Transcriptomic research on severe burns: value and prospects

Jia Chiyu; Yin Bin; Zhang Zexin

doi:10.3760/cma.j.cn501225-20231026-00135

Volume 40 Issue 6

Jun. 2024

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2024 > 40(6): 514-520

Jia CY,Yin B,Zhang ZX.Transcriptomic research on severe burns: value and prospects[J].Chin J Burns Wounds,2024,40(6):514-520.DOI: 10.3760/cma.j.cn501225-20231026-00135.

Citation:

Jia CY,Yin B,Zhang ZX.Transcriptomic research on severe burns: value and prospects[J].Chin J Burns Wounds,2024,40(6):514-520.DOI: 10.3760/cma.j.cn501225-20231026-00135.

Citation:

Jia CY,Yin B,Zhang ZX.Transcriptomic research on severe burns: value and prospects[J].Chin J Burns Wounds,2024,40(6):514-520.DOI: 10.3760/cma.j.cn501225-20231026-00135.

PDF( 1123 KB)

Transcriptomic research on severe burns: value and prospects

doi: 10.3760/cma.j.cn501225-20231026-00135

Jia Chiyu^{1
,
,},
Yin Bin¹,
Zhang Zexin²

1.
Center of BurnPlastic and Wound Repair Surgery, the First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China
2.
School of Medicine, Xiamen University, Xiamen 361100, China

Funds:

Young Investigator Research Program of Xiang'an Hospital of Xiamen University XM01120001

Fujian Provincial Health Science and Technology Plan Project 2020TG028

More Information

Corresponding author: Jia Chiyu, Email: jiachiyu@qq.com
Received Date: 2023-10-26

Abstract

Abstract

Transcriptomics technology has shown remarkable application effects in multiple disease fields, but its application in severe burns, especially in the field of burn sepsis, is still superficial. The use of transcriptomics and big data methods to solve the long-standing challenges of severe burns, especially in the field of burn sepsis, has great prospects and significance. This article comprehensively discusses the application value, current status, and future prospects of transcriptomics in the study of severe burns, especially burn sepsis, in order to provide new ideas for the treatment of severe burns.
- Burns,
- Transcriptome,
- Sepsis,
- Immunosuppression

FullText(HTML)

References(43)

