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Volume 41 Issue 7
Jul.  2025
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2025  >  41(7): 703-707
Zhao Siyuan, Li Wei, Kong Weishi, et al. Research advances on the application of skin organoids in wound repair[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2025, 41(7): 703-707. Doi: 10.3760/cma.j.cn501225-20240901-00323
Citation: Zhao Siyuan, Li Wei, Kong Weishi, et al. Research advances on the application of skin organoids in wound repair[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2025, 41(7): 703-707. Doi: 10.3760/cma.j.cn501225-20240901-00323
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Research advances on the application of skin organoids in wound repair

doi: 10.3760/cma.j.cn501225-20240901-00323

  • Burn Institute of PLA, Department of Burn Trauma and Wound Repair, the First Affiliated Hospital of Naval Medical University, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, Shanghai 200433, China

Funds:

Scientific and Research Program of Shanghai Municipal Health Commission 20244Z0009

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    Abstract
  • Skin is an organ with complex structure and function. Extensive skin defects and chronic non-healing wounds cause serious problems for patients and clinicians, while traditional repair methods are still not able to completely reconstruct the structure and function of skin. To achieve complete reconstruction of skin structure and function is a great challenge that needs to be solved in the field of wound repair. Induced pluripotent stem cells, which have the potential to differentiate into any human cells, are widely used in the field of regenerative medicine research. In recent years, skin organoids constructed through in vitro cultivation of stem cells contain epidermis, dermis, and multiple skin appendages, which overcomes the limitations of traditional skin substitute and opens new avenues for wound repair and its basic research. This review outlines the status of the research and application of skin organoids and discusses their current challenges in clinical translation and prospects for development.

     

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