Shen K,Wang XJ,Liu KT,et al.Effects of exosomes from human adipose-derived mesenchymal stem cells on inflammatory response of mouse RAW264.7 cells and wound healing of full-thickness skin defects in mice[J].Chin J Burns Wounds,2022,38(3):215-226.DOI: 10.3760/cma.j.cn501120-20201116-00477.
Citation: Wang YX,Chen JJ,Cen Y,et al.Research advances on exosomes derived from adipose-derived mesenchymal stem cells in promoting diabetic wound healing[J].Chin J Burns Wounds,2022,38(5):491-495.DOI: 10.3760/cma.j.cn501120-20210218-00057.

Research advances on exosomes derived from adipose-derived mesenchymal stem cells in promoting diabetic wound healing

doi: 10.3760/cma.j.cn501120-20210218-00057
Funds:

General Program of National Natural Science Foundation of China 81871574

Science and Technology Program of Sichuan Province of China 2020YFS0267

Scientific Research Project of Health Commission of Sichuan Province of China 19PJ097

More Information
  • Corresponding author: Zhang Zhenyu, Email: zzy137731@163.com
  • Received Date: 2021-02-18
  • Impaired healing of diabetic wounds is mainly attributed to its pathological mechanism, and refractory diabetic wounds bring heavy burdens to patients and society. Exosomes derived from stem cells possess the similar ability as stem cells in promoting tissue regeneration and more clinical advantages and are gradually playing  important roles in wound healing. In recent years, researches have shown that exosomes derived from adipose-derived mesenchymal stem cells (ADSC-EXOs) can promote the healing of diabetic wounds by participating in various processes of wound healing. This article reviews the pathological mechanism leading to impaired healing of diabetic wounds, the related mechanism and the application prospect of ADSC-EXOs in promoting diabetic wound healing.

     