References

[1]	DeJesusJE,WenJJ,RadhakrishnanR.Cytokine pathways in cardiac dysfunction following burn injury and changes in genome expression[J].J Pers Med,2022,12(11):1876.DOI: 10.3390/jpm12111876.
[2]	GuoY,YouY,LvD,et al.Inducible nitric oxide synthase contributes to insulin resistance and cardiac dysfunction after burn injury in mice[J].Life Sci,2019,239:116912.DOI: 10.1016/j.lfs.2019.116912.
[3]	CarlsonDL,HortonJW.Cardiac molecular signaling after burn trauma[J].J Burn Care Res,2006,27(5):669-675.DOI: 10.1097/01.BCR.0000237955.28090.41.
[4]	YangHT,YimH,ChoYS,et al.Assessment of biochemical markers in the early post-burn period for predicting acute kidney injury and mortality in patients with major burn injury: comparison of serum creatinine, serum cystatin-C, plasma and urine neutrophil gelatinase-associated lipocalin[J].Crit Care,2014,18(4):R151.DOI: 10.1186/cc13989.
[5]	TaoF,TianX,LuM,et al.A novel lncRNA, Lnc-OC1, promotes ovarian cancer cell proliferation and migration by sponging miR-34a and miR-34c[J].J Genet Genomics,2018,45(3):137-145.DOI: 10.1016/j.jgg.2018.03.001.
[6]	AhluwaliaP,KolheR,GahlayGK.The clinical relevance of gene expression based prognostic signatures in colorectal cancer[J].Biochim Biophys Acta Rev Cancer,2021,1875(2):188513.DOI: 10.1016/j.bbcan.2021.188513.
[7]	Solé-BoldoL,RaddatzG,GutekunstJ,et al.Differentiation-related epigenomic changes define clinically distinct keratinocyte cancer subclasses[J].Mol Syst Biol,2022,18(9):e11073.DOI: 10.15252/msb.202211073.
[8]	FangX,DuanSF,GongYZ,et al.Identification of key genes associated with changes in the host response to severe burn shock: a bioinformatics analysis with data from the gene expression omnibus (GEO) database[J].J Inflamm Res,2020,13:1029-1041.DOI: 10.2147/JIR.S282722.
[9]	WangP,ZhangZ,YinB,et al.Identifying changes in immune cells and constructing prognostic models using immune-related genes in post-burn immunosuppression[J].PeerJ,2022,10:e12680.DOI: 10.7717/peerj.12680.
[10]	WuRX,ChiuCC,LinTC,et al.Procalcitonin as a diagnostic biomarker for septic shock and bloodstream infection in burn patients from the Formosa Fun Coast dust explosion[J].J Microbiol Immunol Infect,2017,50(6):872-878.DOI: 10.1016/j.jmii.2016.08.021.
[11]	TokarikM,SjöbergF,VajtrD,et al.Natriuretic peptide proANP (1-98), a biomarker of ALI/ARDS in burns[J].Burns,2013,39(2):243-248.DOI: 10.1016/j.burns.2012.06.010.
[12]	LiAT,MoussaA,GusE,et al.Biomarkers for the early diagnosis of sepsis in burns: systematic review and meta-analysis[J].Ann Surg,2022,275(4):654-662.DOI: 10.1097/SLA.0000000000005198.
[13]	LiuX,RongY,HuangD,et al.Altered genes and biological functions in response to severe burns[J].Biomed Res Int,2021,2021:8836243.DOI: 10.1155/2021/8836243.
[14]	ZhangZ,PanQ,GeH,et al.Deep learning-based clustering robustly identified two classes of sepsis with both prognostic and predictive values[J].EBioMedicine,2020,62:103081.DOI: 10.1016/j.ebiom.2020.103081.
[15]	ZhangZ,HeY,LinR,et al.Identification of important modules and biomarkers that are related to immune infiltration cells in severe burns based on weighted gene co-expression network analysis[J].Front Genet,2022,13:908510.DOI: 10.3389/fgene.2022.908510.
[16]	BajJ,Korona-GłowniakI,BuszewiczG,et al.Viral infections in burn patients: a state-of-the-art review[J].Viruses,2020,12(11):1315.DOI: 10.3390/v12111315.
[17]	EngelmannI,PetzoldDR,KosinskaA,et al.Rapid quantitative PCR assays for the simultaneous detection of herpes simplex virus, varicella zoster virus, cytomegalovirus, Epstein-Barr virus, and human herpesvirus 6 DNA in blood and other clinical specimens[J].J Med Virol,2008,80(3):467-477.DOI: 10.1002/jmv.21095.
[18]	BrennanPG,WrightK,MilesMVP,et al.Delineating the role of serum immunoglobulin titers in burn patients at high risk for herpes simplex virus infection[J].J Burn Care Res,2021,42(4):646-650.DOI: 10.1093/jbcr/irz197.
[19]	WangP,ZhangZ,LinR,et al.Machine learning links different gene patterns of viral infection to immunosuppression and immune-related biomarkers in severe burns[J].Front Immunol,2022,13:1054407.DOI: 10.3389/fimmu.2022.1054407.
[20]	ZhengY,LiuB,DengX,et al.Construction and validation of a robust prognostic model based on immune features in sepsis[J].Front Immunol,2022,13:994295.DOI: 10.3389/fimmu.2022.994295.
[21]	ZhouB,XuW,HerndonD,et al.Analysis of factorial time-course microarrays with application to a clinical study of burn injury[J].Proc Natl Acad Sci U S A,2010,107(22):9923-9928.DOI: 10.1073/pnas.1002757107.
