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Volume 39 Issue 2
Feb.  2023
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Article Navigation >  CHINESE JOURNAL OF BURNS AND WOUNDS  > 2023  >  39(2): 175-183
You AJ,Li WJ,Zhou JL,et al.Meta-analysis of the effects of xenogeneic acellular dermal matrix dressings in the treatment of wounds in burn patients[J].Chin J Burns Wounds,2023,39(2):175-183.DOI: 10.3760/cma.j.cn501120-20220106-00008.
Citation: You AJ,Li WJ,Zhou JL,et al.Meta-analysis of the effects of xenogeneic acellular dermal matrix dressings in the treatment of wounds in burn patients[J].Chin J Burns Wounds,2023,39(2):175-183.DOI: 10.3760/cma.j.cn501120-20220106-00008.
shu

Meta-analysis of the effects of xenogeneic acellular dermal matrix dressings in the treatment of wounds in burn patients

doi: 10.3760/cma.j.cn501120-20220106-00008

  • School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou 510006, China

Funds:

Guangdong Provincial Education Department University Special Innovation Project 2020KTSCX025

More Information
  • Corresponding author: Li Chun, Email: 376962485@qq.com
  • Received Date: 2022-01-06
    Abstract
  •   Objective  To evaluate the efficacy and safety of xenogeneic acellular dermal matrix (ADM) dressings for the treatment of wounds in burn patients.  Methods  The meta-analysis method was adopted. Databases including Chinese Journal Full-text Database, Wanfang Database, VIP Database, and Chinese Biomedical Database were retrieved with the search terms in Chinese version of "异种脱细胞真皮基质, 敷料, 烧伤创面, 烧伤" and PubMed, Embase, Web of Science, and Cochrane Library were retrieved with the search terms in English version of "xenogeneic acellular dermal matrix, dressing, burn wound, burn" to obtain the publicly published randomized controlled trials on the efficacy of xenogeneic ADM dressings for the treatment of wounds in burn patients from the establishment of each database to December 2021. The outcome indexes included wound healing time, ratio of scar hyperplasia, Vancouver scar scale (VSS) score, ratio of complications, ratio of skin grafting, and ratio of bacteria detection. Rev Man 5.3 and Stata 14.0 statistical softwares were used to conduct a meta-analysis of eligible studies.  Results  A total of 1 596 burn patients from 16 studies were included, including 835 patients in experimental group who received xenogeneic ADM dressings therapy and 761 patients in control group who received other methods therapy. The bias risk of all the 16 included studies was uncertain. Compared with those in control group, patients in experimental group had significantly shorter wound healing time, lower VSS scores (with standardized mean differences of -2.50 and -3.10, 95% confidence intervals of -3.02--1.98 and -4.87--1.34, respectively, P values both <0.05), and lower ratios of scar hyperplasia, complications, skin grafting, and bacteria detection (with relative risks of 0.58, 0.23, 0.32, and 0.27, 95% confidence intervals of 0.43-0.80, 0.14-0.37, 0.15-0.67, and 0.11-0.69, respectively, P<0.05). Subgroup analysis showed that the difference of intervention measures in control group might be the source of heterogeneity in wound healing time. There was no publication bias in ratio of scar hyperplasia (P≥0.05), while there was publication bias in wound healing time, VSS score, and ratio of complications (P<0.05).  Conclusions  Xenogeneic ADM dressings can shorten the wound healing time of burn patients, reduce the VSS score and the ratios of scar hyperplasia, complications, skin grafting, and bacteria detection.

     