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    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 3.1 %其他: 3.1 %其他: 0.2 %其他: 0.2 %China: 10.7 %China: 10.7 %Grove City: 0.1 %Grove City: 0.1 %Howard: 0.1 %Howard: 0.1 %Kao-sung: 0.0 %Kao-sung: 0.0 %Keelung: 0.1 %Keelung: 0.1 %San Lorenzo: 0.0 %San Lorenzo: 0.0 %Taoyuan District: 0.0 %Taoyuan District: 0.0 %[]: 0.1 %[]: 0.1 %三明: 0.5 %三明: 0.5 %三门峡: 0.1 %三门峡: 0.1 %上海: 1.4 %上海: 1.4 %东莞: 0.3 %东莞: 0.3 %丽水: 0.8 %丽水: 0.8 %京都府: 0.0 %京都府: 0.0 %佛山: 0.2 %佛山: 0.2 %信阳: 0.1 %信阳: 0.1 %克拉玛依: 0.1 %克拉玛依: 0.1 %六安: 0.4 %六安: 0.4 %兰州: 0.1 %兰州: 0.1 %包头: 0.1 %包头: 0.1 %北京: 2.1 %北京: 2.1 %北方邦: 0.0 %北方邦: 0.0 %十堰: 0.0 %十堰: 0.0 %南京: 1.0 %南京: 1.0 %南宁: 0.2 %南宁: 0.2 %南平: 0.7 %南平: 0.7 %南昌: 0.2 %南昌: 0.2 %南通: 0.2 %南通: 0.2 %南阳: 0.2 %南阳: 0.2 %厦门: 0.7 %厦门: 0.7 %台州: 1.0 %台州: 1.0 %合肥: 0.1 %合肥: 0.1 %吉林: 0.2 %吉林: 0.2 %呼和浩特: 0.3 %呼和浩特: 0.3 %咸阳: 1.7 %咸阳: 1.7 %哈尔滨: 0.1 %哈尔滨: 0.1 %哥伦布: 0.0 %哥伦布: 0.0 %唐山: 0.1 %唐山: 0.1 %嘉兴: 1.1 %嘉兴: 1.1 %大庆: 0.1 %大庆: 0.1 %大连: 1.1 %大连: 1.1 %天津: 0.2 %天津: 0.2 %太原: 0.0 %太原: 0.0 %孝感: 0.0 %孝感: 0.0 %宁德: 0.5 %宁德: 0.5 %宁波: 0.5 %宁波: 0.5 %安庆: 0.0 %安庆: 0.0 %安康: 0.3 %安康: 0.3 %宜春: 0.2 %宜春: 0.2 %宝鸡: 0.0 %宝鸡: 0.0 %宣城: 0.2 %宣城: 0.2 %宿迁: 1.4 %宿迁: 1.4 %巴音郭楞蒙古自治州: 0.1 %巴音郭楞蒙古自治州: 0.1 %常州: 0.1 %常州: 0.1 %常德: 0.4 %常德: 0.4 %平顶山: 0.1 %平顶山: 0.1 %广元: 0.1 %广元: 0.1 %广州: 1.0 %广州: 1.0 %廊坊: 0.1 %廊坊: 0.1 %张家口: 0.3 %张家口: 0.3 %徐州: 0.8 %徐州: 0.8 %德州: 0.1 %德州: 0.1 %德阳: 0.0 %德阳: 0.0 %怀化: 0.1 %怀化: 0.1 %成都: 0.4 %成都: 0.4 %扬州: 0.7 %扬州: 0.7 %抚州: 0.4 %抚州: 0.4 %拉贾斯坦邦: 0.2 %拉贾斯坦邦: 0.2 %新乡: 0.1 %新乡: 0.1 %新奥尔良: 0.0 %新奥尔良: 0.0 %无锡: 0.5 %无锡: 0.5 %日照: 0.1 %日照: 0.1 %昆明: 0.6 %昆明: 0.6 %朝阳: 0.4 %朝阳: 0.4 %杭州: 1.7 %杭州: 1.7 %枣庄: 0.0 %枣庄: 0.0 %梅州: 0.1 %梅州: 0.1 %榆林: 0.8 %榆林: 0.8 %武汉: 0.7 %武汉: 0.7 %汉中: 0.1 %汉中: 0.1 %汕头: 0.5 %汕头: 0.5 %池州: 0.7 %池州: 0.7 %沈阳: 1.0 %沈阳: 1.0 %河源: 0.1 %河源: 0.1 %泉州: 0.6 %泉州: 0.6 %泰州: 0.2 %泰州: 0.2 %泸州: 0.1 %泸州: 0.1 %洛阳: 0.1 %洛阳: 0.1 %济南: 0.2 %济南: 