

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