2022 Vol. 38, No. 10

Expert Forum
In situ monitoring and regulation of local reactive oxygen species levels to promote wound repair
Luo Gaoxing, Deng Jun
2022, 38(10): 899-904. doi: 10.3760/cma.j.cn501225-20220720-00299
Abstract:
Local oxidative stress and inflammatory response are the essential procedures in wound repair, which determine the progress, prognosis, and quality of wound repair. Reactive oxygen species is one of the important indexes reflecting oxidative stress and inflammatory response of body, which is conside...
Original Articles·Application of Biological Materials in Wound Repair
Application of three-dimensional bioprinting ink containing platelet-rich plasma derived from human umbilical cord blood in the treatment of full-thickness skin defects in nude mice
Song Wei, Li Zhao, Zhu Shijun, Zhang Chao, Yao Bin, Kong Yi, Liang Liting, Enhejirigala, Fu Xiaobing, Huang Sha
2022, 38(10): 905-913. doi: 10.3760/cma.j.cn501225-20220618-00243
Abstract:
Objective To investigate the printability and cytocompatibility of sodium alginate-gelatin (AG) bioink containing platelet-rich plasma derived from human umbilical cord blood (HUCB-PRP), named HUCB-PRP-AG bioink, and the effect of the three-dimensionally printed tissue with the bioink on full-thickn...
Effect of P311 microspheres-loaded thermosensitive chitosan hydrogel on the wound healing of full-thickness skin defects in rats
Zhang Qingrong, Chen Changyou, Xu Na, Lyu Dalun, Jia Jiezhi, Li Wenhong, Luo Gaoxing, Yu Yunlong, Zhang Yi
2022, 38(10): 914-922. doi: 10.3760/cma.j.cn501225-20220414-00135
Abstract:
Objective To explore the effect of P311 microspheres-loaded thermosensitive chitosan hydrogel on the wound healing of full-thickness skin defects in rats. Methods The method of experimental study was adopted. The polyvinyl alcohol/sodium alginate microspheres (simple microspheres), P311 microspheres...
Effects and mechanism of water-soluble chitosan hydrogel on infected full-thickness skin defect wounds in diabetic mice
Zhu Meng, Chen Yuzhou, Ou Jinzhao, Li Zhao, Huang Sha, Hu Xiaohua, Ju Xiaoyan, Tian Ye, Niu Zhongwei
2022, 38(10): 923-931. doi: 10.3760/cma.j.cn501225-20220507-00175
Abstract:
Objective To explore the effects and mechanism of water-soluble chitosan hydrogel on infected full-thickness skin defect wounds in diabetic mice. Methods The experimental research method was adopted. The control hydrogel composed of polyvinyl alcohol and gelatin, and the water-soluble chitosan hydro...
Original Articles
Clinical effects of lateral supramalleolar perforator island flaps with low rotation points in repairing foot skin and soft tissue defect wounds
Chen Liming, Wang Gang, Liu Yi
2022, 38(10): 932-936. doi: 10.3760/cma.j.cn501120-20210630-00231
Abstract:
Objective To investigate the clinical effects of lateral supramalleolar perforator island flaps with low rotation points in repairing foot skin and soft tissue defect wounds. Methods The retrospective observational study was conducted. From October 2017 to August 2020, 14 patients (6 males and 8 fem...
Comparative study of the effects between second toe tibial dorsal artery flap and second toe tibial plantar proper artery flap in repairing finger skin and soft tissue defects
Li Jin, Wu Haibo, Jin Guangzhe, Zhu Congkun, Wang Kai, Wang Qiang, Ju Jihui, Hou Ruixing
2022, 38(10): 937-943. doi: 10.3760/cma.j.cn501120-20210909-00310
Abstract:
Objective To compare the effects between second toe tibial dorsal artery flap (2-TDAF) and second toe tibial plantar proper artery flap (2-TPPAF) in repairing finger skin and soft tissue defects. Methods A retrospective cohort study was conducted. From January 2019 to June 2020, 27 patients with ski...
Screening, functional analysis and clinical validation of differentially expressed genes in diabetic foot ulcers
Wang Peng, Chen Zhaohong, Jiang Liyuan, Zhou Xiaoqian, Jia Chiyu, Xiao Hou'an
2022, 38(10): 944-951. doi: 10.3760/cma.j.cn501225-20220731-00328
Abstract:
Objective To screen the differentially expressed genes (DEGs) in diabetic foot ulcers (DFUs), and to perform functional analysis and clinical validation of them, intending to lay a theoretical foundation for epigenetic therapy of chronic refractory wounds. Methods An observational study was conducte...
