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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  >  > Accepted Manuscript
Zhang Binzhu,Lin Feng,Zuo Na,et al.Efficacy of collagenase ointment in treating deep partial-thickness burn wounds in infants and young children[J].Chin J Burns Wounds,2026,42(4):1-8.DOI: 10.3760/cma.j.cn501225-20241211-00485.
Citation: Zhang Binzhu,Lin Feng,Zuo Na,et al.Efficacy of collagenase ointment in treating deep partial-thickness burn wounds in infants and young children[J].Chin J Burns Wounds,2026,42(4):1-8.DOI: 10.3760/cma.j.cn501225-20241211-00485.
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Efficacy of collagenase ointment in treating deep partial-thickness burn wounds in infants and young children

doi: 10.3760/cma.j.cn501225-20241211-00485

  • Department of Burn and Plastic Microsurgery, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China

Funds:

Liaoning Provincial Science and Technology Plan Project 2021JH2/10300108

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  • Corresponding author: Tao Kai, Email: 13309887570@vip.163.com
  • Received Date: 2024-12-11
    Available Online: 2026-03-30
    Abstract
  •   Objective  To investigate the efficacy of collagenase ointment in treating deep partial-thickness burn wounds in infants and young children.  Methods  This study was a retrospective cohort study. From September 2019 to September 2023, 40 infants and young children with deep partial-thickness burns who met the inclusion criteria were admitted to the Fourth Affiliated Hospital of China Medical University. There were 22 males and 18 females, aged 10-36 months. According to the wound management method, the children were divided into observation group (n=20) treated with initial collagenase ointment followed by later vaseline gauze, and control group (n=20) treated with vaseline gauze alone. The wound necrotic tissue detachment time and wound healing time of pediatric patients were recorded. Pain of pediatric patients was assessed using the Neonatal Infant Pain Scale (NIPS), the CRIES pain score scale, and the children's pain behavior inventory FLACC during each dressing change and every 2 days after treatment, and the mean value of multiple measurements was used for statistical analysis. The duration of adverse symptoms of pediatric patients within 7 days after the start of treatment, as well as the occurrence of adverse reactions and wound infection, and detection of pathogenic microorganisms of pediatric patients during the treatment period were recorded.  Results  The wound necrotic tissue detachment time and wound healing time of pediatric patients in observation group were (4.2±2.8) and (15.4±3.2) d, respectively, which were significantly shorter than (8.3±1.5) and (22.8±2.1) d in control group (with mean differences of -4.2 and -7.3 d, respectively, 95% CI of -5.6--2.7 and -9.0--5.6 d, respectively, t values of 6.656 and 9.354, respectively, P values both <0.05). Analysis of covariance showed that after adjusting for potential confounding factors, the wound necrotic tissue detachment time and wound healing time of pediatric patients in observation group were still significantly shorter than those in control group (with mean differences of -4.1 and -7.4 d, respectively, 95% CI of -5.5--2.7 and -9.1--5.7 d, respectively, F values of 25.831 and 68.152, respectively, P<0.05). During each dressing change and every 2 days after treatment, there were no statistically significant differences in the NIPS, CRIES pain score scale, and FLACC scores for pain between the two groups of pediatric patients (P>0.05). Within 7 days after the start of treatment, the duration of adverse symptoms of pediatric patients in observation group was (2.0±0.7) d, which was significantly shorter than (5.2±0.8) d in control group (t=12.823, P<0.05). During the treatment period, the proportions of pediatric patients with adverse reactions, wound infection, and detected pathogenic microorganisms in observation group were lower than those in control group, but the differences were not statistically significant (P>0.05).  Conclusions  Collagenase ointment can significantly shorten the necrotic tissue detachment time and wound healing time of deep partial-thickness burn wounds in infants and young children, and shorten the duration of early adverse symptoms. Although it did not show significant advantages in reducing pain scores or incidence of complication, it has potential value in clinical application.

     

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