0.2 %海东: 0.0 %海东: 0.0 %海得拉巴: 0.1 %海得拉巴: 0.1 %海西: 0.1 %海西: 0.1 %淮北: 0.2 %淮北: 0.2 %淮南: 0.1 %淮南: 0.1 %淮安: 0.2 %淮安: 0.2 %深圳: 0.2 %深圳: 0.2 %温州: 0.4 %温州: 0.4 %渭南: 0.7 %渭南: 0.7 %湖州: 0.5 %湖州: 0.5 %湘潭: 0.0 %湘潭: 0.0 %湘西: 0.5 %湘西: 0.5 %湘西土家族苗族自治州: 0.0 %湘西土家族苗族自治州: 0.0 %湛江: 0.2 %湛江: 0.2 %滁州: 0.2 %滁州: 0.2 %漯河: 0.3 %漯河: 0.3 %漳州: 0.5 %漳州: 0.5 %潍坊: 0.0 %潍坊: 0.0 %珠海: 0.5 %珠海: 0.5 %盐城: 0.4 %盐城: 0.4 %盘锦: 0.0 %盘锦: 0.0 %石家庄: 0.6 %石家庄: 0.6 %福州: 0.8 %福州: 0.8 %秦皇岛: 0.3 %秦皇岛: 0.3 %绍兴: 0.8 %绍兴: 0.8 %绵阳: 0.3 %绵阳: 0.3 %自贡: 0.0 %自贡: 0.0 %舟山: 0.9 %舟山: 0.9 %芒廷维尤: 17.2 %芒廷维尤: 17.2 %芝加哥: 0.2 %芝加哥: 0.2 %苏州: 0.5 %苏州: 0.5 %茂名: 0.0 %茂名: 0.0 %荆州: 0.2 %荆州: 0.2 %荆门: 0.6 %荆门: 0.6 %莆田: 0.9 %莆田: 0.9 %营口: 0.4 %营口: 0.4 %葫芦岛: 0.5 %葫芦岛: 0.5 %蒙彼利埃: 0.0 %蒙彼利埃: 0.0 %蚌埠: 0.0 %蚌埠: 0.0 %衡水: 0.1 %衡水: 0.1 %衡阳: 0.1 %衡阳: 0.1 %衢州: 0.1 %衢州: 0.1 %襄阳: 0.1 %襄阳: 0.1 %西宁: 1.0 %西宁: 1.0 %西安: 2.6 %西安: 2.6 %贵阳: 0.0 %贵阳: 0.0 %辽阳: 0.5 %辽阳: 0.5 %运城: 0.0 %运城: 0.0 %连云港: 0.0 %连云港: 0.0 %通化: 0.0 %通化: 0.0 %遵义: 0.6 %遵义: 0.6 %邯郸: 0.1 %邯郸: 0.1 %邵阳: 0.1 %邵阳: 0.1 %郑州: 0.3 %郑州: 0.3 %郴州: 1.0 %郴州: 1.0 %重庆: 6.9 %重庆: 6.9 %金华: 0.9 %金华: 0.9 %金昌: 0.0 %金昌: 0.0 %铁岭: 1.1 %铁岭: 1.1 %铜陵: 0.3 %铜陵: 0.3 %银川: 0.0 %银川: 0.0 %锡林郭勒盟: 0.3 %锡林郭勒盟: 0.3 %锦州: 0.4 %锦州: 0.4 %长春: 0.3 %长春: 0.3 %长沙: 0.9 %长沙: 0.9 %随州: 0.3 %随州: 0.3 %雅安: 0.0 %雅安: 0.0 %青岛: 0.2 %青岛: 0.2 %鞍山: 2.8 %鞍山: 2.8 %韶关: 0.1 %韶关: 0.1 %鹰潭: 0.1 %鹰潭: 0.1 %黄冈: 0.6 %黄冈: 0.6 %黄南: 0.3 %黄南: 0.3 %黄山: 0.0 %黄山: 0.0 %黄石: 0.1 %黄石: 0.1 %其他其他ChinaGrove CityHowardKao-sungKeelungSan LorenzoTaoyuan District[]三明三门峡上海东莞丽水京都府佛山信阳克拉玛依六安兰州包头北京北方邦十堰南京南宁南平南昌南通南阳厦门台州合肥吉林呼和浩特咸阳哈尔滨哥伦布唐山嘉兴大庆大连天津太原孝感宁德宁波安庆安康宜春宝鸡宣城宿迁巴音郭楞蒙古自治州常州常德平顶山广元广州廊坊张家口徐州德州德阳怀化成都扬州抚州拉贾斯坦邦新乡新奥尔良无锡日照昆明朝阳杭州枣庄梅州榆林武汉汉中汕头池州沈阳河源泉州泰州泸州洛阳济南海东海得拉巴海西淮北淮南淮安深圳温州渭南湖州湘潭湘西湘西土家族苗族自治州湛江滁州漯河漳州潍坊珠海盐城盘锦石家庄福州秦皇岛绍兴绵阳自贡舟山芒廷维尤芝加哥苏州茂名荆州荆门莆田营口葫芦岛蒙彼利埃蚌埠衡水衡阳衢州襄阳西宁西安贵阳辽阳运城连云港通化遵义邯郸邵阳郑州郴州重庆金华金昌铁岭铜陵银川锡林郭勒盟锦州长春长沙随州雅安青岛鞍山韶关鹰潭黄冈黄南黄山黄石

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