[22]	WuD,ZhouM,LiL,et al.Severe burn injury progression and phasic changes of gene expression in mouse model[J].Inflammation,2019,42(4):1239-1251.DOI: 10.1007/s10753-019-00984-5.
[23]	WuD,ZhouM,LiL,et al.Time series analysis of gene changes and processes after burn with human gene expression profiles[J].Burns,2019,45(2):387-397.DOI: 10.1016/j.burns.2018.08.022.
[24]	夏照帆,伍国胜.浅谈细胞因子在脓毒症中的作用及临床应用现状[J].中华烧伤杂志,2019,35(1):3-7.DOI: 10.3760/cma.j.issn.1009-2587.2019.01.002.
[25]	DemlingRH.The burn edema process: current concepts[J].J Burn Care Rehabil,2005,26(3):207-227.
[26]	PhamTN,CancioLC,GibranNS.American Burn Association practice guidelines burn shock resuscitation[J].J Burn Care Res,2008,29(1):257-266.DOI: 10.1097/BCR.0b013e31815f3876.
[27]	SabryA,El-DinAB,El-HadidyAM,et al.Markers of tubular and glomerular injury in predicting acute renal injury outcome in thermal burn patients: a prospective study[J].Ren Fail,2009,31(6):457-463.DOI: 10.1080/08860220902963616.
[28]	WilliamsFN,HerndonDN,JeschkeMG.The hypermetabolic response to burn injury and interventions to modify this response[J].Clin Plast Surg,2009,36(4):583-596.DOI: 10.1016/j.cps.2009.05.001.
[29]	WangY,YinX,YangF.Comprehensive analysis of gene expression profiles of sepsis-induced multiorgan failure identified its valuable biomarkers[J].DNA Cell Biol,2018,37(2):90-98.DOI: 10.1089/dna.2017.3944.
[30]	DengH,LiJ,Ali ShahA,et al.Commonly expressed key transcriptomic profiles of sepsis in the human circulation and brain via integrated analysis[J].Int Immunopharmacol,2022,104:108518.DOI: 10.1016/j.intimp.2022.108518.
[31]	ChenM,SuW,ChenF,et al.Mechanisms underlying the therapeutic effects of 4-octyl itaconate in treating sepsis based on network pharmacology and molecular docking[J].Front Genet,2022,13:1056405.DOI: 10.3389/fgene.2022.1056405.
[32]	JekarlDW,KimKS,LeeS,et al.Cytokine and molecular networks in sepsis cases: a network biology approach[J].Eur Cytokine Netw,2018,29(3):103-111.DOI: 10.1684/ecn.2018.0414.
[33]	CuiS,NiuK,XieY,et al.Screening of potential key ferroptosis-related genes in sepsis[J].PeerJ,2022,10:e13983.DOI: 10.7717/peerj.13983.
[34]	GanY,LongJ,ZengY,et al.lncRNA IL-17RA-1 attenuates LPS-induced sepsis via miR-7847-3p/PRKCG-mediated MAPK signaling pathway[J].Mediators Inflamm,2022,2022:9923204.DOI: 10.1155/2022/9923204.
[35]	SchwachaMG,ChaudryIH.The cellular basis of post-burn immunosuppression: macrophages and mediators[J].Int J Mol Med,2002,10(3):239-243.
[36]	HuangJ,ZhuZ,JiD,et al.Single-cell transcriptome profiling reveals neutrophil heterogeneity and functional multiplicity in the early stage of severe burn patients[J].Front Immunol,2021,12:792122.DOI: 10.3389/fimmu.2021.792122.
[37]	ReyesM,FilbinMR,BhattacharyyaRP,et al.An immune-cell signature of bacterial sepsis[J].Nat Med,2020,26(3):333-340.DOI: 10.1038/s41591-020-0752-4.
[38]	KokhaeiP,BaroughMS,HassanZM.Cimetidine effects on the immunosuppression induced by burn injury[J].Int Immunopharmacol,2014,22(1):273-276.DOI: 10.1016/j.intimp.2014.07.003.
[39]	DardenDB,BacherR,BruskoMA,et al.Single-cell RNA-seq of human myeloid-derived suppressor cells in late sepsis reveals multiple subsets with unique transcriptional responses: a pilot study[J].Shock,2021,55(5):587-595.DOI: 10.1097/SHK.0000000000001671.
[40]	McBrideMA,PatilTK,BohannonJK,et al.Immune checkpoints: novel therapeutic targets to attenuate sepsis-induced immunosuppression[J].Front Immunol,2020,11:624272.DOI: 10.3389/fimmu.2020.624272.
[41]	LiZ,ZhangC,LiuY,et al.Diagnostic and predictive values of ferroptosis-related genes in child sepsis[J].Front Immunol,2022,13:881914.DOI: 10.3389/fimmu.2022.881914.
[42]	YinB,HeY,ZhangZ,et al.Global burden of burns and its association with socio-economic development status, 1990-2019[J].Burns,2024,50(2):321-374.DOI: 10.1016/j.burns.2023.02.007.
[43]	YaoRQ,LiZX,WangLX,et al.Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis[J].Theranostics,2022,12(10):4606-4628.DOI: 10.7150/thno.72760.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1)

Get Citation

PDF

XML

Article Metrics

Article views (104) PDF downloads(13)

Transcriptomic research on severe burns: value and prospects

doi: 10.3760/cma.j.cn501225-20231026-00135

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Transcriptomic research on severe burns: value and prospects

doi: 10.3760/cma.j.cn501225-20231026-00135

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content