2022 Vol. 38, No. 11

Expert Forum
To strengthen the basic and translational research of mesenchymal stem cell-based therapy for refractory wounds
Shi Chunmeng
2022, 38(11): 999-1003. doi: 10.3760/cma.j.cn501225-20220913-00405
Abstract:
In recent years, the application of cell-based therapy in the field of refractory wound repair has shown broad prospects, among which the mesenchymal stem cell is the most concerned and widely studied cell type. Despite the rapid development of clinical translational research, the therapeutic effect...
Original Articles · Wound Repair and Cell Therapy
Effects of exosomes from hepatocyte growth factor-modified human adipose mesenchymal stem cells on full-thickness skin defect in diabetic mice
Cao Tao, Xiao Dan, Ji Peng, Zhang Zhi, Cai Weixia, Han Chao, Li Wen, Tao Ke
2022, 38(11): 1004-1013. doi: 10.3760/cma.j.cn501225-20220731-00330
Abstract:
Objective To investigate the effects and mechanism of exosomes from hepatocyte growth factor (HGF)-modified human adipose mesenchymal stem cells (ADSCs) on full-thickness skin defect wounds in diabetic mice. Methods The experimental study method was adopted. Discarded adipose tissue of 3 healthy fem...
Effect of P62 on the migration and motility of human epidermal cell line HaCaT in high glucose microenvironment and its mechanism
Zhang Yuping, Zhang Qiong, Deng Fang, Chen Bing, Zhang Junhui, Hu Jiongyu
2022, 38(11): 1014-1022. doi: 10.3760/cma.j.cn501225-20220630-00272
Abstract:
Objective To investigate the effect of P62 on the migration and motility of human epidermal cell line HaCaT in high glucose microenvironment and its possible molecular mechanism, so as to explore the mechanism of refractory diabetic foot wound healing. Methods The method of experimental research was...
Effects and mechanism of human umbilical vein endothelial cells-derived exosomes on wound healing in diabetic rabbits
Yi Jiarong, Li Zenan, Xie Huiqing, Chen Shuyue, Jiang Bimei, Qian Li, Xu Lixin, Li Haihong, Lei Shaorong, Chen Zhizhao, Zhou Jianda
2022, 38(11): 1023-1033. doi: 10.3760/cma.j.cn501225-20220622-00254
Abstract:
Objective The investigate the effects and mechanism of exosomes derived from human umbilical vein endothelial cells (HUVECs) on wound healing in diabetes rabbits. Methods The experimental research methods were used. The primary vascular endothelial cells (VECs) and human skin fibroblasts (HSFs) were...
Original Articles
Application and clinical efficacy of ultrasound debridement method in residual burn wounds
He Zeliang, Li Jin, Sui Zhenyang, Zhang Julei, An Liang'en, Liu Lingling, Zhang Chengliang, Yao Yuanyuan, Qiu Shulin, Li Xiaodong
2022, 38(11): 1034-1039. doi: 10.3760/cma.j.cn501120-20211123-00396
Abstract:
Objective To investigate the application and clinical efficacy of ultrasound debridement method in residual burn wounds. Methods A retrospective cohort study was conducted. From August 2017 to August 2021, 64 patients with residual burn wounds who met the inclusion criteria were admitted to the 980t...
The regularity of sensory recovery after wound repair on the wrist and back of hand with anterolateral femoral flap without nerve anastomosis
Zhou Yao, Ju Jihui, Tang Linfeng, Wang Kai, Zhou Rong, Guo Liping, Yang Liang
2022, 38(11): 1040-1046. doi: 10.3760/cma.j.cn501120-20211014-00350
Abstract:
Objective To investigate the regularity of sensory recovery after repairing the wounds on the wrist and back of hand with anterolateral femoral flap without nerve anastomosis. Methods A cross-sectional study was conducted. From January 2018 to December 2020, patients who underwent free anterolater...
Effects of Krüppel-like factor 4 on inflammatory response and organ injury in septic mice
Wang Yunwei, Liu Yang, Cao Peng, Zhang Qingyi, Chen Yang, Li Shaohui, Guan Hao
2022, 38(11): 1047-1056. doi: 10.3760/cma.j.cn501225-20220111-00005
Abstract:
Objective To explore the expression characteristics and role of Krüppel-like factor 4 (KLF4) in macrophage inflammatory response and its effects on inflammatory response and organ injury in septic mice, so as to lay a theoretical foundation for targeted treatment of burns and trauma sepsis. Methods ...