Original Article·Nursing Column
Clinical application effect of sequential nursing on the management of new skin on face and neck after deep burns
Fu Qingqing, Li Maojun, Huang Ling, Tan Jianglin, Zhou Yaqin, Li Ning
2022, 38(10): 952-958. doi: 10.3760/cma.j.cn501120-20210323-00101
Abstract:
Objective To explore the clinical application effect of sequential nursing on the management of new skin on face and neck after deep burns. Methods The retrospective case-control research approach was used. From January to December 2019, 109 patients who met the inclusion criteria were admitted to t...
Wound Repair
Clinical effects of proximal ulnar artery perforator flap combined with iliac bone graft in the reconstruction of subtotal thumb or finger defects
Zhang Yujun, Ju Jihui, Zhao Qiang, Wang Benyuan, Cheng Heyun, Wang Guiyang, Hou Ruixing
2022, 38(10): 959-963. doi: 10.3760/cma.j.cn501120-20210707-00238
Abstract:
Objective To explore the clinical effects of proximal ulnar artery perforator flap combined with iliac bone graft in the reconstruction of subtotal thumb or finger defects. Methods A retrospective observational study was conducted. From August 2016 to August 2019, 7 patients with thumb or finger def...
Case Report and Literature Review
Transplantation of bilateral superficial inferior epigastric artery perforator flap for breast reconstruction in a patient with unilateral breast cancer
Song Dajiang, Li Zan, Zhou Xiao, Zhang Yixin, Zhou Bo, Lyu Chunliu, Tang Yuanyuan, Yi Liang, Luo Zhenhua
2022, 38(10): 964-967. doi: 10.3760/cma.j.cn501225-20220306-00047
Abstract:
On May 14, 2020, a 37 year old female patient with unilateral breast cancer was admitted to Hunan Cancer Hospital. She underwent modified radical mastectomy for right breast cancer and free transplantation of bilateral superficial inferior epigastric artery perforator flap (weighed 305 g) for breast...
Reviews·Application of Biological Materials in Wound Repair
Research advances on the construction of artificial dermal scaffolds based on biomaterials
Chen Jiqiu, Zhu Shihui
2022, 38(10): 968-972. doi: 10.3760/cma.j.cn501225-20220606-00221
Abstract:
In the field of wound repair, scarless healing and complete reconstruction of skin function are major challenges in clinical and basic research. At present, a variety of artificial dermal scaffolds have been used in the clinical repair of wounds to overcome the problems such as skin structural disor...
Research advances on the application of silk fibroin biomaterials in wound repair
Ding Zhaozhao, Lyu Qiang
2022, 38(10): 973-977. doi: 10.3760/cma.j.cn501225-20220602-00212
Abstract:
Silk fibroin, a natural fibrin, is a suitable matrix biomaterial for wound repair due to its unique properties such as good biocompatibility, tunable biodegradation and mechanical properties, low host inflammatory response, low cost, ease of fabrication, etc. Silk fibroin can be used alone or in com...
Research advances on the application of natural and recombinant collagen in wound repair
Liu Xiaogang, Chen Lei, Li Haihang, Hu Yanke, Xiong Yahui, Huang Wei, Su Shasha, Qi Shaohai
2022, 38(10): 978-982. doi: 10.3760/cma.j.cn501120-20211123-00394
Abstract:
Collagen is a macromolecular protein constituting the extracellular matrix of animal connective tissue, which has been widely used and developed in fields of biomedicine, tissue engineering, food, and cosmetics. Due to its advantages such as abundant sources and good biocompatibility, low immunogeni...
Reviews
Research advances on the construction of an ideal scar model in vitro based on innovative tissue engineering technology
Zhu Dongzhen, Yao Bin, Yan Ziqiang, Huang Sha, Fu Xiaobing
2022, 38(10): 983-988. doi: 10.3760/cma.j.cn501120-20210723-00257
Abstract:
The scar brings a huge economic burden and creates a serious psychological shadow for patients. Although the current methods for scar treatment tend to be diversified, the treatment method that can truly achieve the goal of "perfect healing" or "scarless healing" after human skin injury is quite sca...
Research advances on the effects of RNA N6-methyladenosine modification in the relevant pathophysiological processes of wound repair
Liu Xiaoxiao, Liu Dewu
2022, 38(10): 989-993. doi: 10.3760/cma.j.cn501120-20210804-00267
Abstract:
N6-methyladenosine (m6A) exists widely in eukaryotes as a post-transcriptional modification. This modification is dynamically and reversibly regulated by methyltransferases and demethylases, and is involved in regulating biological effects through m6A binding proteins. Recent studies have elucidated...
Research advances on burn blister fluid
Dong Hongfei, Huang Xi, You Shuang, Li Xianhui
2022, 38(10): 994-998. doi: 10.3760/cma.j.cn501120-20211109-00380
Abstract:
Burns often cause the damaged tissue to produce a large amount of exudate and the formation of blisters on the wound. The burn blister fluid contains a large number of molecules related to wound healing, which can reflect the state of local tissue microenvironment of the burn wound. Analyzing releva...