Clinical efficacy of punch excision combined with early radiotherapy in multiple keloids

Tang Yuchen; Xu Shun; Zhang Yixin; Zhang Zheng

doi:10.3760/cma.j.cn501225-20241226-00508

Volume 42 Issue 4

Apr. 2026

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2026 > 42(4): 342-349

Tang YC,Xu S,Zhang YX,et al.Clinical efficacy of punch excision combined with early radiotherapy in multiple keloids[J].Chin J Burns Wounds,2026,42(4):342-349.DOI: 10.3760/cma.j.cn501225-20241226-00508.

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Clinical efficacy of punch excision combined with early radiotherapy in multiple keloids

doi: 10.3760/cma.j.cn501225-20241226-00508

1.
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
2.
Department of Burn and Plastic Surgery, Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China

Funds:

General Program of National Natural Science Foundation of China 82172222, 82272266

The Featured Clinical Discipline Project of Shanghai Pudong PWYts2021-16

Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support 20152227

More Information

Corresponding author: Zhang Zheng, Email: zhangzheng958@163.com
Received Date: 2024-12-26

Abstract

Abstract

Objective To evaluate the clinical efficacy of punch excision combined with early radiotherapy (PCR) in multiple keloids. Methods This study was a retrospective cohort study. From November 2022 to December 2023, 32 patients with multiple keloids who met the inclusion criteria were recruited from the Department of Plastic and Reconstructive Surgery of Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. Among them, 20 were male and 12 were female, aged 16 to 74 years. All patients underwent PCR. At one year after surgery, the efficacy of the treatment in 32 patients was evaluated based on the symptoms, the degree of improvement, and the recurrence of keloids. The treatment effectiveness rate and recurrence rate were calculated. The Vancouver scar scale (VSS) was used to score the keloids of 32 patients in terms of pigmentation, height, pliability, and vascularity before surgery, at 6 months and one year after surgery. The image and data from skin imaging analysis system of 17 patients were collected before surgery and at 6 months and one year after surgery. Then the hemoglobin, melanin, and volume of keloids were scored. Results At one year after surgery, the results of efficacy evaluation of 32 patients showed that 22 cases were markedly effective, 6 cases were improved, 3 cases were ineffective, and one case recurred. The treatment effectiveness rate was 87.50% (28/32), and the recurrence rate was 3.12% (1/32). The total score and scores of pigmentation, height, vascularity, and pliability of VSS of keloids of 32 patients at one year after surgery were significantly lower than those before surgery and at 6 months after surgery (with t values of 14.501, 2.470, 13.552, 7.779, 15.092 and 6.297, 5.298, 3.040, 3.832, 4.477, respectively, P<0.05). The volume score of keloids of 17 patients at one year after surgery was significantly lower than that before surgery and at 6 months after surgery (with Z values of 3.772 and 4.860, respectively, P values both <0.05). However, there were no statistically significant differences in hemoglobin or melanin scores of keloids between one year after surgery and before surgery or 6 months after surgery (P>0.05). Conclusions PCR can significantly reduce the volume of multiple keloids, improve appearance and pliability of keloids. It is a safe and effective clinical treatment plan with definite efficacy and low recurrence rate of keloids.
- Cicatrix,
- Keloid,
- Radiotherapy, high-energy,
- Recurrence,
- Punch excision

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References(40)

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