Effect of deep dermal tissue dislocation injury on skin fibrosis in pig
Yu Xiaoping, Liu Yingkai, Ma Xian, Tang Jiajun, Niu Yiwen, Zhou Junli, Lu Shuliang
2022, 38(11): 1057-1065. doi: 10.3760/cma.j.cn501120-20210831-00301
Abstract:
Objective To explore the effect of deep dermal tissue dislocation injury on skin fibrosis in pig, in order to provide some theoretical basis for burn scar treatment. Methods The experimental research method was applied. Six 2-month-old female Duroc pigs were taken. Fifteen operative areas on the rig...
Regulatory effects of bio-intensity electric field on microtubule acetylation in human epidermal cell line HaCaT
Wu Yating, Zhang Ze, Ji Ran, Zhang Shuhao, Wang Wenping, Wu Chao, Zhang Jiaping, Jiang Xupin, Zhang Hengshu
2022, 38(11): 1066-1072. doi: 10.3760/cma.j.cn501120-20211105-00377
Abstract:
Objective To investigate the regulatory effects of bio-intensity electric field on directional migration and microtubule acetylation in human epidermal cell line HaCaT, aiming to provide molecular theoretical basis for the clinical treatment of wound repair. Methods The experimental research methods...
Original Article·Nursing Column
A cross-sectional survey and analysis of influencing factors of humanistic of the current status of humanistic care ability of burn specialist nurses
Jiang Qiqi, Zhang Yin, Qiao Liang, Zha Qinghua, Xie Lin, Luo Zhizhen
2022, 38(11): 1073-1078. doi: 10.3760/cma.j.cn501120-20210318-00092
Abstract:
Objective To investigate the current status of humanistic care ability of burn specialist nurses and to analyze the influencing factors. Methods A single-center cross-sectional research method was conducted. From May to August 2020, 63 burn specialist nurses who met the inclusion criteria in Ruijin ...
Meta-analysis of the interventional effects of music therapy on pain and anxiety of burn patients in wound dressing change
Li Ye, Liu Fangli, Yuan Ju, Li Jing, Liu Ziwei, Guan Ningxiao
2022, 38(11): 1079-1084. doi: 10.3760/cma.j.cn501120-20210716-00252
Abstract:
Objective To evaluate the interventional effects of music therapy on pain and anxiety of burn patients in wound dressing change. Methods The meta-analysis method was adopted. Databases including China National Knowledge Internet, Wanfang Database, and VIP database were retrieved with the search term...
Reviews
Research advances on the mechanism of refractory healing of diabetic foot ulcer
Wang Ning, Ju Shang
2022, 38(11): 1085-1089. doi: 10.3760/cma.j.cn501225-20220227-00038
Abstract:
The number of patients with diabetic foot ulcer (DFU) has increased progressively year by year. Refractory DFU has brought great burden to the country and individuals. How to accelerate the healing of DFU has become the main emphasis of research. However currently, the mechanism of its refractory he...
Progress in research and development of soft tissue three-dimensional bioprinting and its supporting equipment
Hu Yanke, Chen Shuying, Zhou Fei, Xiong Yahui, Chen Lei, Qi Shaohai
2022, 38(11): 1090-1095. doi: 10.3760/cma.j.cn501120-20210922-00327
Abstract:
As a cutting-edge technology of tissue engineering, three-dimensional bioprinting can accurately fabricate biomimetic tissue, which has made great progress in the field of hard tissue printing such as bones and teeth. Meanwhile, the research on soft tissue bioprinting is also developing rapidly. Thi...
Research progress of the application of methacrylic anhydride gelatin hydrogel in wound repair
Ding Neng, Fu Xinxin, Wu Haimei, Zhu Lie
2022, 38(11): 1096-1100. doi: 10.3760/cma.j.cn501225-20220308-00056
Abstract:
Wound repair is a common clinical problem, which seriously affects the quality of life of patients and also brings a heavy burden to the society. Hydrogel-based multifunctional dressing has shown strong potential in the treatment of acute and chronic wounds. In addition to its good histocompatibilit...