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Volume 38 Issue 9
Sep.  2022
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2022  >  38(9): 887-892
Yuan HP,Ding YY,Zheng YX,et al.Research advances on the function of skin touch receptor Merkel cells[J].Chin J Burns Wounds,2022,38(9):887-892.DOI: 10.3760/cma.j.cn501120-20211209-00409.
Citation: Yuan HP,Ding YY,Zheng YX,et al.Research advances on the function of skin touch receptor Merkel cells[J].Chin J Burns Wounds,2022,38(9):887-892.DOI: 10.3760/cma.j.cn501120-20211209-00409.
shu

Research advances on the function of skin touch receptor Merkel cells

doi: 10.3760/cma.j.cn501120-20211209-00409
  • 1.

    Biomedical Research Center, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310020, China

  • 2.

    Centre for Drug Safety Evaluation and Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China

  • 3.

    Union College of Edinburgh University, Zhejiang University, Haining 314400, China

Funds:

General Program of National Natural Science Foundation of China 32070816

Natural Science Foundation of Zhejiang Province of China LQ22C070002

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    Abstract
  • The reconstruction of tactile function during the repair of skin damage caused by factors including burns is inseparable from the functional regeneration of tactile receptor Merkel cells. Merkel cells mainly exist in the basal layer of the epidermis and are closely connected with nerves to form Merkel cell-nerve complexes, which play an important role in biological organisms. A large number of studies have shown that Merkel cells conduct precise transmission of mechanical force stimuli through the mechanically gated ion channels PIEZO2, and perform the function of tactile receptors. In this paper, we discussed the characteristics of Merkel cells and analyzed the different subgroups that may possibly exist in this type of cells and their functions, at the same time, we investigated the animal model research of touch-related diseases and the clinical diseases related to touch, revealing the importance of Merkel cell function research.

     

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    • References(46)
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    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 6.7 %其他: 6.7 %其他: 0.9 %其他: 0.9 %Central District: 0.1 %Central District: 0.1 %Saitama: 0.1 %Saitama: 0.1 %上海: 4.7 %上海: 4.7 %东莞: 1.0 %东莞: 1.0 %中山: 0.1 %中山: 0.1 %丽水: 0.1 %丽水: 0.1 %仰光: 0.1 %仰光: 0.1 %佛山: 0.3 %佛山: 0.3 %保定: 0.3 %保定: 0.3 %北京: 4.9 %北京: 4.9 %南京: 1.4 %南京: 1.4 %南宁: 0.7 %南宁: 0.7 %台州: 0.3 %台州: 0.3 %合肥: 0.1 %合肥: 0.1 %吉林: 0.1 %吉林: 0.1 %吉隆坡: 0.1 %吉隆坡: 0.1 %天津: 1.0 %天津: 1.0 %太原: 0.1 %太原: 0.1 %宁波: 0.3 %宁波: 0.3 %安康: 0.1 %安康: 0.1 %宜春: 0.6 %宜春: 0.6 %山景城: 0.1 %山景城: 0.1 %广州: 2.0 %广州: 2.0 %张家口: 3.3 %张家口: 3.3 %徐州: 0.1 %徐州: 0.1 %成都: 1.1 %成都: 1.1 %扬州: 0.3 %扬州: 0.3 %拉斯维加斯: 0.1 %拉斯维加斯: 0.1 %拉贾斯坦邦: 0.4 %拉贾斯坦邦: 0.4 %昆明: 0.6 %昆明: 0.6 %朝阳: 0.1 %朝阳: 0.1 %杭州: 6.2 %杭州: 6.2 %武汉: 0.7 %武汉: 0.7 %水原: 0.1 %水原: 0.1 %汕头: 0.1 %汕头: 0.1 %江门: 0.1 %江门: 0.1 %沈阳: 0.3 %沈阳: 0.3 %洛杉矶: 0.1 %洛杉矶: 0.1 %洛阳: 0.9 %洛阳: 0.9 %济南: 0.4 %济南: 0.4 %海得拉巴: 0.4 %海得拉巴: 0.4 %淄博: 0.1 %淄博: 0.1 %淮南: 0.1 %淮南: 0.1 %深圳: 1.9 %深圳: 1.9 %温州: 0.3 %温州: 0.3 %湛江: 0.1 %湛江: 0.1 %漯河: 0.7 %漯河: 0.7 %潍坊: 0.1 %潍坊: 0.1 %烟台: 0.1 %烟台: 0.1 %爱丁堡: 0.1 %爱丁堡: 0.1 %珠海: 0.3 %珠海: 0.3 %石家庄: 0.4 %石家庄: 0.4 %福州: 0.4 %福州: 0.4 %绵阳: 0.4 %绵阳: 0.4 %舟山: 0.3 %舟山: 0.3 %芒廷维尤: 31.2 %芒廷维尤: 31.2 %芝加哥: 0.6 %芝加哥: 0.6 %苏州: 1.9 %苏州: 1.9 %苏黎世: 0.6 %苏黎世: 0.6 %莫斯科: 0.4 %莫斯科: 0.4 %菏泽: 0.1 %菏泽: 0.1 %衡水: 1.4 %衡水: 1.4 %衢州: 0.3 %衢州: 0.3 %西宁: 4.2 %西宁: 4.2 %西安: 0.7 %西安: 0.7 %西雅图: 0.1 %西雅图: 0.1 %贵阳: 0.3 %贵阳: 0.3 %运城: 0.1 %运城: 0.1 %遵义: 0.3 %遵义: 0.3 %郑州: 0.4 %郑州: 0.4 %重庆: 4.6 %重庆: 4.6 %金华: 0.1 %金华: 0.1 %锦州: 0.4 %锦州: 0.4 %长春: 0.6 %长春: 0.6 %长沙: 2.6 %长沙: 2.6 %长治: 0.1 %长治: 0.1 %青岛: 0.6 %青岛: 0.6 %香港: 0.3 %香港: 0.3 %黄冈: 0.1 %黄冈: 0.1 %其他其他Central DistrictSaitama上海东莞中山丽水仰光佛山保定北京南京南宁台州合肥吉林吉隆坡天津太原宁波安康宜春山景城广州张家口徐州成都扬州拉斯维加斯拉贾斯坦邦昆明朝阳杭州武汉水原汕头江门沈阳洛杉矶洛阳济南海得拉巴淄博淮南深圳温州湛江漯河潍坊烟台爱丁堡珠海石家庄福州绵阳舟山芒廷维尤芝加哥苏州苏黎世莫斯科菏泽衡水衢州西宁西安西雅图贵阳运城遵义郑州重庆金华锦州长春长沙长治青岛香港黄冈

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      沈阳化工大学材料科学与工程学院 沈阳 110142

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