Meek skin grafting combined with platelet-rich plasma in repairing of extensive deep burn wounds: a clinical study

Zhang Ting; Liu Jiaqi; Yang Yunshu; Han Juntao; Hu Dahai; Zheng Zhao

doi:10.3760/cma.j.cn501225-20231124-00206

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > > Accepted Manuscript

Zhang Ting,Liu Jiaqi,Yang Yunshu,et al.Meek skin grafting combined with platelet-rich plasma in repairing of extensive deep burn wounds: a clinical study[J].Chin J Burns Wounds,2024,40(12):1-7.DOI: 10.3760/cma.j.cn501225-20231124-00206.

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Meek skin grafting combined with platelet-rich plasma in repairing of extensive deep burn wounds: a clinical study

doi: 10.3760/cma.j.cn501225-20231124-00206

Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an710032, China

Funds:

Key Research and Development Plan of Shaanxi Province of China 2022SF-399

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Corresponding author: Zheng Zhao, Email: zz73553@163.com
Received Date: 2023-11-24
Available Online: 2024-12-02

Abstract

Abstract

Objective To investigate the clinical effects of Meek skin grafting combined with platelet-rich plasma (PRP) in repairing of extensive deep burn wounds. Methods This study was a retrospective observational study. From August 2018 to August 2023, 44 patients who met the inclusion criteria were admitted to the First Affiliated Hospital of Air Force Medical University, including 23 males and 21 females. Their age ranged from 22 to 62 years old and the total burn area was 30%TBSA-80%TBSA, the burns on limbs or torso were deep partial-thickness to full-thickness. According to the treatment process, the patients were divided into observation group (21 cases) and control group (23 cases). For deep burns on the limbs or torso, patients in observation group were treated with Meek skin grafting combined with PRP at the same time, while patients in control group were treated with Meek skin grafting alone. The survival rate of Meek skin grafts was observed on the 10^th day after operation. The wound healing rate of patients was observed on the 14^th day after operation. The postoperative wound healing time and positive rate of bacterial culture of wound specimens were recorded. Results On the 10^th day after operation, the skin grafting area in observation group were dry, and the skin grafts adhered closely to the wound base with ruddy color, with a survival rate of 89%±4%. Whereas in control group, some skin grafts fell off, and the residual wounds were scattered in irregular map shape, accompanied by purulent secretion. The survival rate of skin grafts was about 79%±6%, which was significantly lower than that in observation group (t=6.72, P<0.05). On the 14^th day after operation, 19 patients in observation group had complete wound healing in the operation area, and the other 2 patients had small residual wounds, which healed after 1 week of dressing change; in control group, 12 patients had complete wound healing, 6 patients had wound healing after supplementary stamp skin grafting, and 5 patients had delayed wound healing after dressing change. The wound healing rate was significantly lower than that in observation group (P<0.05). The wound healing time of the operation area in observation group was (13.29±1.65) days, which was significantly shorter than (16.39±3.49) days in control group (t=3.72, P<0.05). There was no statistically significant difference in the positive rate of bacterial culture of wound specimens between the two groups after operation. Conclusions Compared with Meek skin grafting alone, Meek skin grafting combined with autologous PRP can improve the therapeutic effect in the repairing of extensive deep burn wounds, by promoting the survival of skin grafts, accelerating the expansion and fusion of skin grafts, and shortening the wound healing time.
- Burns,
- Platelet-rich plasma,
- Extensive deep burns,
- Meek skin grafting,
- Wound repair

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References(36)

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