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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  >  > Accepted Manuscript
Zhu Yifu,Liu Ling,Song Baoqiang,et al.Clinical efficacy of fractional carbon dioxide laser combined with wet compresses using latanoprost ophthalmic solution in treating old self-injury scars with hypopigmentation[J].Chin J Burns Wounds,2026,42(4):1-10.DOI: 10.3760/cma.j.cn501225-20251230-00558.
Citation: Zhu Yifu,Liu Ling,Song Baoqiang,et al.Clinical efficacy of fractional carbon dioxide laser combined with wet compresses using latanoprost ophthalmic solution in treating old self-injury scars with hypopigmentation[J].Chin J Burns Wounds,2026,42(4):1-10.DOI: 10.3760/cma.j.cn501225-20251230-00558.
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Clinical efficacy of fractional carbon dioxide laser combined with wet compresses using latanoprost ophthalmic solution in treating old self-injury scars with hypopigmentation

doi: 10.3760/cma.j.cn501225-20251230-00558

  • Department of Plastic Surgery, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China

Funds:

General Program of National Natural Science Foundation of China 82372530

More Information
  • Corresponding author: Yang Qing, Email: anny0723hi@126.com
  • Received Date: 2025-12-30
    Available Online: 2026-03-31
    Abstract
  •   Objective  To explore the clinical efficacy of fractional carbon dioxide laser combined with wet compress using latanoprost ophthalmic solution in treating old self-injury scars with hypopigmentation.  Methods  This study was a retrospective cohort study. From January 1, 2018 to October 31, 2025, 136 patients with old self-injury scars accompanied by hypopigmentation who met the inclusion criteria were admitted to the Department of Plastic Surgery of the First Affiliated Hospital of Air Force Medical University. There were 41 males and 95 females, aged 13 to 25 years. Based on the treatment methods, the patients were categorized into laser-only group (79 patients, 602 scars) receiving fractional carbon dioxide laser treatment alone and combined treatment group (57 patients, 530 scars) receiving fractional carbon dioxide laser combined with wet compress using latanoprost ophthalmic solution. A total of four laser treatment was performed. Before the first treatment (hereinafter referred to as before surgery) and at 6 months after the last treatment (hereinafter referred to as 6 months after treatment), the modified observer scar assessment scale (OSAS) was used to independently score each scar in four dimensions: thickness, roughness, softness, and width; the degree of scar hypopigmentation was assessed based on the color scoring principles of the Vancouver scar scale, and the improvement rate of scar hypopigmentation was calculated. At 6 months after treatment, the satisfaction degree of patients or their family members with the scar treatment efficacy was recorded, and the satisfaction rate was calculated. The adverse reaction occurred during the treatment process was documented and the incidence of aclverse reaction was calculated.  Results  At 6 months after treatment, the scores for scar thickness, roughness, and softness in the modified OSAS in laser-only group and combined treatment group of patients (with t values of 35.381, 29.184, 37.659 and 36.158, 29.995, 38.596, respectively, P<0.05), as well as the scar width score in the modified OSAS in combined treatment group of patients (t=17.595, P<0.05) were significantly lower than those before treatment. The scar width score at 6 months after treatment in combined treatment group of patients was significantly lower than that in laser-only group (with mean difference of -0.48, 95% CI of -0.56 to -0.40, t=12.080, P<0.05). The difference in scar width score between 6 months after treatment and before treatment in combined treatment group and laser-only group of patients was -0.39±0.51 and 0.04±0.56, respectively, and there was statistically significant difference between the two groups (t=13.545, P<0.05). Multiple linear regression analysis showed that the treatment method was an independent influencing factor for the improvement of scar width in patients (β=-0.426, with 95% CI of -0.490 to -0.363, P<0.05). There was statistically significant difference in the degree of scar hypopigmentation between before treatment and at 6 months after treatment in combined treatment group of patients (Z=-3.594, P<0.05). The improvement rate of scar hypopigmentation in combined treatment group of patients at 6 months after treatment was 16.23% (86/530), which was significantly higher than 3.65% (22/602) in laser-only group (χ²=51.618, P<0.05). Binary multivariate logistic regression analysis showed that the treatment method was an independent influencing factor for the improvement of scar hypopigmentation in patients (OR=5.378, with 95% CI of 3.293 to 8.781, P<0.05). At 6 months after treatment, the satisfaction rate of patients or their family members in combined treatment group regarding the treatment efficacy of scar was significantly higher than that in laser-only group (χ²=6.458, P<0.05). The incidence of adverse reaction in combined treatment group of patients during treatment process was 17.54% (10/57), which was significantly higher than 3.80% (3/79) in laser-only group (P<0.05).  Conclusions  Fractional carbon dioxide laser combined with wet compress using latanoprost ophthalmic solution for the treatment of old self-injury scars with hypopigmentation demonstrates significant efficacy. It is significantly superior to fractional carbon dioxide laser alone regarding improvement of scar width and hypopigmentation grading and the satisfaction of patients.

     

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