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Volume 42 Issue 2
Feb.  2026
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2026  >  42(2): 196-202
Hu YJ,Wang XY,Jiang DY.Research progress on energy metabolism disorders in diabetic foot ulcers[J].Chin J Burns Wounds,2026,42(2):196-202.DOI: 10.3760/cma.j.cn501225-20241015-00387.
Citation: Hu YJ,Wang XY,Jiang DY.Research progress on energy metabolism disorders in diabetic foot ulcers[J].Chin J Burns Wounds,2026,42(2):196-202.DOI: 10.3760/cma.j.cn501225-20241015-00387.
shu

Research progress on energy metabolism disorders in diabetic foot ulcers

doi: 10.3760/cma.j.cn501225-20241015-00387

  • Department of Burns and Plastic Surgery, the Second Qilu Hospital of Shandong University, Jinan 250033, China

Funds:

General Program of National Natural Science Foundation of China 81873934

Growth Factor Rejuvenation Plan of Wang Zhengguo Foundation for Traumatic Medicine SZYZ-TR-09

Science and Technology Development Projects of Shandong Province 2015GSF118041

Jinan Science and Technology Plan Project 202225065

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    Abstract
  • Diabetic foot ulcer (DFU) represents a common and difficult-to-treat complication in diabetic patients. During the initiation and progression of DFU, the impaired energy metabolism in patients leads to a spectrum of pathological processes, including vasculopathy and neuropathy. Through pseudo-hypoxia, oxidative stress, and chronic inflammation, the energy metabolism disorders can result in metabolic reprogramming and functional dysregulation of immune and reparative cells, ultimately leading to ulcer formation and delayed wound healing. This review summarized the intrinsic relationship between common energy substance metabolism disorders in DFU patients and the onset and progression of DFU, the impact of energy metabolism disorders on wound cells in DFU, as well as the foundational and clinical research progress on targeted energy metabolism therapy for DFU.

     

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