Research advances on the application of exosomal multi-omics analysis technology in warning and diagnosis of burn sepsis

Chen Yuxi; Luo Liang; Jiang Shiqing; Wang Yunchuan; Hu Dahai

doi:10.3760/cma.j.cn501225-20250512-00222

Volume 41 Issue 7

Jul. 2025

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Article Navigation > CHINESE JOURNAL OF BURNS AND WOUNDS > 2025 > 41(7): 698-703

Chen Yuxi, Luo Liang, Jiang Shiqing, et al. Research advances on the application of exosomal multi-omics analysis technology in warning and diagnosis of burn sepsis[J]. CHINESE JOURNAL OF BURNS AND WOUNDS, 2025, 41(7): 698-703. Doi: 10.3760/cma.j.cn501225-20250512-00222

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Research advances on the application of exosomal multi-omics analysis technology in warning and diagnosis of burn sepsis

doi: 10.3760/cma.j.cn501225-20250512-00222

Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China

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Key Program of National Natural Science Foundation of China 81530064

Shaanxi Provincial Key Research and Development Program of China 2023-ZDLSF-24

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Corresponding author: Hu Dahai, Email: hudahai@fmmu.edu.cn
Received Date: 2025-05-12

Abstract

Abstract

As one of the primary causes of death in burn patients, sepsis presents challenges in early warning and diagnosis, mainly due to its nonspecific clinical manifestations and the limitations of traditional biomarker detection efficiency. As an important carrier of intercellular information transfer, exosomes and their contents (RNAs, proteins, and metabolites) can reflect the pathophysiological status of the body, thus attracting significant attention in the field of disease diagnosis. This review aims to summarize the research advances of exosomal multi-omics (transcriptomics, proteomics, metabolomics, etc.) analysis technologies in the warning and diagnosis of burn sepsis, and explore their application potential in revealing disease mechanisms, screening specific early biomarkers, and integrating emerging bioinformatics technologies. The goal is to provide new strategies and directions for achieving the precision diagnosis and treatment of burn sepsis.
- Burns,
- Sepsis,
- Exosomes,
- Diagnosis,
- Systems biology,
- Biomarkers

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References

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Research advances on the application of exosomal multi-omics analysis technology in warning and diagnosis of burn sepsis

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Research advances on the application of exosomal multi-omics analysis technology in warning and diagnosis of burn sepsis

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