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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  >  > Accepted Manuscript
Yao Yongming,Ren Chao.Postburn infection and immune dysfunction: new translational horizons from the pathogenesis to precision medicine[J].Chin J Burns Wounds,2026,42(2):1-7.DOI: 10.3760/cma.j.cn501225-20251104-00457.
Citation: Yao Yongming,Ren Chao.Postburn infection and immune dysfunction: new translational horizons from the pathogenesis to precision medicine[J].Chin J Burns Wounds,2026,42(2):1-7.DOI: 10.3760/cma.j.cn501225-20251104-00457.
shu

Postburn infection and immune dysfunction: new translational horizons from the pathogenesis to precision medicine

doi: 10.3760/cma.j.cn501225-20251104-00457
  • 1.

    Medical Innovation Research Division and the Fourth Medical Center of the Chinese PLA General Hospital, Beijing 100853, China

  • 2.

    Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China

Funds:

National Key Research and Development Program of China 2022YFA1104600

Key Program of National Natural Science Foundation of China 82130062

More Information
  • Corresponding author: Yao Yongming, Email: c_ff@sina.com
  • Received Date: 2025-11-04
    Available Online: 2026-01-30
    Abstract
  • The "pathological vicious cycle" between skin barrier disruption and immune dysfunction renders infection a primary complication and main cause of death among burn patients. Burn-related sepsis patients account for more than 50% of all burn-associated deaths. Currently, the prevention and treatment of burn infections are confronted with multiple challenges: the superimposed effects of uncontrolled inflammatory response and immune disorder triggered by infection, the rapid progression from local wound to systemic damage, and the massive colonization of multidrug-resistant bacteria, which significantly increases the difficulty of antibacterial therapy. This paper conducted an in-depth analysis of the mechanisms underlying immune dysfunction after burn-related infections from phenotypic manifestations to intrinsic regulation. It systematically elaborated on the crucial roles and mechanisms in the pathogenesis of immune dysfunction, including immune evasion of multidrug-resistant bacteria, the failed balance of immune responses, intestinal flora, and novel subtypes of immune regulatory cells. This paper further reported the emerging technologies for infection assessment and immune monitoring among burn patients by integrating the latest advancements in intelligent wound detecting system and novel biomarkers. Focusing on innovative therapeutic strategies targeting postburn immune regulation and local microenvironment remodeling, it further analyzed the challenges in clinical translation and future development directions.

     

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