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    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 7.3 %其他: 7.3 %其他: 0.4 %其他: 0.4 %Central District: 0.1 %Central District: 0.1 %China: 0.3 %China: 0.3 %North Point: 0.1 %North Point: 0.1 %Seattle: 0.1 %Seattle: 0.1 %[]: 0.1 %[]: 0.1 %上海: 3.6 %上海: 3.6 %上达比: 0.1 %上达比: 0.1 %东莞: 0.6 %东莞: 0.6 %丽水: 0.3 %丽水: 0.3 %佛山: 0.3 %佛山: 0.3 %六安: 0.1 %六安: 0.1 %兰州: 0.3 %兰州: 0.3 %内江: 0.4 %内江: 0.4 %北京: 4.6 %北京: 4.6 %北海: 0.1 %北海: 0.1 %南京: 1.3 %南京: 1.3 %南宁: 0.3 %南宁: 0.3 %南昌: 0.4 %南昌: 0.4 %南通: 0.3 %南通: 0.3 %台州: 0.3 %台州: 0.3 %哈尔滨: 0.1 %哈尔滨: 0.1 %唐山: 0.9 %唐山: 0.9 %嘉兴: 0.1 %嘉兴: 0.1 %天水: 0.4 %天水: 0.4 %天津: 1.1 %天津: 1.1 %太原: 0.3 %太原: 0.3 %奥马哈: 0.3 %奥马哈: 0.3 %宁波: 0.6 %宁波: 0.6 %安康: 0.3 %安康: 0.3 %宣城: 0.6 %宣城: 0.6 %宿州: 0.1 %宿州: 0.1 %山景城: 0.1 %山景城: 0.1 %常州: 0.4 %常州: 0.4 %平顶山: 0.1 %平顶山: 0.1 %广州: 1.4 %广州: 1.4 %廊坊: 0.3 %廊坊: 0.3 %张家口: 1.7 %张家口: 1.7 %徐州: 0.1 %徐州: 0.1 %成都: 1.7 %成都: 1.7 %扬州: 0.3 %扬州: 0.3 %拉贾斯坦邦: 0.4 %拉贾斯坦邦: 0.4 %无锡: 0.3 %无锡: 0.3 %昆明: 1.1 %昆明: 1.1 %朝阳: 0.1 %朝阳: 0.1 %杭州: 0.7 %杭州: 0.7 %格兰特县: 0.1 %格兰特县: 0.1 %桂林: 0.1 %桂林: 0.1 %梧州: 0.7 %梧州: 0.7 %武汉: 0.7 %武汉: 0.7 %汕头: 0.3 %汕头: 0.3 %江门: 0.1 %江门: 0.1 %沈阳: 0.9 %沈阳: 0.9 %洛阳: 0.6 %洛阳: 0.6 %济南: 0.4 %济南: 0.4 %海口: 0.1 %海口: 0.1 %海得拉巴: 0.4 %海得拉巴: 0.4 %淮安: 0.3 %淮安: 0.3 %深圳: 1.7 %深圳: 1.7 %温州: 0.3 %温州: 0.3 %渭南: 0.4 %渭南: 0.4 %漯河: 0.3 %漯河: 0.3 %烟台: 0.1 %烟台: 0.1 %石家庄: 0.3 %石家庄: 0.3 %福州: 0.3 %福州: 0.3 %秦皇岛: 0.3 %秦皇岛: 0.3 %芒廷维尤: 39.1 %芒廷维尤: 39.1 %芝加哥: 0.9 %芝加哥: 0.9 %苏州: 0.1 %苏州: 0.1 %菏泽市牡丹: 0.1 %菏泽市牡丹: 0.1 %衡阳: 0.4 %衡阳: 0.4 %西宁: 3.4 %西宁: 3.4 %西安: 0.6 %西安: 0.6 %贵阳: 0.7 %贵阳: 0.7 %赣州: 0.4 %赣州: 0.4 %运城: 0.1 %运城: 0.1 %连云港: 0.1 %连云港: 0.1 %郑州: 0.1 %郑州: 0.1 %重庆: 4.3 %重庆: 4.3 %镇江: 0.3 %镇江: 0.3 %长沙: 3.1 %长沙: 3.1 %阜阳: 0.1 %阜阳: 0.1 %防城港: 0.1 %防城港: 0.1 %阳泉: 0.3 %阳泉: 0.3 %青岛: 1.0 %青岛: 1.0 %香港: 0.3 %香港: 0.3 %驻马店: 0.1 %驻马店: 0.1 %其他其他Central DistrictChinaNorth PointSeattle[]上海上达比东莞丽水佛山六安兰州内江北京北海南京南宁南昌南通台州哈尔滨唐山嘉兴天水天津太原奥马哈宁波安康宣城宿州山景城常州平顶山广州廊坊张家口徐州成都扬州拉贾斯坦邦无锡昆明朝阳杭州格兰特县桂林梧州武汉汕头江门沈阳洛阳济南海口海得拉巴淮安深圳温州渭南漯河烟台石家庄福州秦皇岛芒廷维尤芝加哥苏州菏泽市牡丹衡阳西宁西安贵阳赣州运城连云港郑州重庆镇江长沙阜阳防城港阳泉青岛香港驻马店

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      沈阳化工大学材料科学与工程学院 沈阳 110142

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